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Chinese proprietary medicine

A technology of Shuanghuanglian and cyclodextrin, which is applied in the direction of non-active ingredients of polymer compounds, drug combinations, antibacterial drugs, etc., can solve the problems of low product quality and stability of drug efficacy, complex composition of preparations, and difficult quality control, etc. problem, to achieve the effect of good chemical composition reproducibility, stable sample quality and controllable quality

Inactive Publication Date: 2008-10-22
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Shuanghuanglian preparations use the traditional method of water extraction and alcohol precipitation to extract active ingredients. The composition of the prepared preparations is complex and the content is low, resulting in a large dosage of the preparations, difficult to control the quality, and low product quality and efficacy stability.
[0003] There are no reports on the research on the cyclodextrin action of Shuanghuanglian compound, the preparation of inclusion complexes, and the experimental research on the anti-endotoxin-lethal mice

Method used

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  • Chinese proprietary medicine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1, inclusion: the traditional Chinese medicine Shuanghuanglian was washed, dried and pulverized according to the usual method to obtain a medicinal powder. Mix β-cyclodextrin with 20 times the amount of pure water to form a suspension or solution, add 1 / 3 of the amount of medicinal powder relative to the mass ratio of β-cyclodextrin, mix well, soak overnight, and heat at 60°C Stir for 24 hours, filter hot, cool the filtrate, extract the dregs with β-cyclodextrin and heat at 60°C once, filter, combine the filtrates, cool, filter, wash the solids twice with water, and dry at 60°C to obtain a light color Solid matter (inclusion composition).

[0060] Deinclusion: Blend the clathrate with a small amount of water to form a paste, heat at 70°C and gradually add 15 times the amount of ethanol, then reflux for 2 hours, cool and filter, add 10 times the amount of ethanol to the residual solid to extract once, combine the filtrate, The solvent was evaporated to obtain a ...

Embodiment 2

[0062] Example 2, traditional Chinese medicine Shuanghuanglian medicinal material powder is prepared dark extract (crude extract) by the usual ethanol extraction method. Mix 1 part of the crude extract with 10 parts of β-cyclodextrin and 30 parts of pure water, stir at 60°C for 8 hours, cool, filter, wash the solid with water twice, and dry at 60°C to obtain a light-colored solid (inclusion composition).

[0063] The light-colored inclusion composition is decomplexed and refined to obtain a yellow solid composition in a non-inclusion state.

Embodiment 3

[0064] Example 3, the traditional Chinese medicine Shuanghuanglian medicinal material powder is extracted by the usual water extraction and alcohol precipitation method to obtain a crude extract. Mix 1 part of the crude extract with 10 parts of β-cyclodextrin and 30 parts of pure water, stir at 60°C for 8 hours, cool, filter, wash the solid with water twice, and dry at 60°C to obtain a light-colored solid (combination).

[0065] The light-colored inclusion composition is decomplexed and refined to obtain a yellow solid composition in a non-inclusion state.

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Abstract

Disclosed is a cyclodextrin molecular composition of Shuanghuanglian, a traditional Chinese medicinal herb, which comprises Shuanghuanglian and cyclodextrin, wherein the Shuanghuanglian is in the form of dried powder or crude extract, the mass ratio of Shuanghuanglian dried powder and beta-cyclodextrin is 1:6-1:3, the mass ratio of Shuanghuanglian crude extract and cyclodextrin is 1:10-1:3, the cyclodextrin can be beta-cyclodextrin or its derivative of hydroxypropyl-beta-cyclodextrin, or SBE-beta-cyclodextrin, in an embodiment, a mixture of multiple effective compositions containing no cyclodextrins is obtained through de-inclusion of inclusion compounds. The invention also provides the process for preparing the composition.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine extract, in particular to a cyclodextrin supramolecular composition of the traditional Chinese medicine Shuanghuanglian, and a preparation method of the composition. Background technique [0002] Shuanghuanglian is a compound traditional Chinese medicine that is compatible with honeysuckle, scutellaria baicalensis and forsythia. At present, the preparations in the Chinese Pharmacopoeia (2000 edition) mainly include oral liquid, granules, suppositories, injections and other dosage forms. Shuanghuanglian has the functions of clearing away heat and detoxifying, clearing away wind-heat, clinically used for wind-heat due to exogenous pathogenic factors, evil in the lungs, heat and toxins in the body, symptoms include fever, slight aversion to wind-cold or no aversion to cold, cough shortness of breath, expectoration yellow in color , sore throat; acute upper respiratory infection, acute bronch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K47/40A61P11/04A61P11/00A61P31/04A61P31/12
Inventor 任勇董祥玉殷志敏
Owner NANJING NORMAL UNIVERSITY