Method for preparing aqueous nontoxic degradable polyurethane elastomer

Abstract

The preparation method of the water-based non-toxic and degradable polyurethane elastomer disclosed by the present invention is to first heat up the polymer diol, and vacuum dehydrate it, then lower the temperature, and then add diisocyanate and catalyst to carry out prepolymerization reaction; after the reaction is completed, the Under strong stirring, add water to emulsify, or cool down again after prepolymerization, and add low molecular weight chain extender I to carry out chain extension reaction, then under strong stirring, add water to emulsify, at the same time add low molecular weight chain extender II to extend again chain, and drop neutralizing agent to neutralize the generated carboxyl groups, and finally mold the obtained emulsion to obtain non-toxic and degradable polyurethane elastomer. The present invention does not use organic solvents, uses aliphatic or alicyclic diisocyanates as raw materials, and uses non-biologically toxic sodium hydroxide and potassium as neutralizers, so that the obtained elastomer can be degraded into small particles that can be normally metabolized by the human body. Molecular substances can also be made into completely non-toxic polyurethane products, which can be widely used as medical polymer materials, especially as tissue engineering materials.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of polyurethane elastomers, and in particular relates to a preparation method of water-based non-toxic and degradable polyurethane elastomers. technical background [0002] Although polyurethane materials are widely used in the manufacture of long-term implanted medical devices and artificial organs, such as artificial heart valves, due to their excellent mechanical properties, wear resistance, lubricity, fatigue resistance, biocompatibility, and processability, etc. , artificial cardiac pacemaker insulated wire, artificial blood vessels, artificial vascular stents, artificial joints, artificial skin, artificial cartilage, etc. However, these non-degradable materials need a second surgery to remove them after performing their mission, which will undoubtedly Cause secondary trauma and pain to the patient. [0003] With the development of biomaterials, people increasingly hope that the ...

AI Technical Summary

Problems solved by technology

However, these methods have a common disadvantage: the synthesis of polyurethane is carried out in organic solvents, which will not only pollute the environment, but also increase the production cost of the product.

The water-based polyurethane emulsion obtained by the above two methods uses aromatic diisocyanate TDI and MDI in the preparation process, which will not only cause the emulsion and the product to turn yellow during storage, but the product will also produce carcinogenic anilines during use. Substances, which limit its normal use as a medical device, this may be the main reason why their finished products have not really been marketed until now

At the same time, in the polyurethanes introduced in these patents, when the soft segments are all stable monomers, such as polyethylene glycol, polypropylene glycol, etc., non-degradable polyurethanes are obtained, which also limits their application in tissue engineering

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