Method for separating and purifying erythromycin

A technology for erythromycin and separation materials, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as separation of erythromycin by ion-exchange fibers without prompting, and achieve fast regeneration speed and environmental pollution. Small, cost-reducing effect

Active Publication Date: 2009-09-09
桂林正翰科技开发有限责任公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The use of ion exchange fibers to separate erythromycin is not suggested in the prior art

Method used

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  • Method for separating and purifying erythromycin
  • Method for separating and purifying erythromycin
  • Method for separating and purifying erythromycin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] Weakly acidic cation exchange fibers and strongly basic anion exchange fibers were prepared by the above method.

[0036] After pretreatment of weakly acidic cation exchange fibers and general-purpose macroporous adsorption resin (1300-I), erythromycin was separated and extracted from the fermentation broth, and the yield and regeneration of erythromycin were compared between the two materials. The specific implementation steps are:

[0037] 1. Wash weakly acidic cation exchange fibers and strongly basic anion exchange fibers with deionized water until the pH value is 7.5-8.0, and set aside; soak the macroporous adsorption resin in ethanol for 3 hours, wash with tap water, and then use sodium hydroxide solution (pH value 9.0-9.5) Soak for 2 hours, wash with tap water until the pH value is 7.5-8.0, and set aside;

[0038] 2. at room temperature, soak the weakly acidic cation exchange fiber and macroporous adsorption resin (1300-1) as separation material processed in abo...

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Abstract

The invention discloses a new method for separating and purifying erythromycin from liquid containing erythromycin by adopting ion exchange fiber with synthetic fiber as the skeleton. The method of the present invention utilizes its special fibrous physical form to make it have a larger contact area with erythromycin, has less resistance to fluids, and utilizes the functional group of ion-exchange fibers to make the adsorption and desorption speed faster, which is faster than the existing The macroporous adsorption resin is easy and thorough in elution, fast in regeneration speed and strong in affinity, achieving the purpose of separation and purification. The application of the method of the invention also solves the problem that the regeneration process is difficult after the macroporous resin absorbs erythromycin, thereby reducing the cost.

Description

field of invention [0001] The present invention relates to a new method for separating and purifying erythromycin, in particular to a method for separating and purifying erythromycin by using a novel functional polymer adsorption material, the functional polymer adsorption material is made of synthetic fibers Weakly acidic cation exchange fibers and strongly basic anion exchange fibers. Background technique [0002] The erythromycin produced by the fermentation method has a low content in the fermentation broth and coexists with various substances, and is usually extracted by solvent extraction. However, due to the high protein content in the fermentation broth, emulsification is prone to occur during the extraction process, so a high-speed centrifugal extraction machine is required, which is expensive, consumes a lot of power, and is expensive to maintain. Based on this, the macroporous network adsorption resin adsorption method is now mostly used to extract erythromycin a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/06
Inventor 冯长根曾庆轩胡秀峰邓琼周从章周绍箕郑波
Owner 桂林正翰科技开发有限责任公司
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