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Method for quantitative analyzing evolution of RNA structure steadiness

A technology for RNA structure and quantitative analysis, applied in the field of computer programs, can solve problems such as difficult quantification and robustness evolution evaluation

Inactive Publication Date: 2009-11-11
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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Problems solved by technology

[0004] The present invention aims to provide a quantitative analysis method that can simply, conveniently and quickly measure the evolution of RNA structural robustness, solve the problems of difficult evolution evaluation and quantification of robustness, and achieve the goal of analyzing the origin and evolution of biological robustness purpose, thereby improving the understanding of biological evolution

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  • Method for quantitative analyzing evolution of RNA structure steadiness
  • Method for quantitative analyzing evolution of RNA structure steadiness
  • Method for quantitative analyzing evolution of RNA structure steadiness

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Embodiment Construction

[0025] Fig. 1 is an overall block diagram of a method for quantitatively analyzing the evolution of RNA structure robustness according to the present invention.

[0026] For the RNA sequence input from the computer terminal, the legality check is performed according to the definition of the RNA sequence. The RNA sequence is a string R=r taken from the alphabet A={A,C,G,U} 1 , r 2 ,...,r n , where r i ∈A, i=1, 2, . . . , n. For input sequences that do not conform to this definition, return to re-input. Adopt the present invention, the example of analysis is the sequence of the microRNA let-7 precursor that length is 1=99 in the nematode:

[0027] UACACUGUGGAUCCGGUGAGGUAGUAGGUUGUAUAGUUUGGAAUAUUACCACCGGU

[0028] GAACUAUGCAAUUUUCUACCUUACCGGAGACAGAACUCUUCGA

[0029] After checking the legitimacy of the RNA sequence input from the computer terminal, along the Hamming distance of the input RNA sequence, select a completely random scrambling method among the five scrambling me...

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Abstract

The present invention relates to a computer program, and more particularly, to a method for the quantitative analysis of the evolution of the robustness of RNA structures. The present invention aims to provide a quantitative analysis method that can simply, conveniently and quickly measure the evolution of RNA structural robustness, solve the problems of difficult evolution evaluation and quantification of robustness, and achieve the goal of analyzing the origin and evolution of biological robustness purpose, thereby improving the understanding of biological evolution. In order to achieve the above object, the present invention uses the RNA secondary structure as a research platform, and provides a method for quantitatively analyzing the evolution of the robustness of the RNA structure in a computer system. The method includes checking the legitimacy of the RNA sequence imported from the computer terminal, Steps to generate control sequences, calculate RNA structural robustness, and quantify the evolution of RNA structural robustness.

Description

technical field [0001] The present invention relates to a computer program, and more particularly, to a method for the quantitative analysis of the evolution of the robustness of RNA structures. Background technique [0002] Biological robustness is one of the most basic and ubiquitous phenomena in biological systems. It is understood as the ability to maintain a stable function in the face of various disturbances. Depending on the nature of the disturbance (heritable or not), robustness can be divided into genetic robustness and environmental robustness. Genetic robustness refers to the insensitivity of phenotype in the face of genetic mutation interference; while environmental robustness refers to the insensitivity of phenotype in the face of interference from external environmental factors. For a long time, biologists have paid great attention to the study of biological robustness, from Fisher's dominant study to Waddington's developmental homeostasis study. Research h...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00G16B10/00
Inventor 王升启舒文杰伯晓晨
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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