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Elemene inclusion complex, preparation and preparation process thereof

A technology of elemene and clathrate, applied in the field of elemene clathrate, can solve problems such as unsuitable taste, and achieve the effects of convenient clinical medication, fast onset of effect, and high quality assurance rate

Inactive Publication Date: 2009-11-18
刘玉辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to overcome the disadvantages of unsuitable taste in the existing elemene pharmaceutical preparations, adopt specific auxiliary materials and proportions to clathrate elemene, and make elemene clathrates and preparations, thereby solving the problem of Elemene has odor and water solubility issues, and it has good stability, water solubility and no irritating odor, making it suitable for clinical applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 A kind of elemene β-cyclodextrin inclusion compound

[0041] Take 10g of elemene, dissolve it in 30ml of ethanol, take 30g of β-cyclodextrin, dissolve it in 120ml of water for injection, gradually add the elemene ethanol solution into the aqueous solution of β-cyclodextrin, and stir magnetically at room temperature After 3 hours, it was filtered with a 0.45um microporous membrane, and the filtrate was freeze-dried to obtain a loose white powder, which was the β-cyclodextrin inclusion compound of elemene. The inclusion rate was 96% as determined by gas chromatography.

Embodiment 2

[0042] Embodiment 2 A kind of elemene microcrystalline cellulose inclusion compound

[0043] Take 10g of elemene, dissolve it in 30ml of ethanol, take 30g of microcrystalline cellulose, dissolve it in 120ml of water for injection, gradually add the elemene ethanol solution into the aqueous solution of microcrystalline cellulose, and stir magnetically for 3 hours at room temperature , filtered through a 0.45um microporous membrane, and the filtrate was freeze-dried to obtain a loose white powder, which is the microcrystalline cellulose inclusion compound of elemene. The inclusion rate was 99% as determined by gas chromatography.

Embodiment 3

[0044] Embodiment 3 A kind of elemene carboxymethyl starch sodium clathrate

[0045] Take 10g of elemene, dissolve it in 40ml of ethanol, take 50g of sodium carboxymethyl starch, dissolve it in 120ml of water for injection, gradually add the elemene ethanol solution dropwise into the aqueous solution of sodium carboxymethyl starch, and place it in an ultrasonic generator. Ultrasonic vibration at room temperature for 20 minutes, filtered with a 0.45um microporous membrane, and the filtrate was freeze-dried to obtain a loose white powder, which is the sodium carboxymethyl starch inclusion compound of elemene, which was determined by gas chromatography. The rate is 97%.

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PUM

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Abstract

The invention relates to an elemene inclusion compound with antiviral and anticancer effects, its preparation and its preparation method. In the elemene inclusion compound, elemene: inclusion material = 1: 1-100, wherein the inclusion material is selected from β-cyclodextrin, microcrystalline cellulose, powdered cellulose, sodium carboxymethyl starch , any one of croscarmellose sodium, hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose or any mixture thereof. The elemene clathrate of the invention is easily soluble in water, has high stability and bioavailability, and has no irritating smell.

Description

technical field [0001] The invention relates to a medicine, in particular to an elemene inclusion compound with antiviral and anticancer effects, its preparation and its preparation method. Background technique [0002] Elemene is an active ingredient extracted from Curcuma phaeocalis Valeton. or Curcumakwangsiensis S.G.Lee et C.F. in Guangxi or Curcuma Wenyujin Y.H.chen et C.Ling or other plants in Zingiberaceae. Its English name is Elemene, and its chemical name is 1 -Methyl-1-vinyl-2,4 diisopropenylcyclohexane, molecular formula: C 15 h 24 . Elemene contains a variety of isomers, mainly α-elemene, β-elemene, γ-elemene, δ-elemene, curcumene, and caryrone. There have been many literature reports on the method of extracting and refining elemene, as described in Chinese patent CN1060038 and Chinese patent CN1200266. [0003] Elemene has antiviral and anticancer effects. Pharmacological tests have proved that elemene has obvious inhibitory effect on a variety of animal tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/40A61K47/38A61K9/08A61K9/02A61K9/20A61K9/48A61K31/015
Inventor 刘玉辉谢瑞钢
Owner 刘玉辉
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