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Silkworm health-care product and its preparing process

A technology of health care products and silkworms, which can be used in the fields of pharmaceutical formulations, bulk delivery, drug delivery, etc., and can solve problems such as inconvenient taking

Inactive Publication Date: 2007-09-19
中国农业科学院上海家畜寄生虫病研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no convenient and effective silkworm health product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0069] Add 150 mL of water to 52 grams of frozen silkworms, crush them with a tissue grinder, boil for 5 minutes, adjust the pH to 8.0 with NaOH after cooling, add trypsin, mix well, digest for 3 hours, and boil for 2 minutes to inactivate the enzyme. After cooling, adjust the pH to 4.0-5.0 with 10N HCl, add pepsin, digest for 3 hours, and boil for 2 minutes to inactivate the enzyme. Filter through 2 layers of gauze and squeeze dry, collect the aqueous phase and filter through qualitative filter paper to remove all particles. Adjust the pH to 7.0 and perform ultrafiltration. Obtain 150mL product, its amino acid (polypeptide) content is 57mg / mL, the inhibitory rate to glycosidase enzyme activity is 84.81%, and uric acid content is 27mg / L.

[0070] Take 50 μ L sample in relevant steps, dilute 1 times with water, carry out the inhibition test of glycosidase, the result shows that this method fully retains the active ingredient (see table below) that can inhibit glycosidase in si...

preparation example 2

[0076] 156 grams of cryopreserved silkworms were added to 150 mL of water, digested by the above method, diluted to 330 mL with water after ultrafiltration, and its amino acid (polypeptide) content was 54 mg / mL, the inhibition rate of glycosidase enzyme activity was 85.61%, and the uric acid content It is 29mg / L.

Embodiment 2

[0078] Observation on the reduction of uric acid in health products

[0079] Because the silkworm has no urination organ, the content of uric acid in the silkworm is relatively high, and urate is the main cause of gout, so we have measured the reduction of uric acid in the sample prepared by the method of the present invention: get 2 silkworms (6.3g), add 15mL 0.05M NaOH, lyse with a homogenizer, keep warm in a water bath at 80°C for 1 hour, centrifuge at 10,000 rpm for 20 minutes, take the supernatant, dilute it with 0.05M NaOH to a volume equivalent to 6.3g silkworm health care solution (20mL), and use Uric acid assay kit (purchased from Shanghai Rongsheng Biotechnology Co., Ltd.) measures the uric acid content in the sample and the health care solution. As a result, the uric acid content in the sample is 139.42 mg / L, and the uric acid content in the health care solution prepared by the method of the present invention is 27.20 mg / L. mg / L, it shows that the uric acid of 80.5%...

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PUM

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Abstract

The invention provides a health product having function of treating and preventing diabetes, which is prepared by five instar of silkworm, in particular relates to a preparing method of digesting the five instar silkworm by proteinase and a preparation formed by the method. The preparation with abundant nutrientsubstances, amino acid required by human body and effective ingredient to decrease blood sugar has excellent prevention effect from hyperglycemia and excellent treatment effect after the hyperglycemia generating (Type II diabetes), thus is an ideal blood sugar modulator. The method of the invention has advantages of low production cost, good effect, safety, convenience for take the medicine, controllable quality, etc.

Description

technical field [0001] The invention relates to a health care product, in particular to a health care product with the effects of treating and preventing diabetes prepared by using the 5th instar silkworm and a preparation method thereof. Background technique [0002] Diabetes Mellitus (DM) is a common chronic endocrine and metabolic disease, characterized by hyperglycemia and glucosuria, clinically manifested as polydipsia, polyphagia, polyuria, and weight loss. , Chinese medicine is called quenching thirst. [0003] Diabetes is a disease of the rich. In recent years, with the improvement of people's living standards, the incidence of diabetes has been increasing year by year. Type II diabetes accounts for 85%-95% of the total diabetes in the world, while the incidence rate in China is over 90% [see Guo Xiaohua et al., Type 2 diabetes rat model induced by high-sugar and high-fat diet and its nephropathy characteristics, Diabetes in China Journal, 2002, Vol. 10, No. 5, 29...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/08A61K9/16A61K9/20A61K9/48A61P3/10
Inventor 刘金明傅志强怨纯秀蔡幼民林矫矫
Owner 中国农业科学院上海家畜寄生虫病研究所
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