Medicament

A drug and a technology for preparing a drug, applied in the field of pharmaceutical compositions and preparing such drugs, can solve problems such as unfavorable alternative sources, composition handling and processing imposition, etc.

Inactive Publication Date: 2007-10-24
AIMSCO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is already disadvantageous in terms of isolating active components for further research and development of possible alternative sources of active components
Moreover, it has been necessary to treat patients in the form of serum, which requires injections and imposes certain restrictions on the handling and processing of the composition

Method used

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Experimental program
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Embodiment Construction

[0073] Preparation of serum composition

[0074] Approximately 400 cc of blood was drawn from goats under aseptic technique. Typically, animals are bled again at 10-14 days once the blood volume has been replenished. A prebleed protocol is useful to stimulate the production of active components of serum. The serum is then centrifuged to separate the serum, which is then filtered to remove large clots and specific substances. The serum was then treated with supersaturated ammonium sulfate (47% solution at 4°C) to precipitate antibodies and other materials. The resulting solution was centrifuged at 3500 rpm for 45 minutes in a Beckman J6M / E centrifuge, after which the supernatant was removed. Precipitated immunoglobulins and other solid material are resuspended in PBS buffer (phosphate buffered saline) sufficient to redissolve the pellet.

[0075] The solution was then diafiltered against PBS buffer at 4°C with a molecular weight cut off of 10,000 Daltons. After diafiltrati...

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Abstract

Analysis of a goat serum product with many therapeutic effects is described. The product is identified as containing proopiomelanocortin (POMC) and Corticotropin releasing factor (CRF) peptides, as well as breakdown products of these peptides. We describe methods of treatment of diseases including cancers, multiple sclerosis, and neural disorders using these peptides and their products, as well as medicaments including such peptides and methods of producing the peptides.

Description

field of invention [0001] The present invention relates to a medicine, in particular to a medicine composition. Although many other diseases can be treated using the present invention, it is believed that the drug is particularly suitable for the treatment of neurological diseases. Aspects of the invention also relate to methods of preparing such medicaments, methods of using said medicaments to treat diseases. Background of the invention [0002] PCT Publication Nos. WO03 / 004049 and WO03 / 064472 describe therapeutics and treatments based on serum compositions that have many surprising beneficial effects. The respective contents of each of these two applications are hereby incorporated by specific reference in their entirety. In particular, the reader refers to them to understand how therapeutic agents may be prepared, and to learn about diseases that may be treated. [0003] Typically, goats are immunized with HIV-3B viral lysates produced in H9 cells. The resulting seru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/35A61K38/095
CPCA61K31/00A61K38/11A61K38/34A61K38/2228A61K38/22A61K38/33A61K38/095A61P1/04A61P1/16A61P11/00A61P13/12A61P15/08A61P17/00A61P17/06A61P19/02A61P21/00A61P21/04A61P25/00A61P25/06A61P25/08A61P25/14A61P25/18A61P25/24A61P25/28A61P27/02A61P27/16A61P29/00A61P3/02A61P3/04A61P31/00A61P35/00A61P37/02A61P37/06A61P37/08A61P43/00A61P7/00Y02A50/30A61K2300/00
Inventor D·麦金托什
Owner AIMSCO LTD
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