Lab-on-a-chip for an on-the-spot analysis and signal detection methods for the same

A lab-on-a-chip and signal technology, which is applied to laboratory equipment, laboratory containers, analytical materials, etc., can solve problems such as time delay

Inactive Publication Date: 2007-11-14
BIODIGIT LAB CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since several aspects of this technology have not yet been developed, such as the reproducibility of mass production of chips, the time for its practical application is greatly delayed (references: O.A.Schueller et al., 1999, Sens.Acuat .A Issue 72, pages 125-139)

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  • Lab-on-a-chip for an on-the-spot analysis and signal detection methods for the same
  • Lab-on-a-chip for an on-the-spot analysis and signal detection methods for the same
  • Lab-on-a-chip for an on-the-spot analysis and signal detection methods for the same

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Embodiment Construction

[0076] [76] The following examples illustrate the content of the present invention more specifically, and demonstrate its practicability by demonstrating specific applications, but by no means limit the scope of the present invention. In particular, it has been applied to the immunoassay of an analyte requiring higher sensitivity, namely cardiac troponin I (cTnl), as a specific marker for acute myocardial infarction (AMI).

[0077] [77] Materials used in the example

[0078] [78] Polymethyl methacrylate (PMMA) was obtained from LG Chem (PMMA IF870, Seoul, Korea). Cardiac troponin (cTn) I-T-C complex master solution, cTn1 monomolecule for immunization and cTn1-specific monoclonal antibody (Clone 19C7) were supplied by Hytest (Turku, Finland). Human anti-mouse antibody (HAMA) blockers (mouse IgG fragments) and myocardial marker controls were obtained from Chemicon International (Temecula, CA) and Cliniqa (Fallbrook, CA), respectively. Purchase N-succinimide-3-(2-pyridyldithio)...

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Abstract

The present invention relates to a lab-on-a-chip version of biosensor for an on-the-spot analysis whose analytical performances were remarkably improved, by incorporating commercial membranes, traditionally used for rapid diagnostics, into microfluidic channels engraved on the surface of a plastic chip, as follows: 1) reduction of sample size; 2) realization of variable functions for total analysis; and 3) transfer of medium by capillary action without the assistance of an external force.

Description

technical field [0001] [01] The present invention relates to a lab-on-a-chip version of a biosensor for on-site analysis by incorporating commercially available membranes traditionally used for rapid diagnostics into microfluidic channels carved on the surface of a plastic chip, with analytical performance in the following Significant improvements have been made in: 1) reduced sample size; 2) variable functionality for full analysis; and 3) transport of media by capillary action without resorting to external forces. Background technique [0002] [02] Traditionally, rapid analytical devices based on chromatography using culture medium flowing laterally through micropores present in membrane mat matrices have been applied to the diagnosis of various diseases and conditions (references: S.H.Paek et al. , 2000, Methods No. 22, pp. 53-60; S.H.Paek et al., 1999, Biotechnol. Bioeng. No. 62, pp. 145-153; Y. Kasahara et al., 1997, Clin. Chimi. Acta pp. 267, pp. 87-102). Despite its...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/536G01N33/58
CPCG01N33/54366B01L3/502707B01L2300/0825B01L2300/0627B01L2300/0645B01L2300/0681B01L2400/0406B01L2300/0887B01L3/50273B01L3/5023B01L3/502715B01L2200/10
Inventor 白世焕金周垠
Owner BIODIGIT LAB CORP
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