7-azaindirubin and 7-azaisoindigo derivative, its production and pharmaceutical use

A derivative, indirubin technology, is applied in the field of preparation of 7-azadirubin and 7-azaisoindigo derivatives and their pharmaceutical uses, which can solve problems such as poor fat solubility, improve physical and chemical properties, improve Bioavailability, the effect of enhancing cell permeability

Active Publication Date: 2007-11-21
JC (WUXI) CO INC
View PDF1 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, indirubin-like bisindole compounds are an important class of CDKs inhibitors with low toxicity and side effects, but their fat-solubility and water-solubility are poor, which affects their clinical application. In recent years, foreign Many pharmaceutical research institutes and pharmaceutical companies have carried out extensive structural modifications to indir...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 7-azaindirubin and 7-azaisoindigo derivative, its production and pharmaceutical use
  • 7-azaindirubin and 7-azaisoindigo derivative, its production and pharmaceutical use
  • 7-azaindirubin and 7-azaisoindigo derivative, its production and pharmaceutical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0063] 1. Instruments and reagents

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Yieldaaaaaaaaaa
Login to view more

Abstract

A method for designing and synthesizing 7-azaindirubin and 7-azaisoindigo derivative and its medicinal use are disclosed. It changes indirubin and isoindigo nuclear-parent molecule atomic composition to form into compound. It also changes original molecule electric property. The process is carried out by coupling at different position by 7-azaindole and indole bi-molecule, inhibiting CDKs and CDKIs growth and breed and inducing CDKIs biological function. It can be used to treat malignant tumor, HIV and nervous system diseases.

Description

technical field [0001] The present invention relates to a method for designing and synthesizing a class of novel structure 7-azaidirubin and 7-azaiisoindigo derivatives and their pharmaceutical application. The common feature of these molecules is that they are all formed by coupling 7-azaindole and indole bimolecules at different positions, and inhibit cell growth and proliferation through various mechanisms, including inhibition of cyclin-dependent kinases ( Cyclin-dependent kinases, referred to as cell cycle kinases, abbreviated as CDKs), inducing endogenous cell cycle kinase inhibitors (CDKIs) and other biological functions, and then have the ability to treat various diseases caused by cell growth disorders, including malignant tumors, Neurological diseases such as viral skin diseases, HIV, neurodegeneration and disorders, etc. Background technique [0002] The cyclin-dependent kinases (cyclin-dependent kinases, abbreviated as cell cycle kinases, abbreviated as CDKs) fa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D471/04A61K31/437A61P35/00
CPCC07D471/04A61P17/00A61P17/06A61P25/00A61P31/18A61P35/00A61P37/00A61P43/00A61P5/50A61P3/10
Inventor 姚其正王朝晖程景才华维一
Owner JC (WUXI) CO INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap