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Technics for extracting lotus leaf flavone

A lotus leaf flavonoids and process technology, applied in the field of extracting lotus leaf flavonoids, to achieve the effects of reducing interference, enhancing adsorption capacity, and safe extraction methods

Inactive Publication Date: 2010-07-28
江苏科乐欣生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drawbacks of existing researches and patented technologies on the extraction of lotus leaf flavonoids resins are that no fat-soluble impurities have been extracted before adsorption with macroporous resins, let alone macromolecular impurities. , so that the resin adsorption is not suitable for industrial production, and the purity of the obtained product is not good; secondly, the desorption does not consider that the lotus leaf flavonoids are a type of compound with different structures and different polarities, and the lotus leaf flavonoids are not washed step by step. Deseparation, separation and removal of impurities is not specific enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The fresh lotus leaves harvested on site were washed, air-dried or dried, and crushed to obtain lotus leaf powder; 5 kg of lotus leaf powder was leached with 125 L of 60% ethanol aqueous solution at a temperature of 75 ° C for 40 minutes, and the filtrate was collected, and the filter residue was leached with 75 L Extract again with 60% ethanol, and combine the two filtrates; concentrate the extract under reduced pressure to about 50L, recover ethanol, and filter to remove water-insoluble impurities; extract the concentrated and filtered extract with 33.3L petroleum ether (boiling range 60°C) The two are 50,000 ultrafiltration membranes for ultrafiltration. The ultrafiltration process conditions are: operating temperature at room temperature, ultrafiltration pressure 0.15MPa, when the ultrafiltration retains the liquid, adjust the pH of the raffinate to 9, and filter to remove a small amount of precipitation; add 100L After diluting with water, reduce it to about 20L wit...

Embodiment 2

[0027] The fresh lotus leaves harvested on site were washed, air-dried or dried, and crushed to obtain lotus leaf powder; 5 kg of lotus leaf powder was leached with 150 L of 60% ethanol aqueous solution at a temperature of 70 ° C for 60 minutes, and the filtrate was collected, and the filter residue was leached with 50 L 60% ethanol was extracted again, and the filtrate was combined twice; the extract was concentrated under reduced pressure to about 50L, the ethanol was recovered, and water-insoluble impurities were removed by filtration; the concentrated and filtered extract was extracted with 35L petroleum ether (boiling range 60°C) Perform ultrafiltration for 50,000 ultrafiltration membranes. The ultrafiltration process conditions are: operating temperature at room temperature, ultrafiltration pressure 0.15MPa, when the ultrafiltration retains the liquid, adjust the raffinate to pH8, and filter to remove a small amount of precipitation that occurs; add 100L of water After di...

Embodiment 3

[0030] The fresh lotus leaves harvested on site were washed, air-dried or dried, and crushed to obtain lotus leaf powder; 5kg of lotus leaf powder was extracted with 125L of 50% ethanol aqueous solution at a temperature of 80°C for 40 minutes, and the filtrate was collected, and the residue was extracted with 50L of 50% ethanol was extracted again, and the filtrate was combined twice; the extract was concentrated under reduced pressure to about 40L, the ethanol was recovered, and water-insoluble impurities were removed by filtration; the concentrated filter extract was extracted with 40L petroleum ether (boiling range 60°C) Perform ultrafiltration for 50,000 ultrafiltration membranes. The ultrafiltration process conditions are: operating temperature at room temperature, ultrafiltration pressure 0.15MPa, when the ultrafiltration retains the liquid, adjust the pH of the raffinate to 9, and filter to remove a small amount of precipitation that occurs; add 100L of water After dilut...

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Abstract

The invention relates to a process of extracting flavone from lotus leaf, which comprises following steps: deposition-extraction-ultra-filtering-micro porous absorption resin column: condensing and dealcoholizing to remove water insoluble foreign matter through depostion, extracting with ligarine to remove fat soluble foreign matter, ultra-filtering to remove water soluble micro-molecular foreignmatter, using macroporous absorption column to absorb chromocor selectively, washing and collecting different types of high-purity chromocor. The invention is characterized in that it removes water insoluble foreign matter through deposition, and removes fat soluble foreign matter through extraction with benzinum purificatum, and eliminates water soluble macromolecular foreign matter through ultra filtering membrane, after the processes, the foreign matter is effectively removed from upper column and reduces influence to resin absorption, the absorption performance to chromocor is greatly improved, the absorption volume is increased from 83mg / ml to 200 mg / ml. It is suitable for mass production.

Description

Technical field [0001] The present invention involves a preparation process from natural plants to extract total flavonoids from the lotus leaf, especially with sedimentation, ultrafiltration, and large holes adsorption resin technology to extract total lotus leaf flavonoids and eluted different types of lotus leaves step by step to collect different types of lotus leaves.The method of preparation of flavonoids is suitable for large -scale production. Background technique [0002] Basic studies of lotus leaf medicine have confirmed that lotus leaves have a certain effect of weight loss and lipid -lowering. The soings and decoction of lotus leaves can directly diffuse blood vessels, causing moderate pressure reduction. Lotus leaves have a lowering effect.Obesity.Lotus leaf contains biological active ingredients such as flavonoids, alkaloids, and pyrum compounds.These ingredients have a very strong antioxidant effect, can remove excess free radicals in the organism, prevent lipid ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/62C07D311/30C07D311/04C07H17/06A61P9/12A61P3/04
Inventor 黄阿根董瑞建韦红刘国建
Owner 江苏科乐欣生物有限公司