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Method of preventive treatment of allergy by oromucosal administration of an allergy vaccine

An allergy, preventive technology, applied in the direction of allergen antigen components, etc., can solve life-threatening problems

Inactive Publication Date: 2008-01-02
ALK ABELLO SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After each injection, the patient must be under medical supervision for 30 minutes due to the risk of allergic side effects, which, although extremely rare in principle, can be life-threatening
In addition, clinics must be equipped to support emergency treatment

Method used

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  • Method of preventive treatment of allergy by oromucosal administration of an allergy vaccine
  • Method of preventive treatment of allergy by oromucosal administration of an allergy vaccine
  • Method of preventive treatment of allergy by oromucosal administration of an allergy vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: Prophylactic treatment of SAV in mice involving sublingual and parenteral administration

[0094] animal

[0095] Female, 6- to 10-week-old BALB / c mice are housed in house and fed a defined diet that does not contain components that cross-react with the Ph1p antiserum. Each experimental group consisted of 8 to 10 animals.

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Abstract

The present invention relates to a method of preventive treatment of allergy to an allergen in a subject comprising a) administering an allergy vaccine containing the allergen as active substance to the subject via an oromucosal route, b) wherein the subject to be treated is unsensitised in the sense of exhibiting no IgE response specific to the allergen, c) wherein the subject to be treated is free of clinical symptoms of any allergy, and d) wherein the preventive treatment is aimed at preventing or reducing subsequent clinical symptoms of the allergy associated with the allergen.

Description

technical field [0001] The present invention relates to a method of prophylactic treatment of hypersensitivity to allergens in a subject. Background of the invention [0002] Allergies are an important health problem in countries adapted to a western lifestyle. Moreover, the prevalence of allergic diseases is increasing in these countries. Although allergies are not generally considered a life-threatening disease, asthma is responsible for a considerable number of deaths each year. The abnormal prevalence of approximately 30% among adolescents results in significant loss of quality of life, workdays and money and has led to its classification as a major health problem in the Western world. [0003] Allergy is a complex disease. Many factors contribute to sensitization events. Among these are individual susceptibilities defined by the interactions between several genes that are not well understood. Another important factor is allergen exposure above a certain threshold. ...

Claims

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Application Information

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IPC IPC(8): A61K39/35
Inventor J·布里莫内斯J·基尔德斯加德
Owner ALK ABELLO SA
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