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Rapid and sensitive biosensing

A sensor device and surface-combined technology, applied in the field of sensors, can solve problems such as disturbing the orientation of the sensor, and achieve the effects of improving detection speed and high sensitivity

Inactive Publication Date: 2008-01-23
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, large magnetic fields may disturb the orientation of the sensor due to its difficult-to-control characteristics and introduce magnetic build-up in the sensor

Method used

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  • Rapid and sensitive biosensing
  • Rapid and sensitive biosensing
  • Rapid and sensitive biosensing

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Embodiment Construction

[0073] The present invention will be described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. Any reference signs in the claims should not be construed as limiting their scope. The drawings described are non-limiting schematic representations only. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. The word "comprising" used in the present description and claims does not exclude other elements or steps. Where an indefinite or definite article is used to limit a singular noun, it includes a plural of said noun unless expressly stated otherwise.

[0074] Furthermore, the terms first, second, third, etc. in the description and claims are used to distinguish similar elements and are not necessarily intended to describe a sequential or chronological order. It is to be understood that the terms so used are interchangea...

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Abstract

A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and comprises: at least one sensor element (23) for detecting the presence of magnetic particles (13), means for attracting magnetic structures comprising at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and means for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.

Description

technical field [0001] The present invention relates to sensors, in particular biosensors, and more particularly to magnetically actuated "attraction" and / or "binding" steps in biosensing processes employing such biosensors. Background technique [0002] Both the central laboratory and clinical medical diagnosis are characterized by integration and automation trends. The reason for this is that testing must be made easy to perform in a reliable, cost-effective manner with minimal human intervention. At the same time, the demand for higher sensitivity and detection specificity is constantly increasing. [0003] Magnetic biochips are proposed as a novel device for sensitively detecting low concentrations of target molecules in body fluids for diagnosis. Such magnetic biochips have potentially favorable properties for application in biomolecular diagnostics in terms of sensitivity, specificity, integration, ease of use, and cost. For example, sensitive magnetoresistive magne...

Claims

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Application Information

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IPC IPC(8): G01N33/553G01N33/543
CPCG01N27/745G01N33/54333G01N33/553
Inventor J·A·H·M·卡尔曼R·E·蒂尔温德M·W·J·普林斯M·梅珍斯R·温贝格尔－弗里德尔
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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