Surface injection device

A delivery device, body surface technology, applied in the field of surface injection devices, can solve the problems of broken needles, embedded in animals, contamination, etc.

Active Publication Date: 2008-02-20
MASSACHUSETTS INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods suffer from several major drawbacks: localized skin damage, bleeding, risk of infection at the injection site, and the resulting problem of contaminated needles and s...

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Embodiment Construction

[0029] The following is a description of preferred embodiments of the present invention.

[0030] A percutaneous delivery device, or injection device, is configured to deliver a substance across the surface of an organism. Injection devices include devices having one or more needles (eg, hypodermic device needles) configured to pierce the skin prior to injecting a substance. Other injection devices are configured for injecting a substance under the skin without first piercing the skin with a needle (eg, needleless). It will be noted that the term "needle-free" as used herein refers to a device that injects without first piercing the skin with a needle. Thus, a needle-free device may include a needle, but the needle is not used to pierce the skin in the first place. Certain needle-free injection devices rely on a pioneer propellant expelled from the device to first pierce the skin. Other needle-free injection devices rely on the pressure provided by the drug itself.

[0031...

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Abstract

A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .

Description

technical field [0001] This application claims the benefit of US Provisional Application No. 60 / 652,483, filed February 11, 2005. The entire teachings of the aforementioned applications are incorporated herein by reference. Background technique [0002] Injecting a fluid (eg, a drug) into a patient or agricultural animal can be done in a variety of different ways. One of the easiest modes of drug delivery is through the skin, the outermost protective layer of the body. The skin includes the superficial layers, which include the stratum corneum, the granular layer, the spinous layer, the basal layer, and the dermis, which includes the capillary layer. The stratum corneum is a rough, scaly layer made of dead tissue. The stratum corneum extends approximately 10-20 microns outward from the skin surface and has no blood supply. Because of the thickness of this cell layer, it is very difficult to transport compounds across the skin into and out of the body. [0003] Current m...

Claims

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Application Information

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IPC IPC(8): A61M5/30
CPCA61M5/30A61M5/3291A61M5/3007
Inventor 伊恩·W·亨特安德鲁·J·塔伯纳布赖恩·D·赫蒙德道恩·M·温德尔内森·B·鲍尔诺拉·凯瑟琳·霍根
Owner MASSACHUSETTS INST OF TECH
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