57results about How to "Injection volume is small" patented technology

The invention concerns a suspension of biocompatible particles for carrying active principles. Said carrier particles are based on a double-block hydrophilic neutral polyaminoacid/hydrophobic neutral polyaminoacid copolymer. Said hydrophilic neutral polyaminoacid/hydrophobic neutral polyaminoacid particles are capable of combining in colloidal suspension in non-dissolved state, at least an active principle and of releasing same, in particular in vivo, in prolonged and/or delayed delivery. The invention also concerns a powdery solid from which are derived the carrier particles and the preparation of said solid and of said suspension of active principle based on hydrophilic neutral polyaminoacids/hydrophobic neutral polyaminoacids. Said carrier particles form spontaneously and in the absence of surfactants or organic solvents, stable aqueous suspensions. The invention also concerns the carrier particles in dry form, the method for preparing them, and pharmaceutical compositions (in dry form or suspension) comprising said carrier particles associated with an active principle.

The invention relates to a detecting tube for low concentration ammonia gas. Barium sulfate, silica gel or a mixture of the barium sulfate and the silica gel is used as a carrier; thymolsulfonphthalein and methylthymol blue are used as color reagents. The ammonia gas samples with different concentrations flow into the detecting tube; the content of the ammonia gas is determined by different colorsof the color reagents; and the detecting tube has simple structure, quick analysis, low cost and convenient to carrying, and can detect whether the content of the ammonia gas in the environmental airon-site is over-proof at the field. The application experiment shows that the detecting tube has higher sensitivity and substantially meets the requirements of national standard.

The invention relates to the field of rapid detection of food safety and particularly relates to a preparation method and application of an electrochemical sensor based on a cobalt oxide/mesoporous carbon nanocomposite material and application of the electrochemical sensor in fast detection of nitrite content in a food. The preparation method of the electrochemical sensor comprises preparing a nanocomposite material carrying cobalt oxide particles and graphitized mesoporous carbon, and modifying a work electrode of the electrochemical sensor. The electrochemical sensor can detect a standard solution of nitrite, determine the linear relationship between the nitrite concentration and current, determine nitrite in the food and compare the nitrite content in the food and the linear relationship to obtain nitrite content of the food to be detected. The electrochemical sensor can determine nitrite content of a food, is easy to operate, has a fast detection rate and high detection sensitivity and provides a novel detection method for efficient and rapid detection of nitrite content in a food.

The invention relates to a low-molecular-weight heparin molecular weight and molecular weight distribution detection method. High performance liquid chromatography is used, the method includes the following steps that firstly, a low-molecular-weight heparin sodium standard substance solution is prepared; secondly, a low-molecular-weight heparin sodium molecular weight calibration standard solution is prepared; thirdly, a test sample solution is prepared; fourthly, a 0.01% sodium azide solution is prepared; fifthly, the 0.01% sodium azide solution, the low-molecular-weight heparin sodium standard substance solution, the low-molecular-weight heparin sodium molecular weight calibration standard solution and the test sample solution are injected into a high performance liquid chromatograph respectively to obtain a chromatogram, the molecular weight of a test sample is calculated and a molecular weight distribution result is obtained according to the chromatogram.

The invention discloses a high performance liquid chromatography method for analysis of alkyl chloride compound. The analytical conditions are as below: chromatography column uses a polysaccharide coated chiral chromatographic column; a mixed solution containing a derivative reagent, a sample to be measured and a diluent is used as the solution to be measured; a first mixed solution containing a first organic solvent and a second organic solvent is used as a mobile phase; a mixed solution containing a first organic solvent and a second organic solvent is used as a diluent; and the first organic solvent is an organic hydrocarbon solvent, and the second organic solvent is an organic alcohol solvent. The method can fast and efficiently separate enantiomers of alkyl compounds, and effectively control of the quality of chiral acyl chloride compounds. The detection method has the advantages of high sensitivity, good repeatability, high accuracy, wide application range, low cost and convenient operation, and can effectively control the product quality.

The invention discloses a method for distinguishing tubercular meningitis and virus meningitis based on a nuclear magnetic resonance technology and application thereof. According to the method, nuclear magnetic resonance detection is conducted on the cerebrospinal fluid of a patient to be detected to obtain relative expression quantities of difference metabolites represented by chemical shifts of 3.50 ppm, 3.76 ppm, 3.05 ppm, and 2.79 ppm respectively, and then whether the patient suffers from the tubercular meningitis or the virus meningitis is distinguished according to the relative expression quantities of the difference metabolites. Compared with the prior art, the method has the advantages of being simple in sample treatment, free of sample damage, small in sample quantity, good in repeatability, low in cost and the like.

The invention provides a micro-fluidic chip for detecting glycosylated hemoglobin and a detection method thereof. The micro-fluidic chip is sequentially provided with a cover plate layer, a fluid layer with a hollow channel structure and a substrate layer from top to bottom, and the hollow channel structure and the substrate layer jointly form a sample detection unit. A sample injection through hole and a waste liquid leading-out through hole are respectively formed in the cover plate layer. The sample detection unit comprises one or more sample injection chambers, a dilution chamber, an affinity chromatography channel, a detection chamber and a waste liquid pool. The sample injection through hole is communicated with the sample injection chamber, and the waste liquid leading-out through hole is communicated with the waste liquid pool. Sample introduction, sample dilution and optical and electrical detection are integrated through the micro-fluidic chip; the operation process is greatly simplified, the consumption of samples and reagents is reduced, expensive equipment is not needed, the use cost is largely reduced, the on-site instant detection of glycosylated hemoglobin can be realized, and huge economic value and social value are created.

The invention relates to a method for simultaneous rapid determination of the content of nine kinds of alcohol compounds in edible flavors and fragrances by a GC-MS method, and belongs to the field ofanalytical chemistry. According to the method for simultaneous rapid determination of the content of the nine kinds of the alcohol compounds in the edible flavors and fragrances by the GC-MS method,a gas chromatography-mass spectrometer is adopted, deuteration-1-propyl alcohol-1,1,3,3,3-d<5> is taken as an internal standard, split sampling at the ratio of 20 to 1 is carried out, temperature programming is carried out, and an SIM scanning model establishes the method for rapid determination of the content of the nine kinds of the alcohol compounds in the flavors and fragrances; by analyzing,the nine kinds of the alcohol compounds have a good liner range within 0.2-50 mg/L, the correlation coefficients are all 0.993 or above, the quantitative limit is within 0.65-1.01 mg/kg, the average recovery rate of a standard addition experiment is within 87.9%-105.2%, and the relative standard deviation is within 2.01%-4.83%; and results indicate that the method is simple, rapid and accurate, and is suitable for simultaneous analysis determination of the nine kinds of the alcohol compounds in the edible flavors and fragrances.

A device to assay the chemical oxygen demand catalyzed by photoelectricity belongs to the environment analysis chemical and sensor technology field. The analyzing detection device which can receive the ultraviolet light irradiation and the working electrode with the photoelectricity co-catalyzing activity is be used with the traditional flow injecting sampling system and the data processing system. when the ultraviolet light illuminates the working electrode, the computer starts and controls the electrochemical workstation to give +1.1-+1.5V working potential on the working electrode. In the selective flow injecting analyzing condition, a quantity of water sample flow the working electrode, the workstation collects the current response signal of the working electrode which quantity the water chemical oxygen demand.

The invention relates to equipment for treating unsymmetrical dimethylhydrazine-containing wastewater. The equipment comprises a wastewater conveying mechanism, a flow detection mechanism, a concentration detection mechanism, a catalyst sampling mechanism, a degradation reaction mechanism and a control mechanism. The degradation reaction mechanism is respectively communicated with the wastewater conveying mechanism and the catalyst sampling mechanism through pipelines, and the degradation reaction mechanism is used for degrading unsymmetrical dimethylhydrazine in the wastewater; and the control mechanism is electrically connected with and controls the wastewater conveying mechanism and the catalyst sampling mechanism, and is used for adjusting the flow of the wastewater and the sampling amount of the catalyst according to the concentration of unsymmetrical dimethylhydrazine in the wastewater. When the concentration of unsymmetrical dimethylhydrazine in the wastewater is large, the flow of the wastewater can be properly reduced and the sampling amount of the catalyst can be increased, and on the contrary, the flow of the wastewater can be properly increased and the sampling amount of the catalyst can be properly reduced. Therefore, the unsymmetrical dimethylhydrazine amount treated in unit time in the degradation reaction mechanism is relatively stable, so that the fluctuation of each discharge index of the treated wastewater is relatively small.

The invention discloses a UPLC/MS/MS detection method of the 1-hydroxymidazolam concentration in a liver microsome. The UPLC/MS/MS detection method comprises the following steps that 1, a liver microsome incubation system is established, serial concentrations of 1-hydroxymidazolam comparison products are added to prepare a standard curve sample; 2, the standard curve sample is injected into a UPLC/MS/MS liquid chromatograph/mass spectrometer for detection, and a standard 1-hydroxymidazolam curve is obtained according to the detection result; 3, a sample to be detected is prepared by adopting the same method as the step 1 and is injected into the UPLC/MS/MS liquid chromatograph/mass spectrometer, detection is performed under the same conditions as the step 2, and the 1-hydroxymidazolam concentration in the sample to be detected is obtained according to the standard curve. The UPLC/MS/MS detection method is short in analysis time, high in sensitivity and small in sample size, meets the methodological validation requirement, is suitable for determination of the 1-hydroxymidazolam concentration in the liver microsome incubation sample and has wide application prospect.

The invention discloses a method for detecting the concentration of related substances in an ibuprofen drug based on ultrahigh liquid chromatography, and belongs to the technical field of analytical chemistry. According to the detection method, the related substances in the ibuprofen medicine are determined on the basis of high performance liquid chromatography; and the related substances such asimpurities C, impurities J, impurities M and impurities ibuprofen sorbitol ester in the ibuprofen medicine are qualitatively and quantitatively detected by adopting the ultra-high performance liquid chromatography, so that the analysis time of a sample can be shortened to 1/3 of that of an HPLC analysis method; impurities with different structures are separated and detected in a short time; the UPLC is provided with a low-diffusion and low-cross-contamination automatic sample injector, and is provided with an in-needle sample injection probe and a pressure-assisted sample injection technology,so that the detection method designed by the invention is more excellent in repeatability and stability, and can effectively detect impurities.

The present invention provides stable pharmaceutical formulations comprising a human antibody that specifically binds to human angiopoietin-like protein 3 (ANGPTL3). The formulations may contain, in addition to an anti-ANGPTL3 antibody, a buffer; an organic cosolvent; at least one viscosity modifier, and optionally at least one amino acid. The pharmaceutical formulations of the present invention can be administered via intravenous infusion or subcutaneously and exhibit a substantial degree of antibody stability after storage for several months.

The invention relates to a Chinese herbal medicine component preparation for treating asthma and A preparing process and quality control method thereof. The preparation is prepared from Chinese herbal raw material medicines including Chinese holly, radix glehniae, radix salviae miltiorrhizae, licorice root, seabuckthorn, bitter almond and tabasheer. Extraction is conducted through different methods, and the capsule preparation is prepared; through reasonable compatibility and preferential preparation, the Chinese herbal raw material medicines are complementary in effect and have the effects of eliminating phlegm, relieving cough, opening the inhibited lung-energy, reliving asthma and safely and effectively treating the asthma; through the dosage form preparation process and quality control research, selectable dosage forms are increased for the compound clinical medication, and the medical value and economic value of the Chinese herbal medicine component are expected to be enlarged.

Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.