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Pharmaceutical composition having function cancer of the lungs against

A composition and anti-lung cancer technology, applied in the directions of drug combinations, anti-tumor drugs, medical preparations containing active ingredients, etc., can solve problems such as undiscovered anti-lung cancer effects, and achieve inhibiting lung metastasis, improving spleen index and thymus index. Effect

Inactive Publication Date: 2008-04-02
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But up to now, Chong Facility and Astragalus membranaceus are used alone, so there is no report on the pharmaceutical composition that has anti-lung cancer effect and consists of Chong Facility saponin extract and Astragalus polysaccharide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1. Pass 500g of the coarse powder of Dianzhonglou produced in Yunnan through a 5-mesh sieve, soak it in 4 times the volume ratio of 70% and 85% ethanol for 1 hour, and then heat and reflux at 85°C for 3 times, 2 hours each time , combine the extracts and concentrate to obtain extracts; add the extracts to 100 times the volume ratio of 20% ethanol and disperse evenly, centrifuge, dissolve after precipitation, and centrifuge again, repeat 2 times, and combine the supernatants; The above-mentioned supernatant is passed through a macroporous adsorption resin chromatography column, the amount of dry resin used is calculated according to the weight ratio of 5:1 to the extract, the column flow rate is 1-3BV / h, and the eluent is discarded; use 60%-80 % ethanol elution, the flow rate is 2 ~ 5BV / h, collect the ethanol eluate, concentrate under reduced pressure and vacuum dry to obtain 47.1g of papaya saponin extract.

[0015] 2. Dry and pulverize 300g of astragalus, add 10 times ...

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Abstract

A medicine combination has the function of resisting lung cancer. The combination is mixed with rhizoma paridis saponin and milk vetch root amylose according to the weight ratio of 3 to 1. The rhizoma paridis is extracted by alcohol and then the rhizoma paridis extract is obtained through gradient elutriation of macroporous absorption resin alcohol; the milk vetch root is extracted by water and then the protein is settled and removed to get the milk vetch root amylose; the two extracts are mixed and the medicine is made. The MTT activities experiment in vitro with the MTT method has proven that the medicine combination can obviously control the growth of various lung cancer cells such as LA795 lung adenocarcinoma cell and the IC50 can reach 26.73 ug / ml; the experiment of mouse with the lung cancer tumor has represented that the tumor constraint rate can reach 55.63 percent; in this way, lung transfer of hypodermic transplanted tumor of the mouse with the lung cancer tumor can be obviously controlled and the tumor cells can be brought to death; moreover, spleen index and thymus index can be promoted and the medicine is innocuous and has no side effect. In addition, compared with the raw materials, the medicine combination has high activity and clear function; moreover, the medicine can be made into different types.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition which has anti-lung cancer effect and is composed of pachyphyllin saponin extract and astragalus polysaccharide. Background technique [0002] The traditional Chinese medicine Zhonglou is the rhizome of Paris polyphylla Smith var. yannanensis (Paris polyphylla Smith var. yannanensis) and Paris polyphylla Smith var. It has the effect of relieving swelling and pain, cooling the liver and relieving convulsions. It is used to treat bloated, sore throat, poisonous snake bites, bruises, and convulsions caused by cold wind. Modern pharmacological studies have shown that the drug has the effects of hemostasis, expectoration, antibacterial, analgesic and sedative, anti-spermicide in early pregnancy and anti-cytotoxicity. It is clinically used in the treatment of functional uterine bleeding, neurodermatitis, surgical inflammati...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P35/00
Inventor 高文远颜璐璐满淑丽
Owner TIANJIN UNIV
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