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Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension

A technology for immune regulation and pulmonary hypertension, which can be used in drug combinations, medical preparations containing active ingredients, blood diseases, etc., and can solve problems such as vascular resistance reduction

Inactive Publication Date: 2008-04-16
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of vasodilators is controversial in patients with a sharp decrease in vascular resistance due to increased cardiac output without a decrease in pulmonary artery pressure

Method used

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  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension

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Embodiment Construction

[0032] The first aspect of the present invention includes a method of treating, controlling or preventing PH, which comprises administering to a patient in need of such treatment, prevention or control a therapeutically or preventively effective amount of an immunomodulatory compound or a pharmaceutically acceptable salt thereof, Solvates (e.g., hydrates), stereoisomers, clathrates, or prodrugs.

[0033] Unless otherwise indicated, the terms "pulmonary hypertension", "PH" and "PH and related diseases" as used herein include but are not limited to: primary pulmonary hypertension (PPH), secondary pulmonary hypertension (SPH) , Familial PPH, sporadic PPH, precapillary pulmonary hypertension, pulmonary hypertension (PAH), pulmonary hypertension, spontaneous pulmonary hypertension, thrombotic pulmonary artery disease (TPA), plexogenic pulmonary artery disease, functional I ~ Type IV pulmonary hypertension, and pulmonary hypertension related to, related to, or subordinate to the followi...

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PUM

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Abstract

Methods of treating, preventing and managing pulmonary hypertension are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate (e.g., hydrate), stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, surgery and / or lung transplantation. Specific second active agents are capable of reducing pulmonary artery pressure. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Description

1. Field of Invention [0001] The present invention relates to a method of treating, preventing and controlling pulmonary hypertension, which method comprises administering immunomodulatory compounds alone or in combination with known treatments. The invention also relates to pharmaceutical compositions and dosage regimens. Specifically, the present invention includes the use of immunomodulatory compounds in combination with surgery, transplantation therapy, and / or other standard therapies for the treatment of pulmonary hypertension. 2. Background of the invention [0002] 2.1. Pathology of PH [0003] Pulmonary hypertension ("PH") refers to a disease characterized by a continuous increase in pulmonary artery pressure. L.J. Rubin, The New England Journal of Medicine, 336(2):111, 1997. PH originates from various causes, so it is useful to classify the disease. S. Rich, Advances in Pulmonary Hypertension, 1(1): 3, 2002. The World Health Organization (WHO) divides pulmonary hypertens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/724A61K31/454A61K31/366A61K31/519A61K31/554A61K31/704
CPCA61K31/366A61K31/554A61K31/7048A61K31/454A61K31/519A61P11/00A61P25/30A61P31/18A61P33/12A61P37/02A61P7/00A61P7/02A61P9/00A61P9/04A61P9/12
Inventor 杰罗米·B·杰奥迪斯
Owner CELGENE CORP