Endoparasiticide

Abstract

The present invention relates to compositions which can be applied externally, comprising emodepside and praziquantel or epsiprantel and also 1,2-isopropylideneglycerol, to their preparation and to their use for controlling endoparasites.

Description

technical field [0001] The present invention relates to a composition for external application comprising Emodepside and praziquantel or Epsiprantel and 1,2-isopropylidene glycerol, to the preparation of this composition and to its use in the prevention and treatment of Uses by endoparasites. Background technique [0002] The anthelmintic active compound praziquantel (US P 4 001 411) and the structurally related active compound exetel (US P 4 661 489) are usually administered orally, see for example DE-A-19941 024, WO 98 / 03157, US 2002 / 0081292 A1 and WO 97 / 25976. In the case of topical application of endoparasiticides, the active compounds have to pass through the skin into the bloodstream in order to reach the endoparasites in question. Since praziquantel and exetal are not particularly suitable for transdermal administration, a topical transdermal application form is not routine for this active compound due to the difficulties anticipated. Compositions for the skin tre...

AI Technical Summary

Problems solved by technology

[0017] Although few prior art publications suggest topical administration of praziquantel or cyclic depsipeptides, it is known to those skilled in the art that these active compounds are not particularly suitable for this recommendation and as a result these known The formulations are not entirely satisfactory, especially in e.g. so-called dose-driving worms such as whipworms (Trichuris vulpis) and / or tapeworms (Taenia canis)

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