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Epsiprantel external preparation and its preparation method and use

An external preparation, the technology of escital, is applied in pharmaceutical formulations, aerosol delivery, oil/fat/wax inactive ingredients, etc., which can solve the problems of systemic effects and side effects that are difficult to apply, and achieve obvious economic and social benefits. , Solve the problem of schistosomiasis, the effect of comprehensive control is good

Inactive Publication Date: 2014-06-18
QINGDAO BOITE BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shortcomings of the above-mentioned oral preparations limit the application of Exetel. In addition, the systemic effects and side effects of the oral preparations are also difficult to apply to the situation of short-term launching, such as the treatment of static water bodies such as fish ponds, emergency treatment of temporary environments, and flood control. Emergency prevention, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 : 1% Exetal Lotion

[0022] Take 1% Exetel, 20% white mineral oil, 5% caprylic acid, 5% ozokerite, 2.5% olive oil, 1% glyceryl stearate, and make up 100% of cosmetic vaseline by mass percentage. Under stirring at a temperature of 70-80° C. and a rotating speed of 50-100 rpm, the exetel was completely dissolved to obtain a 1% exetel smear. The prepared Exetal smear is a paste, white and delicate, with moderate viscosity, good wettability after spreading, no scales, stable dosage form, no peculiar smell, after being placed at -10°C or 45°C for 48 hours , returned to room temperature, no delamination, no water, no stimulation to the human body.

Embodiment 2

[0024] Take 2% Exetel, 20% white mineral oil, 5% capric triglyceride, 5% ozokerite, 3% olive oil, 1% glyceryl stearate, and make up 100% of cosmetic vaseline by mass percentage. Under stirring at a temperature of 70-80°C and a rotation speed of 50-100 rpm, the exetel is completely dissolved to obtain a 2% exetel spread. The prepared Exetal smear is a paste, white and delicate, with moderate viscosity, good wettability after spreading, no scales, stable dosage form, no peculiar smell, after being placed at -10°C or 45°C for 48 hours , returned to room temperature, no delamination, no water, no stimulation to the human body.

Embodiment 3

[0026] Take 5% exetel, 20% white mineral oil, 5% caprylic acid, 5% ozokerite, 5% olive oil, 2% glyceryl stearate, and make up 100% of cosmetic vaseline by mass percentage. Under stirring at a temperature of 70-80° C. and a rotation speed of 50-100 rpm, the exetal was completely dissolved to obtain a 5% exetal spread. The prepared Exetal smear is a paste, white and delicate, with moderate viscosity, good wettability after spreading, no scales, stable dosage form, no peculiar smell, after being placed at -10°C or 45°C for 48 hours , returned to room temperature, no delamination, no water, no stimulation to the human body.

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PUM

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Abstract

The invention discloses an epsiprantel external preparation and its preparation method and use. The epsiprantel external preparation comprises, by mass, 1-10% of epsiprantel, 15-40% of white mineral oil, 5-10% of caprylic / capric triglyceride, 5-10% of ceresine, 2-6% of olive oil, 1-2% of glyceryl stearate and the balance Vaseline. The epsiprantel external preparation is a novel dosage form which can be directly smeared on the human skin. The epsiprantel external preparation is not emulsified and dissolved on the water surface, can adhere to the skin even if contacting with the water surface and has stable drug effects. The epsiprantel external preparation is efficient, environmentally friendly, low toxic and safe, can be used simply, can save time and labor, can produce small adverse influence on the human body and has a low comprehensive cost.

Description

technical field [0001] The invention specifically relates to a new exetel preparation for preventing cercariae infection of Schistosoma japonicum. Background technique [0002] Exetal is a pyrazine isoquinoline compound, which was used to drive away tapeworms in the early 1990s, and then it was found to have a good anti-schistosomiasis effect, and it was tried for clinical treatment of schistosomiasis in the late 1990s. Because of its convenience in oral administration, short course of treatment of 1-2 days, and high curative effect, it has been widely used since it came out. [0003] However, currently commercially available exetel preparations for the prevention and treatment of schistosomiasis are generally oral tablets, which are mainly used for treatment after infection with schistosomiasis, and cannot have a preventive effect on it, and some adverse effects may occur after oral administration of exetel tablets. Reactions, such as: ① Common side effects include dizzi...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/06A61K31/55A61K47/44A61P33/12
CPCY02A50/30
Inventor 郝智慧侯青青贾德强
Owner QINGDAO BOITE BIOPHARM
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