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A kind of external preparation of praziquantel and its preparation method and application

An external preparation, the technology of praziquantel, which is applied in the field of new praziquantel preparations, can solve the problems of restricting the application of praziquantel, systemic effects and side effects that are difficult to apply, achieve obvious economic and social benefits, and have good comprehensive prevention and treatment effects. The effect of the problem of schistosomiasis

Inactive Publication Date: 2011-12-21
梁晓天
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shortcomings of the above-mentioned oral preparations limit the application of praziquantel. In addition, the systemic effects and side effects of the oral preparations are also difficult to apply to the situation of short-term launching, such as the treatment of static water bodies such as fish ponds, emergency treatment of temporary environments, and flood fighting and rescue. prevention etc.

Method used

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  • A kind of external preparation of praziquantel and its preparation method and application
  • A kind of external preparation of praziquantel and its preparation method and application
  • A kind of external preparation of praziquantel and its preparation method and application

Examples

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Effect test

Embodiment 1

[0021] Embodiment 1: 1% praziquantel daub

[0022] Get praziquantel 1% by mass percentage, white mineral oil 20%, caprylic acid 5%, ozokerite 5%, olive oil 2.5%, glyceryl stearate 1%, make up 100% with cosmetic vaseline. The praziquantel is completely dissolved under stirring at a temperature of 70-80° C. and a rotating speed of 50-100 rpm to obtain a 1% praziquantel smear. The prepared praziquantel smear is a paste, white and delicate, with moderate viscosity, good wettability after spreading, no scales, stable dosage form, no peculiar smell, after being placed at -10°C or 45°C for 48 hours, Return to room temperature, no delamination, no water, no stimulation to the human body.

Embodiment 2

[0024] Get praziquantel 2% by mass percentage, white mineral oil 20%, capric triglyceride 5%, ozokerite 5%, olive oil 3%, glyceryl stearate 1%, make up 100% with cosmetic vaseline. Under stirring at a temperature of 70-80° C. and a rotational speed of 50-100 rpm, the praziquantel is completely dissolved to obtain a 2% praziquantel smear. The prepared praziquantel smear is a paste, white and delicate, with moderate viscosity, good wettability after spreading, no scales, stable dosage form, no peculiar smell, after being placed at -10°C or 45°C for 48 hours, Return to room temperature, no delamination, no water, no stimulation to the human body.

Embodiment 3

[0026] Get praziquantel 5% by mass percentage, white mineral oil 20%, caprylic acid 5%, ozokerite 5%, olive oil 5%, glyceryl stearate 2%, make up 100% with cosmetic vaseline. Under stirring at a temperature of 70-80° C. and a rotational speed of 50-100 rpm, the praziquantel is completely dissolved to obtain a 5% praziquantel smear. The prepared praziquantel smear is a paste, white and delicate, with moderate viscosity, good wettability after spreading, no scales, stable dosage form, no peculiar smell, after being placed at -10°C or 45°C for 48 hours, Return to room temperature, no delamination, no water, no stimulation to the human body.

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Abstract

The invention discloses a preparation for external use of praziquantel and its preparation method and application. The preparation is made of the following components in mass content: 1-10% of praziquantel, 15-40% of white mineral oil, caprylic acid / capric acid Triglyceride 5-10%, ozokerite 5-10%, olive oil 2-6%, glyceryl stearate 1-2%, petrolatum supplemented to 100%. The product of the invention is a novel dosage form that can be directly applied to human skin. It does not emulsify or dissolve on the water surface, and when the medicine touches the water surface, it still adheres to the skin, and the efficacy of the medicine will not be reduced. It has the characteristics of high efficiency, environmental protection, low toxicity, safety, very easy to use, time-saving and labor-saving, little adverse effect on human body, and low comprehensive cost.

Description

technical field [0001] The invention specifically relates to a new preparation of praziquantel for preventing the infection of cercariae of Schistosoma japonicum. Background technique [0002] Praziquantel is a pyrazinoisoquinoline compound, which was used to drive away tapeworms in the early 1970s, and then it was found to have a good anti-schistosomiasis effect, and it was tried for clinical treatment of schistosomiasis in the late 1970s. Due to the convenience of oral administration, the short course of treatment of 1 to 2 days, and high curative effect, praziquantel has been widely used since it came out. [0003] However, the currently commercially available praziquantel preparations for the prevention and treatment of schistosomiasis are generally oral tablets, which mainly treat schistosomiasis infection and cannot prevent it, and praziquantel tablets will produce some adverse reactions after oral administration. For example: ① Common side effects include dizziness, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4985A61P33/12
CPCY02A50/30
Inventor 梁晓天姚建民周蕾
Owner 梁晓天
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