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Epsiprantel transdermal preparation and use thereof

A transdermal preparation, the technology of escital, applied in the field of escital transdermal preparation, can solve the problems of low drug utilization rate, livestock pain, inconvenient administration, etc., and achieves no toxic side effects, remarkable curative effect and administration handy effect

Inactive Publication Date: 2014-06-18
QINGDAO BOITE BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the present stage, veterinary exetel preparations are still tablets and powders, which have disadvantages such as poor absorption, low drug utilization rate and large side effects, and because most livestock are ruminants, oral administration of exetel is easy to damage the stomach Colony balance
Although there have been Exetel injections with good absorption and high drug utilization, Exetal injections still have disadvantages such as inconvenient administration and easy pain to livestock.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of exetal transdermal preparation of the present invention comprises the following steps:

[0025] Heat an appropriate amount of 206 adjuvant, aqueous solution or purified water to 28°C-32°C;

[0026] Mix the preheated 206 adjuvant and Exetel, and add the preheated aqueous solution or purified water for further mixing until obtaining the Exetel transdermal preparation.

Embodiment 1

[0029] (1) Take 54ml of 206 adjuvant; prepare 38.32ml of sterilized PBS (PH8.0); heat the above solvent to 30℃±2℃;

[0030] (2) Weigh 7.68g of Exetel, pour it into a sterile beaker, and preheat to 30°C±2°C;

[0031] (3) Add the measured 54ml preheated 206 adjuvant into the beaker;

[0032] (4) Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing Exetel and 206 adjuvants;

[0033] (5) Start stirring at low speed (200-300 rpm) and gradually add 38.32 ml of preheated PBS, the flow rate of PBS is 5-10 liters / min;

[0034] (6) Accelerate to 2000 rpm and keep it for 10 minutes;

[0035] (7) Stop stirring to obtain the exetel transdermal preparation containing 8% (percentage by weight) exetel, wherein the weight percent of 206 adjuvant is 50%, and the volume percent is 54%; then the prepared The emulsion is placed at low temperature (4°C-12°C).

Embodiment 2

[0037] (1) Measure 43.2m1 of 206 adjuvant; prepare 33.6m1 of sterilized physiological saline; heat the above solvent to 30°C±2°C;

[0038] (2) Weigh 23.2g of Exetel, pour it into a sterile beaker, and preheat to 30°C±2°C

[0039] (3) Add the measured 43.2m1 preheated 206 adjuvant into the beaker;

[0040] (4) Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing Exetel and 206 adjuvants;

[0041] (5) Start stirring at a low speed (200-300 rpm) and gradually add 33.6 ml of preheated saline, the flow rate of which is 5-10 liters / min;

[0042] (6) Accelerate to 2000 rpm and keep it for 10 minutes;

[0043] (7) Stop stirring to obtain the exetel transdermal preparation containing 24% (percentage by weight) exetel, wherein the weight percentage of 206 adjuvant is 40%, and the volume percentage is 43.2%; then the prepared The emulsion is placed at low temperature (4°C-12°C).

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Abstract

The invention belongs to the technical field of veterinary drugs and discloses an epsiprantel transdermal preparation. The psiprantel transdermal preparation contains 8-35wt% of epsiprantel, 40-60wt% of a 206 adjuvant and 5-45wt% of an aqueous solution or purified water. The invention also discloses a use of the epsiprantel transdermal preparation. The epsiprantel transdermal preparation can be used conveniently. Compared with the oral preparation, the epsiprantel transdermal preparation has the same effects of treating and preventing schistosomiasis transmission.

Description

technical field [0001] The invention relates to exetel medicine for preventing and treating schistosomiasis, in particular to an exetel transdermal preparation and application thereof. Background technique [0002] Schistosomiasis is prevalent in 76 countries and regions including tropical and subtropical regions. It is a serious zoonotic parasitic disease with a worldwide distribution. The global threatened population is as high as 600 million people, and the number of infected people reaches 200 million. At least 20,000 people died of schistosomiasis. Before the clinical application of large-scale molluscicide and schistosomiasis vaccine is realized, anti-schistosomiasis drugs are still the main means of preventing and controlling schistosomiasis. At present, the drugs used to treat schistosomiasis mainly include praziquantel, exetel, artemisinin and its derivatives such as meth. Among these drugs, Exetel is recommended by WHO as the first choice drug for the treatment...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/55A61K47/26A61P33/12
Inventor 郝智慧侯青青贾德强
Owner QINGDAO BOITE BIOPHARM
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