Valid target of common peganum seed, preparing method and uses of dehydrogenization telepathine monomer

A technology of dehydrocamiprine and effective parts, which is applied to the preparation of effective parts of Camelia officinalis and dehydrocamelline monomers and the fields of their use, and can solve the problem of neglect of function characteristics, insufficient development and utilization of characteristic resources, etc. problem, to achieve the effect of low production cost, easy operation and high purity

Inactive Publication Date: 2008-07-30
XINJIANG HUASHENGYUAN MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of them focus on the research and application of anti-tumor, while the characteristics of other aspects are ignored, and they have not been fully developed and utilized as characteristic resources.

Method used

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  • Valid target of common peganum seed, preparing method and uses of dehydrogenization telepathine monomer
  • Valid target of common peganum seed, preparing method and uses of dehydrogenization telepathine monomer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, the preparation of the effective part of Camelia chinensis

[0033] Take 1000 grams of seeds of Peganum harmala L. and pulverize them to 20 meshes, first use a carbon dioxide supercritical extraction device to extract for 3 hours under the conditions of a pressure of 35Mpa, a temperature of 40°C, and a flow rate of carbon dioxide of 4.5L / h. 8000 milliliters of water, adjust the pH to 9.5 with concentrated ammonia water, extract by cold soaking twice, 24 hours each time, filter, discard the alkaline water, and extract the dregs with 7500 milliliters of 80% acidic ethanol aqueous solution (adjust the pH to 4) for three times , 2 hours each time. The extracts were combined, concentrated under reduced pressure to nearly dryness, soaked in 2200 ml of 2% hydrochloric acid for 12 hours, filtered, added concentrated ammonia water to the filtrate to adjust the pH to 9.5, stored in cold storage for 24 hours, filtered, and the residue was dried to obtain the effectiv...

Embodiment 2

[0034] Embodiment 2, the preparation of the effective part of Camelia chinensis

[0035] Take 1000 grams of Peganum harmala L. seeds and pulverize them to 10 meshes, first use a carbon dioxide supercritical extraction device to extract for 3 hours at a pressure of 15Mpa, a temperature of 35°C, and a carbon dioxide flow rate of 4.5L / h. 8000 milliliters of water, adjust the pH=9.5 with concentrated ammonia water, extract by cold immersion for 48 hours, filter, discard the alkaline water, and extract the dregs with 6000 milliliters of 90% acidic ethanol aqueous solution (adjust the pH value to 5) and extract three times with 50 kHz ultrasonic waves. 30 minutes each time. The extracts were combined, concentrated under reduced pressure to nearly dryness, soaked in 1600 ml of 1% hydrochloric acid for 8 hours, filtered, added ammonia water to the filtrate to adjust pH=10, stored in cold storage for 24 hours, filtered, and the residue was dried to obtain the effective fraction 71 gra...

Embodiment 3

[0036] Embodiment 3, the preparation of the effective part of Camelia chinensis

[0037]Take 1000 grams of seeds of Peganum harmala L. and pulverize them to 20 meshes, first use a carbon dioxide supercritical extraction device to extract for 2 hours under the conditions of a pressure of 25Mpa, a temperature of 40°C, and a flow rate of carbon dioxide of 4.5L / h. 6000 ml of water, adjust the pH to 10 with concentrated ammonia water, extract by cold immersion for 48 hours, filter, discard the alkaline water, and extract the dregs with 6500 ml of 70% acidic ethanol aqueous solution (adjust the pH to 6) at 60-80°C for 2 times , 2 hours each time. The extracts were combined, concentrated under reduced pressure to nearly dryness, soaked in 1200 ml of 2% hydrochloric acid for 24 hours, filtered, added ammonia water to the filtrate to adjust pH=10, stored in cold storage for 24 hours, filtered, and the filter residue was dried to obtain the effective fraction 60 grams, and the content ...

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Abstract

The invention relates to an effective part of seed of common peganum, a preparation method of dehydrogenized seed of common peganum alkali monomer and the usage for relieving pain or treating digestive system diseases thereof. The medicine firstly adopts carbon dioxide super interface extraction to degrease and then experiences impurities by alkaline water cold leaching and then extracts through acid alcohol solution and finally through acid dissolution, alkali precipitating, purification, decompression and drying the medicine is gotten. The essential component is dehydrogenized seed of common peganum. Through the experiment of using acetic acid to affect the mice torsion body and the experiment of using indomethacin to cause the mice get gastric ulcer show that the seed of common peganum and the dehydrogenized seed of common peganum alkali monomer have certain pain easing and anti-gastric ulcer. The invention can be used as the active component in preparing analgesic drug and drug for treating digestive system disease.

Description

technical field [0001] The present invention relates to a preparation method and application of the effective part of camel seed and dehydrohaeline monomer, specifically, the effective part of camel seed and dehydrohaeline monomer can be prepared according to the method. body, and the effective part of the prepared camel roe can be combined with pharmaceutically acceptable carriers or other suitable excipients, and can be made into internal dosage forms for oral administration and non-oral administration according to conventional methods. Injection or other dosage forms, and the obtained effective parts of the camel seed and dehydrohaeline monomer have analgesic effect and the effect of treating digestive system diseases, and can be used for preparing analgesic drugs and drugs for treating digestive system diseases. Background technique [0002] Camelia is the dry and mature seed of Peganum harmala L., a plant of the family Tribulus terrestris. It has a slight smell and a bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K31/437A61P1/00A61P25/04A61P29/00C07D471/04A61K131/00
CPCY02P20/54
Inventor 戴秀勇孙殿甲范文玺刘永斌徐建军马芹郭亮于富生
Owner XINJIANG HUASHENGYUAN MEDICINE TECH
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