Novel type radiographic contrast suitable for multi-imaging pattern
An imaging mode and contrast agent technology, applied in the field of biomedical engineering, can solve problems such as toxic and side effects limiting practical application prospects, achieve the effect of reducing application risks and economic burdens, and broadening practical application prospects
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example 1
[0029] Example 1: Preparation of porphyrin-loaded manganese microbubble contrast agent
[0030] Phosphatidylcholine (DPPC), phosphatidylethanolamine (DPPE), dipalmitoyl phospholipid acid (DPPA) were mixed with porphyrin manganese (1mg) in a mass ratio of 5:2:1, and 50 μl of poloxamer, Glycerol 0.5mg; after sealing the plastic tube with a rubber stopper, water bath at 37°C for 30min, then replacing the air in the plastic tube with perfluoropropane gas, and finally obtaining the porphyrin-loaded manganese microbubble contrast agent after mechanical shaking for 60s. (Figure 1, Figure 2, Figure 3).
example 2
[0031] Example 2: Preparation of Phthalocyanine Microbubble Contrast Agent
[0032] Phosphatidylcholine (DPPC), phosphatidylethanolamine (DPPE), dipalmitoyl phospholipid acid (DPPA) were mixed with phthalocyanine (1mg) in a mass ratio of 5:2:1, and 50 μl of poloxamer, glycerol was added. 0.5 mg; after sealing the plastic tube with a rubber stopper, water bath at 37 °C for 30 min, then replacing the air in the plastic tube with perfluoropropane gas, and finally obtaining the phthalocyanine-loaded microbubble contrast agent after mechanical shaking for 60 s.
example 3
[0033] Example 3: Enhancement effect of porphyrin-loaded manganese microbubble contrast agent on ultrasound imaging
[0034] Using GE Vivid7 color ultrasonic diagnostic instrument, 12L linear array probe, the second harmonic emission frequency is 5.2MHz, and the receiving frequency is 10.5MHz. All conditions of the instrument are set to the same standard: the mechanical index (MI) at the second harmonic is set to 0.24, the gain is -14dB, the imaging depth is fixed to 4cm, and the parameters such as TGC and focus range are adjusted to the best state. Use the internal workstation of the ultrasound system to store dynamic and static angiography data.
[0035] The New Zealand white rabbit (from the Experimental Animal Center of Chongqing Medical University) was used as the experimental object. After intramuscular injection of 4% pentobarbital sodium (1ml / kg), the New Zealand white rabbit was anesthetized and then fixed in a supine position. The sonogram of the rabbit liver sectio...
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