Novel type radiographic contrast suitable for multi-imaging pattern

An imaging mode and contrast agent technology, applied in the field of biomedical engineering, can solve problems such as toxic and side effects limiting practical application prospects, achieve the effect of reducing application risks and economic burdens, and broadening practical application prospects

Inactive Publication Date: 2008-07-30
许川山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the continuous deepening of research on acoustic contrast agents, the liquid fluorocarbon emulsion-type acoustic contrast agent obtained by changing the film-forming material and core material can significantly enhance the ultrasound and CT images of the target area; by adding Gd-DTPA Afterwards, it can also enhance the MRI image of the target area, and it is expected to develop into a new type of shared contrast agent suitable for multi-modal imaging, but its practical application prospects are severely limited due to the toxic and side effects of Gd-DTPA itself.

Method used

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  • Novel type radiographic contrast suitable for multi-imaging pattern
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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Example 1: Preparation of porphyrin-loaded manganese microbubble contrast agent

[0030] Phosphatidylcholine (DPPC), phosphatidylethanolamine (DPPE), dipalmitoyl phospholipid acid (DPPA) were mixed with porphyrin manganese (1mg) in a mass ratio of 5:2:1, and 50 μl of poloxamer, Glycerol 0.5mg; after sealing the plastic tube with a rubber stopper, water bath at 37°C for 30min, then replacing the air in the plastic tube with perfluoropropane gas, and finally obtaining the porphyrin-loaded manganese microbubble contrast agent after mechanical shaking for 60s. (Figure 1, Figure 2, Figure 3).

example 2

[0031] Example 2: Preparation of Phthalocyanine Microbubble Contrast Agent

[0032] Phosphatidylcholine (DPPC), phosphatidylethanolamine (DPPE), dipalmitoyl phospholipid acid (DPPA) were mixed with phthalocyanine (1mg) in a mass ratio of 5:2:1, and 50 μl of poloxamer, glycerol was added. 0.5 mg; after sealing the plastic tube with a rubber stopper, water bath at 37 °C for 30 min, then replacing the air in the plastic tube with perfluoropropane gas, and finally obtaining the phthalocyanine-loaded microbubble contrast agent after mechanical shaking for 60 s.

example 3

[0033] Example 3: Enhancement effect of porphyrin-loaded manganese microbubble contrast agent on ultrasound imaging

[0034] Using GE Vivid7 color ultrasonic diagnostic instrument, 12L linear array probe, the second harmonic emission frequency is 5.2MHz, and the receiving frequency is 10.5MHz. All conditions of the instrument are set to the same standard: the mechanical index (MI) at the second harmonic is set to 0.24, the gain is -14dB, the imaging depth is fixed to 4cm, and the parameters such as TGC and focus range are adjusted to the best state. Use the internal workstation of the ultrasound system to store dynamic and static angiography data.

[0035] The New Zealand white rabbit (from the Experimental Animal Center of Chongqing Medical University) was used as the experimental object. After intramuscular injection of 4% pentobarbital sodium (1ml / kg), the New Zealand white rabbit was anesthetized and then fixed in a supine position. The sonogram of the rabbit liver sectio...

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Abstract

The invention pertains to a biomedical engineering field, particularly a novel contrast agent which is suitable for a plurality of imaging models; the novel contrast agent is constructed by porphyrin and derivative(s) thereof and/or phthalocyanin and derivative(s) thereof combining with acoustic contrast agent. When in use, the novel contrast agent is systemically or partly acted on target tissue, which can intensify the effects of X ray, ultrasonic, computer X ray tomoscan (CT), magnetic resonance imaging and optical imaging for the target tissue.

Description

technical field [0001] The present invention belongs to the field of biomedical engineering, and more particularly, the present invention relates to a novel contrast agent suitable for various imaging modes. Background technique [0002] After a hundred years of medical imaging education, imaging technologies emerge in an endless stream. Of course, whether it is traditional imaging techniques such as X-ray, ultrasound, computed tomography (CT), or modern molecular imaging techniques such as magnetic resonance imaging (MRI), optical imaging, it is the foundation for the development of basic and clinical medicine. Thanks for the hard work. Since the existing imaging technologies have their own advantages and disadvantages in terms of temporal and spatial resolution, penetration depth, and energy extension, the combined application of multiple modes of imaging technology will provide more and more comprehensive information, which will provide future The development of contras...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/04A61K49/06A61K49/22
Inventor 许川山夏新蜀于廷和王志刚
Owner 许川山
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