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Method of producing polymer field-flow fractionation chip

A production method and field flow separation technology, applied in the field of biological separation, can solve problems such as unfavorable batch production and low productivity, and achieve the effects of easy online monitoring, convenient selection, and reduced production costs

Inactive Publication Date: 2008-07-30
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

This method has low productivity and is not conducive to mass production

Method used

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  • Method of producing polymer field-flow fractionation chip
  • Method of producing polymer field-flow fractionation chip

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Embodiment Construction

[0031] The specific content of the present invention will be further described below in conjunction with the embodiments shown in the accompanying drawings.

[0032] In the method, a separation flow channel is manufactured by a hot molding process, and a separation flow channel system is formed by a thermal bonding process. The method comprises: making a hot-pressing template, hot-molding the separation flow channel of the chip, and thermal bonding of the separation flow channel system of the chip.

[0033] 1. Fabrication of hot pressing template

[0034] There are three kinds of manufacturing methods of the hot pressing formwork of the present invention:

[0035] The first method: take the metal plate that is the same as the depth of the separation channel or greater than the depth of the separation channel as the blank, and the surface of the blank plate is required to be flat enough, and no protrusions or depressions are allowed on the surface. If the rough material does ...

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Abstract

The invention relates to a manufacturing method for separating chips by a polymer field-flow and belongs to a new method and a new manufacturing technology of a biology separation filed. The chip is manufactured by the polymer through the technology of hot die forging and thermal bonding. The method comprises the following processes: (1) the manufacturing of the hot die template: the template having the same outer shape size with the separating channel is cut out form the metal plate. The size refers to the data as follows: the length is 300-600mm; the width is 20-40mm; the thickness is 0.5-2mm. The upper and lower bottom surface of the template are carried out a polishing process; (2) After the complete is heated on a hot press until softening, the outer shape of the separating channel is pressed out from the plate using the processed template; (3) the covering plate is carried out a thermal bonding using the coverslip and substrate and then bands out the chip. The invention solves the problems of single-use chip in a biology separating field, a medicine screening, a food and commodity inspection as well as an environment detection analysis. Compared with the traditional technology, the invention has the advantages of simple process and low manufacturing cost, as well as providing a precondition for the continuous production.

Description

technical field [0001] The invention relates to a new polymer field flow separation chip and a manufacturing method, which belong to a new method and a new manufacturing process in the field of biological separation. Background technique [0002] Field flow fractionation (Field flow fractionation-FFF) is a new separation technology, which can be used for the separation of macromolecules, colloids and particles. The previous field flow separation is composed of a flat strip-shaped flow channel formed between upper and lower plates that are very close to each other, and the carrier liquid flows in it. The carrying current is laminar flow, its flow pattern is parabolic, and the velocity on the center line is the largest. The lateral field is applied from the side perpendicular to the flow direction, and the lateral field causes different components to be located at different positions from the lower wall, so they have different moving speeds, and the separation is carried out ...

Claims

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Application Information

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IPC IPC(8): B29C43/02
Inventor 左春柽张学军杨凯钧
Owner JILIN UNIV
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