Airway administration of activated protein C in inflammatory conditions affecting the respiratory tract
A protein, inflammatory technology, applied in the field of airway administration of activated protein C in inflammatory conditions affecting the respiratory tract, can solve problems such as reduced fibrinolytic activity
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Embodiment 1
[0141] A 60-year-old patient with severe ARDS had opacities mainly concentrated in the right lung as judged by thoracic radiography. Bronchoalveolar lavage (BAL) was performed via bronchoscope in the right lower lobe bronchi using a single dose of 5 mg of activated drotrecogin-α (Xigris) dissolved in 20 ml of normal saline. No significant side effects and airway bleeding were observed. The next day, the cloudiness cleared to some extent in the right lower lobe treated with BAL. On the other hand, as PaO 2 / FiO 2 A single dose of APC did not improve gas exchange as monitored by the ratio.
Embodiment 2
[0144]
[0145]
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