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Medicine for relieving or neutralizing the effect of alcohol and resisting intoxication and preparation method thereof

An anti-intoxication and drug technology, applied in the directions of drug combination, pharmaceutical formulation, inactive components of polymer compounds, etc., can solve problems such as poor hangover effect, and achieve the effects of shortening the sobering time, reducing the drunken rate, and delaying the drunken time.

Inactive Publication Date: 2008-10-15
SHAANXI NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to overcome the disadvantages of existing medicines with poor hangover effect, and provide a hangover medicine with clear mechanism and good hangover effect and its preparation method

Method used

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  • Medicine for relieving or neutralizing the effect of alcohol and resisting intoxication and preparation method thereof
  • Medicine for relieving or neutralizing the effect of alcohol and resisting intoxication and preparation method thereof
  • Medicine for relieving or neutralizing the effect of alcohol and resisting intoxication and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 prepares 1000 capsules of product of the present invention

[0028] The first step: the preparation method of acetic acid bacteria extract freeze-dried powder: Acetobacter pasteurianus subsp. 28-32°C, ventilation rate 1:0.2 (V / V), stop cultivation when acidity reaches 1g / L, about 60h, inoculum size is 5%, and cultivation time is about 60h. The culture medium is 95% alcohol 1%, glucose 1%, yeast extract 1%, pH=6.8.

[0029]After the cultivation in the seed tank, the culture solution was centrifuged at 10°C and 3000g for 20 minutes to collect the cells, and 5 times the amount of 0.05M phosphate buffer with pH=6.5 was added to resuspend the cells, and the cells were broken with an ultrasonic cell disruptor. Ultrasonic crushing conditions: 40kHz, 200W, temperature 30°C, processing time 5min, gap 20s, that is, 5min / 20s. After sonicating the cells, immediately freeze the bacterial solution at -20°C for 30 minutes (the thickness of the bacterial solution is not ...

Embodiment 2

[0035] Embodiment 2 prepares 1000 capsules of product of the present invention

[0036] The used raw materials and auxiliary materials and their weight proportions are as follows:

[0037] The first step: the preparation method of the acetic acid bacteria extract freeze-dried powder: the same as in Example 1.

[0038] The second step: 1000 capsules are prepared

[0039] Acetic acid bacteria extract freeze-dried powder 30g

[0040] Cornstarch 35g

[0041] Magnesium Stearate 5g

[0042] Its preparation process is carried out according to the conventional process of pharmacy capsules. After the acetic acid bacteria extract freeze-dried powder is evenly mixed with corn starch and magnesium stearate, it is packed separately, and each capsule weighs 0.07g. Each capsule contains acetic acid bacteria extract and freeze-dried. Powder 30mg.

[0043] Usage and dosage: Oral, 1-2 capsules each time, take it with warm water 10-30 hours before drinking.

Embodiment 3

[0044] Embodiment 3 prepares 1000 capsules of product of the present invention

[0045] The used raw materials and auxiliary materials and their weight proportions are as follows:

[0046] The first step: the preparation method of the acetic acid bacteria extract freeze-dried powder: the same as in Example 1.

[0047] The second step: 1000 capsules are prepared:

[0048] Acetic acid bacteria extract freeze-dried powder 30g

[0049] Dextrin 10g

[0050] Its preparation process is carried out according to the conventional process of pharmacy capsules. After the acetic acid bacteria extract freeze-dried powder is evenly mixed with dextrin, it is packed separately. Each capsule weighs 0.04g and each capsule contains 30mg of the acetic acid bacteria extract freeze-dried powder.

[0051] Usage and dosage: Oral, 1-2 capsules each time, take it with warm water 10-30 hours before drinking.

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Abstract

The invention relates to a drug for relieving hangover and a preparation method thereof. The drug is prepared from acetic acid bacteria microorganism thallus as raw material by extracting to obtain mixture containing high activity alcohol dehydrogenase and acetaldehyde dehydrogenase, optionally adding adjuvants, and making into oral capsule and granule by conventional method. The alcohol can be rapidly metabolized into acetic acid in gastrointestinal tract to be further absorbed or excreted when the drug is administered by alcohol user before drinking, thereby reducing injury of excessive alcohol to human body to have good hangover relieving effect. The drug can be also made into anti-hangover health food.

Description

technical field [0001] The invention relates to an anti-alcoholic medicine and a preparation method thereof. Background technique: [0002] Alcohol is a beverage containing ethanol. Drinking alcohol is a kind of pleasure in people's daily life and social activities. With the improvement of living standards and the increase of work competition pressure, the consumption of alcohol has increased significantly. Alcohol has complex pharmacological effects on the human body. Excessive drinking can lead to ethanol poisoning, and severe cases can cause death. A report of the World Health Organization pointed out that alcohol poisoning is the number one public hazard in the world today, and its toxic effects can affect the main organs of the whole body, especially the liver. In western countries, 80% of the causes of liver cirrhosis are caused by alcohol poisoning. Excessive drinking has a non-negligible impact on the occurrence and prognosis of fatty liver disease, viral hepatitis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K35/74A61K9/16A61K9/48A61K47/40A61P25/32
Inventor 张发荣张宝善王喆之崔浪军高渊思张谦
Owner SHAANXI NORMAL UNIV
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