Use of compound pachymic acid for preparing medicament

The technology of poiaic acid and compound is applied in the direction of drug combination, pharmaceutical formulation, medical preparation containing active ingredients, etc. It can solve the problem that there is no single compound application, and achieve the prospect of reducing the apoptosis of peripheral blood lymphocytes and improving the pharmacological effect. , strong pharmacological effect

Inactive Publication Date: 2008-11-12
刘宏宇 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The molecular formula of this compound is C 33 h 52 o 5 , white needle-like crystal, molecular weight 528, this compound can be extracted from the traditional Chinese medicine Poria cocos, and there is no application of this single compound in pharmaceuticals

Method used

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  • Use of compound pachymic acid for preparing medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Use 150kg of white poria cocos powder, soak in ether three times, each time for 48 hours, filter, take the cold extract, recover the ether under reduced pressure to obtain a light yellow extract (150g), pass through Si-gel C.C.CHCl 3 : MeOH (50:1-20:1) treatment, Fr.1, Fr.2, Fr.3 (20g), Fr.4 and Fr.5, five substances were obtained, Fr.3 (20g) was taken again Si-gel C.C.CHCl 3 :MeOH (50:1) treatment, get Fr.3.1, Fr.3.2 (15g) and Fr.3.3 three substances, take Fr.3.2 (15g) and give ODS C.C.MeOH:H 2 O (85:15) treatment, Fr.3.2.1, Fr.3.2.2, Fr.3.2.3 (8g) Fr.3.2.4 and Fr.3.2.5 five substances, take Fr.3.2.3 (8g) Repeated recrystallization of methanol, compound pachynic acid-white crystals (1500mg). Mix it with olive oil to form a mixture with a concentration of 100mg / ml, sterilize it, and seal it to make a product.

Embodiment 2

[0027] The compound pachynic acid-white crystal obtained in Example 1 was mixed with olive oil to form a mixture with a concentration of 10 mg / ml, sterilized, and sealed to make a product.

Embodiment 3

[0029] Compound pachymic acid-white crystal 200mg obtained in Example 1 is made into capsules according to a known method to become a product.

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PUM

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Abstract

The invention relates to use of compound pachymic acid in the pharmaceutical field. The product has the functions of decreasing the rejection reaction of a receptor to a graft after a transplant operation, protecting the stability of haemolymph cell mitochondrial membrane potential at the periphery of the receptor, reducing the apoptosis percentage of haemolymph cells at the periphery, stabilizing the quantity percentage of CD8 + lymph cells at the periphery, and reducing the apoptosis percentage of the haemolymph cells at the periphery and regulating the quantity percentage of CD4 + and CD8 + lymph cells under nontransplant conditions and so on, is used to reduce graft rejection reactions as well as regulate and stabilize the quantity, the proportion and the function of the lymph cells of organisms during the transplant of organs, tissues and cells of animals and human beings and so on.

Description

Technical field: [0001] The present invention relates to the application of the compound pachynic acid (3β acetoxyl 16α hydroxy lanoster 8,24(31) diene 21 acid), especially the application in the field of pharmacy. Background technique: [0002] The structural formula of the compound pachynic acid is [0003] [0004] The molecular formula of this compound is C 33 h 52 o 5 , white needle-like crystal, molecular weight 528, this compound can be prepared by extracting from the traditional Chinese medicine Poria cocos, and there is no application of this single compound in pharmaceuticals at present. Contents of the invention [0005] The purpose of the present invention is to provide a new application of the compound pachynic acid, that is, a new application in pharmacy. [0006] In fact, this project involves the application of compound pachymic acid as a medicine for treating or preventing rejection after transplantation. [0007] The invention relates to the appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P7/00A61P37/06
Inventor 刘宏宇张学峰张帆
Owner 刘宏宇
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