Trioxane dimers having high anticancer and long-lasting antimalarial activities

A compound and solvate technology, applied in the field of trioxane dimer with high anticancer activity and long-acting antimalarial activity, can solve the problem of not having long-acting antimalarial activity and the like
CN101325874AInactive Publication Date: 2008-12-17THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Publication Date
2008-12-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer and / or malaria using these compounds and compositions.
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Description

[0001] Statement of Rights Concerning Inventions Made Under Federally Sponsored Research and Development

[0002] This study was supported in part by internal research programs of the National Institute of Health (NIH, grant numbers AI34885 and RR00052), the National Cancer Institute, and the Center for Cancer Research.

[0003] Cross References to Related Applications

[0004] This application claims priority to U.S. Provisional Patent Applications Serial Nos. 60 / 748,548, filed December 8, 2005; 60 / 765,125, filed February 3, 2006; and 60 / 794,811, filed April 25, 2006, all applications Title: "Trioxane Dimers Having Surprisingly High Anticancer Activities and Surprisingly Long-Lasting Antimalarial Activities". Priority is claimed here on all of these filing dates, and the contents of each of these applications are hereby incorporated by reference as if fully set forth. field of invention

[0005] The present invention provides novel trioxane dimers, methods for their prepara...

Claims

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