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Medicine composition for injecting triamcinolone acetonide palmitate lipid microsphere and preparation method thereof

A technology of palmitate and lipid microspheres, applied in the field of medicine, can solve the problems of drug precipitation, pain, human toxicity, etc.

Inactive Publication Date: 2008-12-31
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triamcinolone acetonide palmitate is triamcinolone acetonide-21-palmitate, which has little solubility in water, but is highly fat-soluble, but has slightly less solubility in common vegetable oils. If you choose common vegetable oils, triamcinolone acetonide When palmitate is made into a pharmaceutical composition for lipid microsphere injection, there may be problems such as drug precipitation during dilution, pain at the injection site or phlebitis, and toxicity of additives to the human body.

Method used

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  • Medicine composition for injecting triamcinolone acetonide palmitate lipid microsphere and preparation method thereof
  • Medicine composition for injecting triamcinolone acetonide palmitate lipid microsphere and preparation method thereof
  • Medicine composition for injecting triamcinolone acetonide palmitate lipid microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] The composition and preparation process of each component in the pharmaceutical composition for injection of triamcinolone palmitate lipid microspheres per 100ml

[0131] composition:

[0132] Triamcinolone Palmitate 10%

[0133] Soybean Oil 25%

[0134] Medium Chain Fatty Acid Triglycerides 15%

[0135] Soy Lecithin 6.4%

[0136] Tween-80 0.8%

[0137] F68 1.0%

[0138] Glycerin 6.5%

[0139] EDTA0.5%

[0140] Sodium Oleate 0.1%

[0141] Appropriate amount of pH adjuster

[0142] The rest is water for injection.

[0143] Preparation:

[0144] (1) Mix the prescribed amount of glycerin, Tween-80, F68, EDTA, sodium oleate with water for injection preheated to 80°C, and stir until the ingredients are dissolved to obtain the aqueous phase;

[0145] (2) adding the prescribed amount of soybean lecithin and triamcinolone acetonide palmitate to the oily medium of soybean oil and medium-chain fatty acid triglycerides and mixing, heating to 80° C., and magnetically sti...

Embodiment 2

[0151] The composition and preparation process of each component in the pharmaceutical composition for injection of triamcinolone palmitate lipid microspheres per 100ml

[0152] Triamcinolone Acetonide Palmitate 0.01%

[0153] Soybean Oil 2.0%

[0154] Medium Chain Fatty Acid Triglycerides 1.5%

[0155] Soy Lecithin 0.5%

[0156] Tween-80 0.05%

[0157] F68 0.05%

[0158] Glycerin 2.25%

[0159] EDTA0.02%

[0160] Sodium Oleate 0.01%

[0161] Appropriate amount of pH adjuster

[0162] The rest is water for injection.

[0163] Preparation:

[0164] Use the components and their dosages of this example to prepare according to the same preparation method as in Example 1.

Embodiment 3

[0166] The composition and preparation process of each component in the pharmaceutical composition for injection of triamcinolone palmitate lipid microspheres per 100ml

[0167] Triamcinolone Acetonide Palmitate 0.2%

[0168] Soybean Oil 7.5%

[0169] Medium Chain Fatty Acid Triglycerides 5.0%

[0170] Soy Lecithin 3.5%

[0171] Tween-80 0.8%

[0172] F68 0.6%

[0173] Glycerin 0.5%

[0174] Sodium Oleate 0.06%

[0175] Appropriate amount of pH adjuster

[0176] The rest is water for injection.

[0177] Preparation:

[0178] The components and their dosages of this example were used to prepare according to the same preparation method as that of Formulation Example 1.

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Abstract

The present invention relates to the medical technical field, in particular to a lipid microsphere injection medical combination containing triamcinolone palmitate and a preparation method thereof.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for lipid microsphere injection containing triamcinolone acetonide palmitate and a preparation method thereof. Background technique [0002] Triamcinolone acetonide is a long-acting glucocorticoid drug with strong and long-lasting anti-inflammatory and anti-allergic effects. It is mainly used to treat various skin diseases, immune diseases, bronchial asthma, frozen shoulder, tenosynovitis, acute sprains, chronic low back pain and eye diseases, etc. Because of its remarkable curative effect, the scope of clinical application continues to expand. At present, the formulations of triamcinolone acetonide that have been listed include triamcinolone acetonide aerosol, triamcinolone acetonide oral ointment, triamcinolone acetonide gel, triamcinolone acetonide econazole cream, although such external dosage forms have strong Inflammation effect, but long-ter...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/58A61P29/00A61P37/08
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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