Solanum nigrum extract, preparation method and use thereof

A technology of extract and nightshade, applied in the field of nightshade extract, its preparation and its pharmaceutical application, can solve the problems of inability to meet high-efficiency pharmaceutical compositions, low content of active ingredients, restricted use, etc., and achieves strong production practicability, The effect of high content of active ingredients and less environmental pollution

Active Publication Date: 2012-04-25
上海硕方医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The currently used Solanum nigrum extraction method has high cost, low active ingredient content, more impurities, and relatively large pollution during the preparation process
The content of the active ingredients of the product obtained after extraction limits its use in pharmaceutical compositions, and cannot meet the needs of high-efficiency pharmaceutical compositions

Method used

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  • Solanum nigrum extract, preparation method and use thereof
  • Solanum nigrum extract, preparation method and use thereof
  • Solanum nigrum extract, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of nightshade extract:

[0043] (1) 400g of Solanum nigrum, add 2000ml of 90% ethanol, and reflux extraction 3 times, each time for 1.5 hours;

[0044] (2) Recover ethanol from the extract until there is no alcohol smell, and obtain about 300ml of concentrated solution, extract with petroleum ether 3 times, and each time the dosage is 300ml;

[0045] (3) The concentrated solution is processed into a H+ type HD-8 strong-acid cation exchange resin (Shanghai Huazhen Science and Technology Co., Ltd.) with 400ml for column adsorption, followed by water elution until the effluent is nearly colorless, 40% ethanol 400ml elution, 800ml of 90% ethanol for elution, ethanol containing ammonia (90% ethanol: 25% ammonia is 10:1) 1200ml for elution;

[0046] (4) collect the eluted part containing ammonia water ethanol, reclaim ethanol;

[0047] (5) Centrifuge the concentrated solution at 5000rpm for 10 minutes, discard the supernatant;

[0048](6) The precipitate was wa...

Embodiment 2

[0051] Preparation of nightshade extract:

[0052] (1) Solanum nigrum fruit 1000g, add 90% ethanol 5000ml, reflux extraction 3 times, each 1.5 hours;

[0053] (2) The extract is recovered from ethanol until there is no alcohol smell, and about 800ml of concentrated solution is obtained;

[0054] (3) The concentrated solution is processed into a H+ type HD-8 strong-acid cation exchange resin (Shanghai Huazhen Technology Co., Ltd.) with 1000ml for column adsorption, followed by water elution until the effluent is nearly colorless, 40% ethanol 1000ml elution, 90% ethanol 2000ml elution, ethanol containing ammonia (90% ethanol: 25% ammonia water is 10:1) 3000ml elution;

[0055] (4) collect the eluted part containing ammonia water ethanol, reclaim ethanol;

[0056] (5) Centrifuge the concentrated solution at 5000rpm for 10 minutes, discard the supernatant;

[0057] (6) The precipitate was washed with a small amount of water, centrifuged at 5000 rpm for 10 minutes, washed twice ...

Embodiment 3

[0060] Preparation of nightshade extract:

[0061] (1) 400g of Solanum nigrum, add 2000ml of 90% ethanol, and ultrasonically extract 3 times, each time for 1.5 hours;

[0062] (2) Recover ethanol from the extract until there is no alcohol smell, and obtain about 300ml of concentrated solution, extract with petroleum ether 3 times, and each time the dosage is 300ml;

[0063] (3) The concentrated solution is processed into a H+ type HD-8 strong-acid cation exchange resin (Shanghai Huazhen Science and Technology Co., Ltd.) with 400ml for column adsorption, followed by water elution until the effluent is nearly colorless, 40% ethanol 400ml elution, 800ml of 90% ethanol for elution, 1200ml of 80% ethanol containing 0.1% sodium hydroxide;

[0064] (4) collect the ethanol elution part containing sodium hydroxide, reclaim ethanol;

[0065] (5) Centrifuge the concentrated solution at 5000rpm for 10 minutes, discard the supernatant;

[0066] (6) Wash the precipitate with a small amou...

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Abstract

The invention relates to a solanum nigrum extractive, the preparation method and the medicament application thereof, wherein, the total content of solancarpine, solamargine and solasurine is 80wt% to 99wt%; the content of solancarpine is 30wt% to 50wt%; the content of solamargine is 10wt% to 30wt%; and the content of solasurine is 30wt% to 50wt%. The invention further relates to the preparation method of the solanum nigrum extractive and the application with the solanum nigrum extractive being the active components in the medicaments for preventing and curing diseases, such as tumor, diabetes, asthma, coronary heart disease, etc.

Description

technical field [0001] The present invention relates to plant Solanum nigrum extract, its preparation method, and its application as an active ingredient to prepare medicines for preventing and treating tumors, diabetes, asthma, coronary heart disease and other diseases. Background technique [0002] Solalum Nigrum L. is an annual herbaceous plant of the genus Solanum, which grows in most provinces and regions in China. The whole herb is used for medicine, cold in nature, bitter, pungent and slightly sweet, slightly poisonous, and returns to the lung and bladder meridian. Can dissipate blood stasis and reduce swelling, clear away heat and detoxify. It has a strong antibacterial effect on Staphylococcus aureus, typhoid bacillus, Shigella, Proteus, Escherichia coli, aeruginosa, and cholerae suis, and has the effect of inhibiting cancer cells, urinary system infections and leucorrhea, and is commonly used to treat carbuncles , tumors, dysentery, etc., the folks have a signifi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J39/04B01J39/00A61K36/81A61K31/58A61P3/10A61P9/10A61P11/06A61P35/00A61K131/00
Inventor 王妍秦继红
Owner 上海硕方医药科技有限公司
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