Method for treating a movement disorder

A technology of drugs and botulinum toxin, which can be used in pharmaceutical formulations, resistance to vector-borne diseases, medical preparations containing active ingredients, etc., and can solve safety problems and other issues

Inactive Publication Date: 2011-10-05
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Increased doses may have safety concerns

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Intracranial target tissue localization and methodology

[0125] Targeted methods can be used for precise intracranial administration of neurotoxins in aqueous form or in the form of implants to desired target tissues. Thus, intracranial administration of neurotoxins can be performed to treat drug-resistant tremor (i.e., resting tremor, such as may occur in Parkinson's disease, or action tremor, such as essential tremor), multiple sclerosis Tremor, post-traumatic tremor, post-hemiplegic tremor (post-stroke spasticity), tremor associated with neuropathy, writer's tremor, and epilepsy.

[0126] An initial MRI scan of the patient can be performed to obtain the length of the anterior commissure-posterior commissure and its orientation of the exoskeletal landmarks. The base of the stent can then be aligned with the plane of the anterior-posterior commissure line. CT is used for guidance and can be supplemented by ventriculography. The posterior commissure can be visuall...

Embodiment 2

[0132] Treating Parkinson's Disease with Botox Type A

[0133] A 64-year-old right-handed man presented with marked extremity tremors, bradykinesia, rigidity, and postural changes that resulted in frequent falls. A prominent twiddle-ball tremor was prominent on his right hand. Stroke was ruled out, and it was noteworthy that her symptoms worsened on the right side. A Parkinson's disease diagnosis is made. Using a CAT scan or MRI-assisted orientation, 2 units of botulinum toxin type A (e.g. or about 8 units ) into the left side of the globus pallidus. The patient was drained for 48 hours and over several (1-7) days enjoyed a marked improvement in the motor symptoms of Parkinson's patients, the improvement being more pronounced on the right side as well as the left side. His dyskinesias almost completely disappeared. The ataxia symptoms of Parkinson's disease remain in significant remission for about 2 to about 6 months. To prolong the relief of treatment, one or more...

Embodiment 3

[0135] Treating Parkinson's Disease with Botox Type B

[0136] A 68-year-old left-handed man presented with marked extremity tremors, bradykinesia, rigidity, and postural changes that resulted in frequent falls. A prominent twiddle-ball tremor was prominent on his right hand. Stroke was ruled out and notable was a worsening of symptoms on the left side. A Parkinson's disease diagnosis is made. As described in Example 1 above, 10 to about 50 units of botulinum toxin type B (e.g. or Innervate TM) into the right side of the globus pallidus. The patient was drained for 48 hours and over several (1-7) days enjoyed a marked improvement in the motor symptoms of Parkinson's disease patients, which was more pronounced on the left side as well as on the right side. His dyskinesias almost completely disappeared. The ataxia symptoms of Parkinson's disease remain in significant remission for about 2 to about 6 months. To prolong the relief of treatment, one or more polymeric impl...

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Abstract

Methods for treating a movement disorder by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A.

Description

[0001] This application is a divisional application of the patent application with the application number 01814079.3 and the title of the invention "a method for treating movement disorders". Background technique [0002] The present invention relates to methods of treating movement disorders. In particular, the invention relates to methods of treating movement disorders by intracranial administration of neurotoxins. [0003] movement disorder [0004] Movement disorders are neurological disorders involving one or more muscles or groups of muscles. Movement disorders include Parkinson's syndrome, Huntington's disease, progressive supranuclear palsy, Wilson's disease, Tourette's syndrome, epilepsy, and various chronic tremors, convulsions, and dystonias. Various clinical observations suggest that movement disorders can be attributed to abnormalities in the same or similar brain regions. For example, malfunctions in the brain's basal ganglia, a bundle of nerve cells deep at ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61P25/08A61P25/14A61P25/16A61P21/02A61K45/00A61K38/00A61K38/12A61P25/00A61P43/00
CPCA61K38/00A61K38/4893Y10S514/963Y10S514/937A61P21/00A61P21/02A61P25/00A61P25/02A61P25/08A61P25/14A61P25/16A61P43/00Y02A50/30A61K39/08
Inventor S·多诺万
Owner ALLERGAN INC
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