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Medicine for treating the coronary heart disease and preparation method thereof

A coronary heart disease and drug technology, applied in the field of drugs for the treatment of coronary heart disease and its preparation, can solve the problems of simple and rough preparation process, insufficient compatibility, and inability to use for a long time, so as to promote the regeneration of myocardial capillaries, reduce the degree of ventricular dilatation, The effect of improving insulin resistance

Inactive Publication Date: 2009-03-18
李浪辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing medicines have severe side effects and cannot be used for a long time; their compatibility is not precise enough, the preparation process is simple and rough, the disintegration time is too long, and the dissolved matter is small, so the drug effect cannot be fully exerted.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Take the medicinal materials of the following weights:

[0022] Panax notoginseng 2.6 kg, red spoon 42.5 kg, bergamot 25.3 kg, Alisma 25.3 kg, licorice 4.3 kg;

[0023] (2) Superfinely pulverize the Radix Notoginseng and Radix Glycyrrhiza in the above-mentioned (1) for subsequent use;

[0024] (3) Add 8 times the amount of water to Chishao and Alisma in the above (1), decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06 (65°C -75℃) clear paste, put it cold for later use;

[0025] (4) Add 1 times the amount of 90% ethanol to the clear paste in (3), let it stand for 24 hours, filter, recover the ethanol from the filtrate, and concentrate it to a thick paste with a relative density of 1.30 (65°C-75°C). The ointment is reserved, and the sediment is discarded;

[0026] (5) Grind the bergamot in (1) into a coarse powder, add 6 times the amount of ethanol with a purity of 90%, heat and reflux twice,...

Embodiment 2

[0029] (1) Take the medicinal materials of the following weights:

[0030] Panax notoginseng 2.5kg, red spoon 35kg, bergamot 30kg, Alisma 30kg, licorice 2.5kg;

[0031] (2) Superfinely pulverize the Radix Notoginseng and Radix Glycyrrhiza in the above-mentioned (1) for subsequent use;

[0032] (3) Add 8 times the amount of water to Chishao and Alisma in the above (1), decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06 (65°C -75℃) clear paste, put it cold for later use;

[0033] (4) Add 1 times the amount of 90% ethanol to the clear paste in (3), let it stand for 24 hours, filter, recover the ethanol from the filtrate, and concentrate it to a thick paste with a relative density of 1.30 (65°C-75°C). The ointment is reserved, and the sediment is discarded;

[0034] (5) Grind the bergamot in (1) into a coarse powder, add 6 times the amount of ethanol with a purity of 90%, heat and reflux twice, each time ...

Embodiment 3

[0037] (1) get the medicinal material of following percentage by weight:

[0038] Panax notoginseng 5kg, red spoon 55kg, bergamot 19kg, Alisma 19kg, licorice 2kg;

[0039] (2) Superfinely pulverize the Radix Notoginseng and Radix Glycyrrhiza in the above-mentioned (1) for subsequent use;

[0040] (3) Add 8 times the amount of water to Chishao and Alisma in the above (1), decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06 (65°C -75℃) clear paste, put it cold for later use;

[0041] (4) Add 1 times the amount of 90% ethanol to the clear paste in (3), let it stand for 24 hours, filter, and recover the ethanol from the filtrate, and concentrate it to a relative density of 1.30 (65°C-75°C) The thick paste is used for later use, and the sediment is discarded;

[0042] (5) Grind the bergamot in (1) into a coarse powder, add 6 times the amount of ethanol with a purity of 90%, heat and reflux twice, each time ...

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Abstract

The invention relates to a drug which is used for treating coronary heart disease, has the functions of activating blood circulation to dissipate blood stasis and regulating qi to alleviate pain, and is applicable to dilating coronary vessel and increasing blood flow. The drug is characterized by being made from active components such as notoginseng, red peony root, finger citron, alisma orientale, licorice and the like by finish processing, and realizes 'multi-target treatment' during the treatment process due to reasonable purification while keeping the original active components to not be changed; the drug can promote regeneration of the capillary vessel in myocardium, increase the blood flow of coronary artery branch or collateral circulation, and restore blood supply of the myocardium; the drug has the functions of lowering cholesterol, triglyceride and low-density lipoprotein and increasing high density lipoprotein, and can adjust lipid metabolism, slow down occurrence and development of the coronary heart disease according to important causes of the coronary heart disease (hyperlipemia, abnormal metabolism of the lipid and the like); and the drug further has effects on reducing ventricular dilatation degree, inhibiting left ventricular remodeling after myocardial infarction, improving serum insulin level and improving insulin resistance and the like.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to a medicine for treating coronary heart disease which has the functions of promoting blood circulation, removing blood stasis, regulating qi and relieving pain, and is suitable for dilating coronary vessels and increasing blood flow, and a preparation method thereof. Background technique: [0002] Capsules are a pharmaceutical dosage form. According to the relevant laws and regulations on drug management in my country, changing the dosage form is managed as a new drug research. The original dosage form of this product is tablet, which has been included in the standard issued by the Ministry of Pharmaceuticals. [0003] The age of onset of coronary heart disease (heart disease) tends to be younger. Now the proportion of young people under the age of 35 suffering from coronary heart disease is on the rise, and the youngest patient is only 20 years old. Because there ...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P9/10
Inventor 李浪辉
Owner 李浪辉
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