Proanthocyanidin effervescent tablet and preparation method thereof

A technology of proanthocyanidins and a production method, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of easy oxidative polymerization or degradation, and reduced biological activity of proanthocyanidins, so as to improve functionality and facilitate portability , the effect of high concentration

Inactive Publication Date: 2009-04-08
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN 1274547A reports that anti-aging health food effervescent tablets and its preparation method contain grape seed proanthocyanidins in its formula, and proanthocyanidins are directly exposed to the air during the production process of effervescent tablets, which are very easy to oxidize, polymerize or degrade. Lead to greatly reduce the biological activity of proanthocyanidins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A proanthocyanidin effervescent tablet and a preparation method thereof, comprising the following components in the following weight percentages:

[0032] Lotus pod proanthocyanidins: 10%

[0033] Vitamin C: 7%

[0034] Beta-cyclodextrin: 30%

[0035] Citric acid: 20%

[0036] Sodium bicarbonate: 30%

[0037] Sweetener: 1%

[0038] Fragrance: 1.5%

[0039] Magnesium Stearate: 0.1%

[0040] The lotus pod proanthocyanidin effervescent tablet prepared according to the above formula has a weight of 0.8 grams per tablet, a hardness of more than 4 kilograms, and a disintegration time of 1 minute. After being placed for 12 days, the protection rate of β-cyclodextrin to proanthocyanidins was 85.6%, and the ability to scavenge DPPH free radicals was 54 percentage points higher than that of the control group; the protection rate was 62.8% after being placed at 80°C for 1 day.

Embodiment 2

[0042] A proanthocyanidin effervescent tablet and a preparation method thereof, comprising the following components in the following weight percentages:

[0043] Proanthocyanidins from lotus seed husk: 9%

[0044] Vitamin C: 4%

[0045] Beta-cyclodextrin: 24%

[0046] Citric acid: 25%

[0047] Sodium bicarbonate: 35%

[0048] Sweetener: 0.5%

[0049] Fragrance: 2%

[0050] Magnesium Stearate: 0.1%

[0051] The lotus seed shell proanthocyanidin effervescent tablet prepared according to the above formula has a hardness of more than 4 kg and a disintegration time of 50 seconds. Each tablet is 0.8 g. After being placed for 12 days, the protection rate of β-cyclodextrin to proanthocyanidins was 83.7%, and the ability to scavenge DPPH free radicals was 59 percentage points higher than that of the control group; the protection rate was 60.4% after being placed at 80°C for 1 day.

Embodiment 3

[0053] A proanthocyanidin effervescent tablet and a preparation method thereof, comprising the following components in the following weight percentages:

[0054] Grape Seed Proanthocyanidins: 6%

[0055] Vitamin C: 8%

[0056] Beta-cyclodextrin: 24%

[0057] Citric acid: 28%

[0058] Sodium bicarbonate: 32%

[0059] Sweetener: 1%

[0060] Flavor: 0.5%

[0061] Magnesium Stearate: 0.1%

[0062] The grape seed proanthocyanidins effervescent tablet prepared according to the above formula has a hardness of more than 4 kilograms and a disintegration time of 1 minute and 12 seconds. Each tablet is 0.8 grams. After being placed for 12 days, the protection rate of β-cyclodextrin to proanthocyanidins was 92.4%, and the ability to scavenge DPPH free radicals was 63 percentage points higher than that of the control group; the protection rate was 69.1% after being placed at 80°C for 1 day.

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PUM

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Abstract

The invention relates to a proanthocyanidin effervescent tablet and a method for preparing the same. The effervescent tablet consists of the following components in the following weight percentage: 2 to 15 percent of proanthocyanidin, 1 to 10 percent of vitamin C, 10 to 40 percent of beta-cyclodextrin, 20 to 50 percent of citric acid, 30 to 35 percent of sodium bicarbonate, 0.5 to 1 percent of protein sugar, 0.1 to 2 percent of flavoring essence, and 0.05 to 0.1 percent of magnesium stearate. The proanthocyanidin effervescent tablet has the advantages that the proanthocyanidin effervescent tablet can be conveniently carried around, used and absorbed as the common effervescent tablets, and simultaneously has characteristics of high concentration of functional substances and strong functionality, as well as bright color of the proanthocyanidin; the proanthocyanidin effervescent tablet has the greatest advantage that the stability of the proanthocyanidin is greatly improved after the proanthocyanidin is embedded by the beta-cyclodextrin; the vitamin C is added in the effervescent tablet to further prevent the proanthocyanidin from being oxidized and act synergistic effect on the antioxidant activity of the proanthocyanidin so as to improve the functionality thereof; furthermore, the proanthocyanidin effervescent tablet has simple formulation, easy preparation, and low cost.

Description

technical field [0001] The invention relates to a proanthocyanidin preparation method, in particular to a proanthocyanidin effervescent tablet. Background technique [0002] Proanthocyanidins is a general term for a large class of phenolic polymers that are connected by different numbers of catechins and epicatechins at C4-C6 or C4-C8. According to the size of the degree of polymerization, two to tetramers are usually called oligomeric procyanidins (OPC for short), and those above pentamers are called polymeric procyanidins (PPC for short). Among them, oligomeric proanthocyanidins have a variety of biological activities, such as scavenging free radicals and anti-oxidation, protecting the cardiovascular system, anti-aging, anti-cancer and anti-mutation, etc., and are related to more than 80 diseases caused by free radicals, and their health care functions are significant. The oligomeric proanthocyanidins of the present invention are obtained from lotus plants (lotus leaves, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/352A61K47/40A61P39/06
Inventor 段玉清徐菲菲张海晖李金凤周密梁凯
Owner JIANGSU UNIV
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