Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A solvate, pharmaceutical technology for use in the field of cannabinoid receptor modulators
Inactive Publication Date: 2009-04-08
SCHERING AG
View PDF64 Cites 4 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0003] However, there remains a need for improved cannabinoid agents with fewer side effects and improved efficacy, especially cannabinoid receptor modulators (e.g., CB 1 receptor antagonists or inverse agonists)
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment
[0854] Preparation of bis(hetero)aryl-isoindol-1-ones
[0855] General process A:
[0856]
[0857] Diaryl-isoindol-1-ones, diheteroaryl-isoindol-1-ones and aryl-heteroaryl-isoindol-1-ones of formula (I) can be prepared by various methods , for example, condensing an aryl or heteroaryl substituted dienoic acid or acid chloride with an aryl or heteroaryl substituted unsaturated amine to form a trienamide, or making a diaryl, diheteroaryl or aryl -Condensation of a heteroaryl-substituted dienoic acid or acid chloride with an unsaturated amine followed by cyclization of the resulting trienamide by an intramolecular Diels-Alder reaction to yield a di(hetero)aryl-tetrahydro-isoindole- 1-Kones, which can be further modified as desired (eg, by reduction or alkylation, etc.).
[0858] Aldehyde a can be reacted with crotyl phosphonate to provide ester b which, after saponification, can be reacted with oxalyl chloride to give acid chloride c. Sonagashira coupling of aryl or hetero...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
A compound having the general structure of Formula (I): Chemical formula should be inserted here as it appears on the abstract in paper form. or a pharmaceutically acceptable salt, solvate, or ester thereof, is useful in treating diseases, disorders, or conditions such as obesity, metabolic disorders, addiction, diseases of the central nervous system, cardiovascular disorders, respiratory disorders, and gastrointestinal disorders.
Description
field of invention [0001] The present invention relates to cannabinoid receptor modulators (especially CB 1 receptor antagonists or inverse agonists), pharmaceutical compositions comprising such compounds, and the use of said compounds and compositions for the treatment of, for example, obesity, metabolic disorders, addiction, central nervous system diseases, cardiovascular diseases, respiratory diseases and gastrointestinal disorders. Background of the invention [0002] CB 1 The receptor is one of the most abundant neuromodulatory receptors in the brain and is expressed at high levels in the hippocampus, cortex, cerebellum and basal ganglia (eg, Wilson et al., Science, 2002, vol. 296, 678-682). Selective CB 1 Receptor antagonists, such as pyrazole derivatives, such as rimonabant (e.g. U.S. Patent 6,432,984), are useful in the treatment of various conditions, such as obesity and metabolic syndrome (e.g. Bensaid et al., Molecular Pharmacology, 2003 vol.63 , no.4, pp.908-...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more