Artificial blood vessel bracket and preparation method thereof

A technology of artificial blood vessels and vascular stents, which is applied in the field of artificial vascular stents and its preparation, can solve the problems that drug stents do not improve the survival rate and death of patients, and achieve the effects of low price, reduced manufacturing costs, and easy industrialization

Active Publication Date: 2009-04-15
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Compared with the bare stent, although the existing drug stent has made great progress in the treatment of vascular restenosis, the analysis of clinical results for many years found that the drug stent did not improve the survival rate of patients, and the drug coating may produce some Adverse effects, such as delayed thrombosis and chronic inflammatory response to bioinert polymers that can lead to patient death

Method used

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  • Artificial blood vessel bracket and preparation method thereof
  • Artificial blood vessel bracket and preparation method thereof
  • Artificial blood vessel bracket and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Add 5g silk into 200ml, 2% sodium carbonate aqueous solution, treat at 98°C for 60min, repeat 3 times, dissolve with 50% lithium bromide aqueous solution after drying, and then filter the above solution with multi-layer non-woven fabric to remove impurities, and then repack Put it into a dialysis bag and dialyze with running water for three days to obtain a 1.5% silk protein solution. The body of the stainless steel vascular stent is washed with acetone and pure water respectively, dried in the air, and then the fibroin solution is evenly sprayed on the body of the stent. The coated stents were placed in a vacuum oven and dried at 37°C for 24 hours. Put the coated stent in analytically pure ethylene glycol, treat it for 72 hours, wash it with distilled water, and then dry the coated stent in a vacuum drying oven at 37°C for 24 hours, and the dense bottom layer formed by silk protein can be attached to the vascular stent body .

Embodiment 2

[0046] Prepare 100 ml of 20% silk protein aqueous solution, then add 100 ml of 10% gelatin aqueous solution, mix evenly, refrigerate and centrifuge at high speed, and collect the supernatant. Immerse the stainless steel stent body in the above mixed solution, dry it at 20°C for 20 hours after dipping, repeat the above steps until the coating weight reaches 1000ug, so as to form a uniform coating on the surface of the stent body, and then apply the coating The stent was treated in 25% glycerol aqueous solution for 1 hour. Wash the stent with water, put the coated stent in a vacuum oven, and dry it under vacuum at 60° C. for 12 hours. Then place the coated stent in pure water, boil for 2 hours, repeat 3 times until the gelatin in the coating is completely dissolved, wash with water, and dry to obtain a vascular stent with uniform pores in the coating, adjust the ratio of silk and gelatin , vascular stents with different porosity in the coating can be obtained.

Embodiment 3

[0048] Prepare 5% silk protein aqueous solution, adopt the method of spraying to coat the surface of the stent body, the solution flow rate is 0.25ml / min, the spray time is 30 seconds, repeat the above steps until the weight reaches 200ug, and form a continuous bottom layer on the surface of the stent body after drying. The stent containing the bottom layer was treated in 80% ethanol aqueous solution for 24 hours, washed with water, and vacuum-dried at room temperature. Then spray a mixed solution containing 5% silk protein and 2.5% chitosan on the bracket containing the bottom layer until the coating weight reaches 1000ug, and then dry naturally. Then soak the stent with water, quickly place it in a -80°C ultra-low temperature refrigerator to freeze for 2 hours, and then quickly transfer it to a pre-cooled freeze dryer and freeze-dry it for 18 hours to form a coating structure with micropores. Then, the above-mentioned coated stent with micropores was placed in an electric co...

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Abstract

The invention discloses an artificial blood vessel support and a preparation method thereof. The artificial blood vessel support consists of a support body and a coating on the surface of the support body, and is characterized in that the coating comprises a medicine carrying layer which comprises fibroin and medicines, wherein the medicine carrying layer is provided with a micropore structure which is mainly formed by the fibroin and used for carrying the medicines; a fibroin solution uniformly covers the surface of the blood vessel support body, and is subjected to thermal denaturation or chemical agent denaturation, infiltrated into purified water, and subjected to freezing and heat drying, so that the coating has the micropore structure; and the medicines are carried into a micropore of the coating, taken out and dried to obtain the artificial blood vessel support. The fibroin which is taken as a material of the coating of the artificial blood vessel support is natural protein, has good biocompatibility and no toxic side effect, and can be slowly absorbed and metabolized by the human body, and possible undesirable effects of the prior medicine support are overcome.

Description

technical field [0001] The invention relates to the technical field of biological materials and medical devices, in particular to an artificial vascular stent and a preparation method thereof. Background technique [0002] Silk is a natural protein composed of eighteen kinds of amino acids such as glycine, alanine, and serine. It is a natural fibrous polymer secreted by silkworms. It is mainly composed of repeated Gly-Ala-Gly-Ala-Ser polypeptide units. composed of. The structural characteristics of silk determine its biological activity, and the main amino acids that make up silk fibroin have special functions on the human body. [0003] my country is rich in silk resources, is a big silk producing country in the world, and is also the first country in the world to produce and use silk. For thousands of years, silk has been developed and utilized as a clothing and clothing item. Since the discovery of silk fibroin with unique physical and chemical properties and good compa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/10A61F2/82
CPCA61L31/10A61L31/16A61L31/146A61L2300/252A61L2300/606A61L2300/258C08L89/00
Inventor 罗七一唐智荣郑步中
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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