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Preparation method of animal medicine capable of clearing away the heat-evil and expelling the superficial evils, relieving cough and asthma

A technology for relieving cough, relieving asthma, clearing heat and detoxification, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, etc., and can solve problems such as unsatisfactory treatment effects.

Active Publication Date: 2012-07-04
PULIKE BIOLOGICAL ENG INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, antibiotics are the most widely used drugs. However, respiratory diseases are not a single bacterial infection. ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take 120.0 kg of ephedra, 80.0 kg of licorice, 120.0 kg of Radix Isatidis, 120.0 kg of Houttuynia cordata, 80.0 kg of Shandou root, 40.0 kg of Platycodon grandiflorum, 200 kg of gypsum, 120.0 kg of Scutellaria baicalensis and appropriate amount of water for injection.

[0042] The preparation method is:

[0043] (1) Extraction and concentration: take ephedra, licorice, Radix isatidis, houttuynia cordata, platycodon, raw gypsum, scutellaria, shandougen and other Baweijing medicinal materials into the extraction tank, add 8 times the amount of water, vacuum -0.08MPα or more, Keep it for 10 minutes and exhaust the vacuum for 10 minutes, then repeat it again. Under vacuum, boil at 60℃-80℃ for 2h, start refluxing for 4h, extract and concentrate to a relative density of 1.2-1.3 (60℃ heat test), and release the extract;

[0044] (2) Alcohol precipitation: put the concentrated solution in an alcohol precipitation tank and add ethanol to the alcohol content of 75%, stir evenly, and lea...

Embodiment 2

[0052] Take 200kg of ephedra, 100kg of licorice, 120.0kg of Radix Isatidis, 120.0kg of Houttuynia cordata, 80.0kg of Shandougen, 80kg of Platycodon grandiflorum, 280.0kg of raw gypsum, 120.0kg of Scutellaria baicalensis and appropriate amount of water for injection.

[0053] The preparation method is the same as in Example 1 except that the pH is adjusted to 6.0, and Tween-80 is 1.5% (weight percentage).

[0054] The formulation of the injection prepared by the invention is as follows:

[0055] Ephedra 120.0kg, Licorice 80.0kg, Radix isatidis 120.0kg, Houttuynia cordata 120.0kg, Shandou root 80.0kg, Platycodon grandiflorum 40.0kg, Gypsum 280.0kg, Scutellaria 120.0kg, Tween-80 25g-100g, Sodium bisulfite 10g- 40g, EDTA-2Na 5g-20g, NaCl 5g-10g, proper amount of hydrochloric acid, proper amount of water for injection.

Embodiment 3

[0057] Take ephedra 120.0kg, licorice 80.0kg, isatis root 120.0kg, houttuynia cordata 120.0kg, Shandou root 80.0kg, platycodon 40.0kg, gypsum 280.0kg, scutellaria 120.0kg, Tween-80 25g, sodium bisulfite 10g, EDTA -2Na 5g, NaCl 5g, proper amount of hydrochloric acid, proper amount of water for injection;

[0058] The preparation method is:

[0059] (1) Extraction and concentration: take ephedra, licorice, Radix isatidis, houttuynia cordata, platycodon, raw gypsum, scutellaria, shandougen and other Baweijing medicinal materials into the extraction tank, add 8 times the amount of water, vacuum -0.08MPα or more, Keep it for 10 minutes and exhaust the vacuum for 10 minutes, then repeat it again. Under vacuum, boil at 60℃-80℃ for 2h, start refluxing for 4h, extract and concentrate to a relative density of 1.2-1.3 (60℃ heat test), and release the extract;

[0060] (2) Alcohol precipitation: put the concentrated solution in an alcohol precipitation tank and add ethanol to the alcohol conten...

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PUM

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Abstract

The invention relates to a preparation method of a veterinary medicament having the efficacies of clearing heat-toxin and relieving cough and asthma. The veterinary medicament consists of 120.0kg to 200kg of Chinese ephedra, 80.0kg to 100kg of liquorice, 120.0kg of radices isatidis seu baphicacanthi, 120.0kg of herba houttuyniae, 80.0kg of euchresta japonica, 40.0kg to 80kg of radices platycodi, 200kg to 280.0kg of gypsum, 120.0kg of radices scutellariae and 1 percent to 1.5 percent of tween-80. The preparation method comprises a series of processing procedures including (1) extracting and concentrating, (2) alcohol deposition, (3) collecting alcohol, (4) water deposition, (5) concentration and the like; the veterinary medicament pertains to pure Chinese medicine preparation, has good curative effect for treating mycoplasma gallisepticum infection, is prepared by the good preparation technique and has the advantages of fast absorption, high utilization rate, no medicament residue or medicament resistance, and the like.

Description

Technical field: [0001] The invention relates to a method for preparing a veterinary drug, in particular to a method for preparing a veterinary drug with the effects of clearing away heat, detoxifying, relieving cough and relieving asthma. Background technique: [0002] Poultry farming occupies a considerable proportion of China’s aquaculture industry. However, due to the high density of poultry breeding, short growth cycle, and rapid spread of diseases, it has brought huge losses to the poultry breeding industry. Among them, respiratory diseases are the most common, More harmful diseases, especially in the alternate seasons of winter and spring or autumn and winter, due to the increase of various stress factors such as sudden changes in weather, respiratory diseases are extremely common, such as spreading, larynx, slow breathing, etc. are often accompanied by bacterial infections such as colibacillosis , Causing heavy losses to the breeding industry. In order to control avian r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K9/08A61K9/16A61P11/06A61P11/14A61K33/06
Inventor 张许科刘兴金张晓会姬丽萍杜丽丽赵玉静
Owner PULIKE BIOLOGICAL ENG INC