42results about How to "Broad pharmacological activity" patented technology

The invention discloses panax notoginseng active ingredient-containing medicinal toothpaste and a preparation method and application thereof. The panax notoginseng active ingredient-containing medicinal toothpaste comprises 0.1 to 0.4 weight percent of total panax notoginseng saponins and 0.2 to 0.5 weight percent of panax notoginseng polysaccharide which are panax notoginseng active ingredients,abrasive, a wetting agent, surfactant, a foaming agent, adhesive, a stabilizing agent and deionized water. The preparation method for the toothpaste comprises the following steps of: preparing materials, mixing, grinding, and degassing to obtain a toothpaste body. According to the toothpaste, total panax notoginseng saponins and panax notoginseng polysaccharide are used as the core functional components of the toothpaste, so that the toothpaste has the function of cleaning teeth, and the obvious effects of promoting recovery of dental ulcer, gingivitis and periodontitis, inhibiting swelling and aching of gums, relieving bleeding of gums, and delaying gingival atrophy and aging. The total panax notoginseng saponins and the panax notoginseng polysaccharide which are used as the active ingredients are natural plant extract, so that damage to ecological environment of normal flora in an oral cavity can be avoided, and the panax notoginseng active ingredient-containing medicinal toothpasteis suitable to be used for a long tome and is good in effect.

The invention relates to the field of livestock breeding, in particular to a natural plant feed additive. The natural plant feed additive is prepared from, by mass, 4-6 parts of pericarpium citri reticulatae, 3-5 parts of fleece flower roots, 5-7 parts of cortex fraxini, 3-5 parts of radix astragali, 2-4 parts of radix codonopsis, 4-6 parts of folium perillae, 3-5 parts of cyrtomium rhizomes, 5-7 parts of folium artemisiae argyi and 2-4 parts of lucid ganoderma. According to the feed additive, all the medicine materials are weighed according to the formula, dried, mixed and ground, and plant medicine materials pass through a 40-mesh screen, and are mixed evenly, separately packaged, sealed and preserved for use; the feed additive is added for feeding by 4% of feed. The natural plant feed additive is applied to raise animals, the quality of the animal food for the human is improved, the quality and flavors of eggs, milk and meat are improved, animal products are made safe and good in taste, and the old concept that people think that the taste of livestock and poultry products raised with feed is poor is changed. Meanwhile, the green concept of health and environment friendliness is reflected, and the humanistic feelings of returning to the original nature and returning to the nature are featured.

The invention provides a peeled burdock liquid fermentation medium, which is prepared from a peeled burdock root and water at the weight ratio of 1-15% (w/v). The invention further provides a method for fermenting edible fungi by adopting the fermentation medium. The method comprises the steps of strain activation, preparation of the liquid fermentation medium and liquid fermentation cultivation. The edible fungi can be effectively combined with the burdock root, so that solving of the difficulty of a narrow resource utilization range of burdock is facilitated, providing of a pure natural fermentation medium for the edible fungi is facilitated, the variety of the liquid fermentation medium for the edible fungi is enriched, and the peeled burdock liquid fermentation medium has important practical significance in optimization of burdock resource utilization and promotion of sustainable development of the edible fungi deep processing industry.

The invention discloses a method for improving the in-vitro fertilization effect of unfrozen pig sperms. The method comprises the following operation steps: (1) taking out frozen sperms, and unfreezing the frozen sperms; (2) cleaning the unfrozen seminal fluid with fertilization operating fluid, centrifuging twice, cleaning centrifugal precipitate with mTBM energetic fluid, centrifuging once, resuspending, and culturing to obtain energetic seminal fluid; (3) picking out a cumulus-oocyte complex from the ovary from which the follicular fluid is extracted under a microscope, culturing, taking out oocytes, and removing the cumulus; and (4) dropwise adding the obtained seminal fluid into each small fertilization cell, putting the small fertilization cells into an incubator for culture, and then washing off sperms attached to the oocytes to finish in-vitro fertilization culture. According to the invention, caffeic acid phenethyl ester and polyvinylpyrrolidone with corresponding concentrations are jointly added into the freezing base solution I, and the caffeic acid phenethyl ester and polyvinylpyrrolidone generate a synergistic effect so that the vitality, plasma membrane integrity rateand DNA integrity rate of the unfrozen pig sperms can be effectively improved, and the in-vitro fertilization effect of the unfrozen pig sperms is further improved.

The invention provides an antioxidant functional food prepared by probiotic solid-state fermentation. According to the antioxidant functional food, a mixture of sea buckthorn, fructus jujubae, lens, and soybeans is taken as a fermentation substrate, lactobacillus reuteri, bifidobacterium longum, pediococcus acidilactici, lactobacillus plantarum, bifidobacterium animalis, lactobacillus paracasei, bifidobacterium adolescentis, bacillus coagulans and bacillus subtilis are adopted, and the antioxidant functional food is prepared through solid-state segmentation fermentation. The antioxidant functional food prepared by probiotic solid-state fermentation has the effects of anti-aging, detoxification and beautification, freckle removing and whitening, and the like.

The invention provides a rabbit feed additive and rabbit feed using the additive, which can solve the problem that a traditional meat rabbit has strong offensive smell, and can avoid using antibiotics during a meat rabbit breeding process, so that the bred meat rabbit product is fresh, tender and firm in meat quality with high resilience. The rabbit feed additive is prepared from the following raw materials in parts by weight: 2000 to 2200 parts of folium artemisiae argyi, 2000 to 2200 parts of pine needle, 1500 to 2000 parts of folium isatidis, 1000 to 1500 parts of pericarpium citri reticulatae, 1000 to 1500 parts of herba houttuyniae, 800 to 1200 parts of herba andrographitis, 800 to 1200 parts of radix isatidis, 600 to 800 parts of radix sophorae flavescentis, 600 to 800 parts of radix astragalis, 600 to 800 parts of herba portulacae, 600 to 800 parts of herba taraxaci, 500 to 800 parts of radix astragalis, 500 to 1000 parts of radix glycyrrhizae, 500 to 1000 parts of folium perillae, 500 to 1000 parts of garlic, 500 to 800 parts of cassia bark, 250 to 500 parts of flos caryophylli, 250 to 500 parts of fructus anisi stellati, 300 to 400 parts of fresh ginger, 300 to 400 parts of radix angelicae sinensis,300 to 400 parts of herba menthae,300 to 400 parts of perilla nankinensis, 300 to 400 parts of cortex phellodendri, 300 to 400 parts of rhizoma atractylodis, 300 to 400 parts of radix sophorae flavescentis, 300 to 400 parts of herba portulacae, 300 to 400 parts of herba taraxaci, 300 to 400 parts of laminaria japonica root, 250 to 500 parts of fructus anisi stellati, and 200 to 250 parts of pepper.

The present invention relates to the field of chemical industry, particularly to a phloretin liposome and a preparation method thereof, wherein the phloretin liposome comprise 0.2-20 mg/mL of phloretin, 4-95% of phospholipid, 2-60% of cholesterol, and 0-90% of other auxiliary materials, wherein the phloretin liposome is prepared by using a stirring method, an ultrasonic dispersion method, a high-pressure homogenization method, a micro-jet dispersion method, a thin-film dispersion method, an injection method and a two-emulsification method. According to the preset invention, the prepared liposome has characteristics of high encapsulation efficiency, good stability, phloretin solubility improving, phloretin absorption promoting, targeting delivery, phloretin bioactivity improving, phloretin application scope expanding, and good social and economic values.

The present invention relates to compound amino acid capsules and a preparation method thereof, and belongs to the technical field of health food preparation. The compound amino acid capsules comprise the following four groups of components that (1) the first group of the components comprises 1-10 parts of a ginseng extract, and 1-10 parts of a panax notoginseng extract; (2) the second group of the components comprises 20-30 parts of tryptophan; (3) the third group of the components comprises 10-30 parts of leucine, 10-20 parts of phenylalanine, 20-50 parts of threonine, and 20-40 parts of valine; and (4) the fourth group of the components comprises 10-30 parts of arginine hydrochloride, 10-20 parts of histidine hydrochloride, 20-50 parts of isoleucine, 10-30 parts of lysine hydrochloride, and 40-80 parts of methionine. The preparation method comprises: respectively adding the four groups of the components into a sugarcoating jar, intermittently spraying an adhesive by using a high pressure spraying gun, continuously rolling the components in the pot and intermittently adding the components to prepare pellets, carrying out pellet selection, drying and coating on the prepared pellets, uniformly mixing, and loading into capsules so as to obtain the finished product. The compound amino acid capsules have characteristics of high active ingredient, strong functionality, stable performance, and convenient oral taking.

The invention discloses high-effectiveness healthcare oral liquid. The high-effectiveness healthcare oral liquid is prepared from, by weight, 5-10 parts of tricholoma matsutake mycelium, 3-5 parts of grifola frondosa mycelium, 5-8 parts of antrodia mycelium, 2-3 parts of lucid ganoderma mycelium, 10-25 parts of rhizoma atractylodis macrocephalae, 15-20 parts of radix codonopsis, 6-9 parts of spirulina and 8-12 parts of green tea. The invention further discloses a method for preparing the high-effectiveness healthcare oral liquid. According to the method, rhizoma atractylodis macrocephalae, radix codonopsis, spirulina and green tea are extracted and cooled naturally, then wall-broken tricholoma matsutake mycelium, grifola frondosa mycelium, antrodia mycelium, lucid ganoderma mycelium and fermentation liquor are added, and finally uniform mixing is conducted to obtain the high-effectiveness healthcare oral liquid. The oral liquid has an efficient radiation resisting effect, and is especially suitable for people working in the fields of guided missile and radar and in nuclear submarine troops where radiation hazard is serious.

The invention discloses high dietary fiber vine tea green juice powder and a preparation method thereof. The powder is prepared from the following raw materials in parts by weight: 8-10 parts of vinetea, 5-7 parts of strigose hydrangea juvenile leaves, 3-5 parts of mulberry leaves, 3-5 parts of chlorella, 1-3 parts of burdock, 1-2 parts of lotus leaves, 1-2 parts of sugar alcohol and 1-2 parts ofbamboo salt. The preparation method comprises the following steps: pre-treating the raw materials, performing secondary squeezing for the vine tea, strigose hydrangea juvenile leaves, mulberry leaves, chlorella and lotus leaves to obtain green juice, and performing drying and grinding to obtain a crude product green juice powder; directly drying and grinding the burdock to obtain burdock powder,mixing the burdock powder with the crude product green juice to obtain green juice powder, adding the bamboo salt and sugar alcohol into the green juice powder, performing uniform mixing and sterilizing to obtain the high dietary fiber vine tea green juice powder. The preparation method is simple, the green juice powder is rich in flavones, rubusosides and other active ingredients having remarkable effects for reducing blood glucose, blood pressure and blood fat, has rich dietary fibers, and is an ideal solid drink for the group with hypertension, hyperglycemia and hyperlipidemia.

The invention discloses a formula of granules prepared from roots of three-nerved spicebush, dendrobium candidum and ginseng and a preparing technology of the formula. The granules prepared from roots of three-nerved spicebush, dendrobium candidum and ginseng are prepared from, by weight, 10-40 parts of roots of three-nerved spicebush, 10-40 parts of ginseng, 10-40 parts of dendrobium candidum, 4-10 parts of yam, 6-12 parts of radix astragali, 4-10 parts of fructus lycii, 8-14 parts of malt, 4-10 parts of radix rehmanniae, 4-10 parts of white peony roots, 4-10 parts of radix angelica sinensis and 2-8 parts of honey. The preparing technology of the formula of the granules prepared from roots of three-nerved spicebush, dendrobium candidum and ginseng comprises the steps that firstly, raw materials are screened; secondly, mixing is carried out, thirdly, smashing and grinding are carried out; fourthly, honey is heated; fifthly, stirring is carried out; sixthly, the finished product is prepared, wherein according to a certain proportion by weight part, the raw materials are mixed and smashed and pass through a 100-mesh screen, medicine powder is obtained and then processed in cooperation with honey to obtain a semiproduct, and then granulation is carried out. The granules can enhance the immunity and have an auxiliary protection function on chemical liver injury.

The invention discloses health-care yoghurt containing resistant starch, fruit and vegetable juice and edible mushrooms. Fruit and vegetable raw materials are squeezed into juice at first, obtained pomace is utilized as an edible mushroom solid state fermentation medium to prepare edible mushroom mycoplasm powder, obtained part fruit and vegetable juice is utilized as an edible mushroom liquid state fermentation medium to prepare edible mushroom ball particles, then obtained edible mushroom mycoplasm powder enzymatic hydrolysate and the edible mushroom ball particles are mixed with primary fermentation yoghurt to be fermented to obtain the health-care yoghurt containing the resistant starch, the fruit and vegetable juice and the edible mushrooms, and the primary fermentation yoghurt is prepared from the raw materials of fresh milk, fruit and vegetable juice and the radix puerariae resistant starch. According to the health-care yoghurt disclosed by the invention, a nutritional and health-care effect of yoghurt is improved, types and tastes of yoghurt are enriched, and a consumption requirement of modern people in diversified healthy diet is met.

The invention discloses a method for improving the quality of unfrozen pig sperms, which comprises the following steps: (1) diluting collected qualified sperms by using a sperm protection diluent, andcarrying out constant-temperature balance treatment; (2) centrifuging the sperm, adding a frozen basic solution I into the obtained centrifugal precipitate, resuspending, and carrying out constant-temperature balancing treatment in a constant-temperature box; (3) adding the frozen basic liquid II into the container, uniformly mixing, filling into a thin tube, sealing, fumigating on liquid nitrogen or freezing by using a program freezer, and storing in the liquid nitrogen; and (4) when the sperm is unfrozen, taking out the tubule from the liquid nitrogen, incubating in a water bath kettle, andthen adding an unfreezing diluent to complete the unfreezing. According to the invention, caffeic acid phenethyl ester and hydroxyethyl starch with corresponding concentrations are jointly added intothe freezing base solution I, and the caffeic acid phenethyl ester and hydroxyethyl starch generate a synergistic effect, so that the vitality, plasma membrane integrity rate, acrosome integrity rateand DNA integrity rate of the unfrozen pig sperms can be effectively improved, and the quality of the frozen pig sperms is improved.

The invention discloses an application of a pueraria flower extract in preparation of drugs for preventing, treating and relieving inflammatory bowel diseases, protecting intestinal barriers and stabilizing intestinal morphology, provides a reliable anti-inflammatory agent to help to maintain the balance of the intestinal environment, and has the advantages of good curative effect on the inflammatory bowel diseases, low price and no obvious side effect. The invention finds and verifies that the pueraria flower extract has a remarkable curative effect on inflammatory bowel diseases, is low in price and side effect, and can macroscopically improve the intestinal inflammation state by improving the body health level, reducing the intestinal permeability, prolonging the intestinal length and the like. The pueraria flower extract can relieve excessive proliferation and differentiation of precursor cells caused by exogenous proinflammatory factors by negatively regulating an important factor, namely a JAK-STAT signal channel, of a colitis pathogenesis and maintain the homeostasis of intestinal cells, so that the effect of treating the inflammatory bowel disease is achieved.

The invention discloses a composition for improving anoxia tolerance.Active ingredients of the composition include, by weight, 20-100 parts of D-ribose, 1-10 parts of ginseng extract and 1-10 parts of Maca extract.The composition has the advantages that the composition can remarkably improve anoxia tolerance, and damage to organisms caused by anoxia can be reduced.

The invention discloses a glutamic acid production strain ands a preparation method and application thereof, and belongs to the field of bioengineering. The method comprises the following steps: fusing protoplast between corynebacterium glutamicum A (the preservation number is CGMCC NO.1. 10760) and corynebacterium glutamicum B (the preservation number is CGMCC NO.1. 1735), and performing mutationand regeneration so that the FM19-007 strain (CGMCC No. 18678) is obtained. The strain is characterized in that the strain is short-rod-shaped, spore-free and flagellate-free when observed under a microscope, gram staining is positive, the cell size is 0.7-1 * 1.2-3 [mu] m, and alpha-ketoglutarate dehydrogenase is lost; the glutamate dehydrogenase activity is high; glutamic acid is not used, glutamic acid feedback inhibition is relieved, and the capacity of secreting glutamic acid to the outside is achieved; in the fermentation process, obvious morphological change and cell membrane permeability change (forming cell leakage) occur at the decay stage. The mutant strain is fermented to produce glutamic acid, the yield of glutamic acid is 22%, the yield is increased by 51.72%, and the yieldof glutamic acid is remarkably increased.

The invention discloses a traditional Chinese medicine combination for treating hepatobiliary diseases and a preparation method thereof. The traditional Chinese medicine combination is composed of the following raw materials, by weight, of 200-300 parts of ganoderma lucidum soak solutions, 30-60 parts of antrodia camphorata polysaccharide, 70-100 parts of selenium-enriched pleurotus ostreatus fruiting body powder, 10-20 parts of bear bile powder, 100-200 parts of panax notoginseng powder, 80-120 parts of rock candies and 180-220 parts of tilia honey. The traditional Chinese medicine combination has good curative effect on treating liver cirrhosis, viral hepatitis type B, cholangitis, gallstones, a bile duct cancer and a gallbladder cancer.

The invention discloses a long-acting acne removal skincare composition. The long-acting acne removal skincare composition comprises, by weight, 0.1-10 parts of ononis spinosa, 0.1-10 parts of viscumcoloratum, 0.1-10 parts of carica papaya, 0.1-10 parts of drynaria fortunei and 0.1-10 parts of trigonella foenum-graecum. The long-acting acne removal skincare composition has the advantages that various medicines are used with one another, synergistic effects can be realized, abnormal hormone secretion can be regulated, the internal ecological balance of hair follicles can be regulated, accordingly, acne can be removed in a long-acting manner, and the problem of recurrent attack of acne can be solved by the aid of the acne removal skincare composition.

The invention provides a wormwood allergy-relieving repairing cream. The wormwood allergy-relieving repairing cream comprises the following raw materials in parts by weight: 3-10 parts of plant essential oil of wormwood, 8-15 parts of camellia oil, 3-8 parts of natural squalane, 2-8 parts of vitamin E, 3-8 parts of ceramide, 3-8 parts of nicotinamide, 5-10 parts of provitamin B5, 3-10 parts of an amino acid humectant, 0.3-0.8 part of allantoin and 2-7 parts of an emulsifier, with the balance being deionized water. A specific preparation method of the cream comprises the following steps: mixing the camellia oil, the natural squalane and the vitamin E, adding the emulsifier, and conducting melting to obtain an oil-phase mixture; mixing the ceramide, the nicotinamide, the provitamin B5, the amino acid humectant, the allantoin and the deionized water to obtain a water-phase mixture; and adding the water-phase mixture into the oil-phase mixture, conducting mixing to obtain a white emulsion matrix, performing natural cooling, and adding the plant essential oil of wormwood to obtain the wormwood allergy-relieving repairing cream. The wormwood allergy-relieving repairing cream prepared by the invention has the effects of resisting allergy and soothing and repairing skin.

The present invention relates to new prostaglandin derivatives having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of glaucoma and ocular hypertension.