Application of pueraria flower extract in preparation of medicine for preventing and treating inflammatory bowel disease

A technology of inflammatory bowel disease and kudzu flower extract, which is applied in the application field of kudzu flower extract in the preparation and prevention of inflammatory bowel disease drugs, which can solve the problems of body damage and accelerated death

Pending Publication Date: 2022-07-29
GANSU UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, excessive renewal of intestinal epithelial cells can cause irreparable damage to the body and even accelerate death

Method used

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  • Application of pueraria flower extract in preparation of medicine for preventing and treating inflammatory bowel disease
  • Application of pueraria flower extract in preparation of medicine for preventing and treating inflammatory bowel disease
  • Application of pueraria flower extract in preparation of medicine for preventing and treating inflammatory bowel disease

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Embodiment Construction

[0050] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0051] 1. Preparation of kudzu extract:

[0052] The dried kudzu flowers were mixed with 50% (V / V) methanol solution, and the mixture with a solid-liquid ratio of 1:30 was extracted with ultrasound at 70 °C for 2 hours. The extracted product was sequentially purified with petroleum ether, ethanol and chloroform-butanol, and gradually eluted with a mixed mobile phase of methanol-chloroform solution in a silica gel column system.

[0053] 2. Composition analysis of kudzu extract:

[0054] The components of kudzu extract were analyzed by LC-MS ion current chromatography. Chromatography of the standard eluted at a retention time of 30 min, confirming that the previously collected pueraria extract contained puerarin, daidzein, daidzein, rutin, apigenin and genistein (see figure 1 ).

[0055] 3. Instructions on the pre-administration method of Dros...

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Abstract

The invention discloses an application of a pueraria flower extract in preparation of drugs for preventing, treating and relieving inflammatory bowel diseases, protecting intestinal barriers and stabilizing intestinal morphology, provides a reliable anti-inflammatory agent to help to maintain the balance of the intestinal environment, and has the advantages of good curative effect on the inflammatory bowel diseases, low price and no obvious side effect. The invention finds and verifies that the pueraria flower extract has a remarkable curative effect on inflammatory bowel diseases, is low in price and side effect, and can macroscopically improve the intestinal inflammation state by improving the body health level, reducing the intestinal permeability, prolonging the intestinal length and the like. The pueraria flower extract can relieve excessive proliferation and differentiation of precursor cells caused by exogenous proinflammatory factors by negatively regulating an important factor, namely a JAK-STAT signal channel, of a colitis pathogenesis and maintain the homeostasis of intestinal cells, so that the effect of treating the inflammatory bowel disease is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of pueraria lobata extract in preparing medicines for preventing and treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a general term for a group of immune diseases of unknown etiology that affect the gastrointestinal tract. IBD patients have many characteristic symptoms of gastrointestinal diseases, such as discomfort, diarrhea, bloody stools, etc., and most patients also have extraintestinal complications, such as arthritis, dermatitis, and vision loss. Currently, there is no specific drug for IBD, and almost all drugs can only relieve symptoms. Due to the high recurrence rate and high treatment cost, it not only seriously affects the quality of life of patients, but also increases the mental and economic burden of patients. Therefore, finding safe and effective drugs has important theoretical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61P29/00A61P1/00A61P1/04A61K133/00
CPCA61K36/488A61P29/00A61P1/00A61P1/04
Inventor 和建政修明慧刘永琦杨世培李旭
Owner GANSU UNIV OF CHINESE MEDICINE
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