Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof

An active ingredient and toothpaste technology, which is applied in the field of medicinal toothpaste containing the active ingredient of Panax notoginseng and its preparation field, can solve the problems of only temporary effect, insignificant effect, and difficult control of active ingredients.

Active Publication Date: 2012-09-19
云南三七科技药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many heat-clearing, breath-removing, anti-moth, and anti-allergic toothpastes on the market. Although some toothpastes claim to solve gum bleeding, anti-inflammation, inhibit gum swelling, and repair oral ulcers, they can only solve some of the above problems. Either the effect is not obvious or can only play a temporary role,

Method used

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  • Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof
  • Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0014] In the pharmaceutical toothpaste containing notoginseng active ingredient: the friction agent is one or more of calcium hydrogen phosphate dihydrate, hydrated silica, calcium carbonate, and aluminum hydroxide accounting for 25-60% by weight of the toothpaste; The agent is one or more of glycerin, propylene glycol, and sorbitol that account for 10 to 55% by weight of the toothpaste; the surfactant and foaming agent are sodium lauryl sulfate, sodium lauryl sulfate, and 1.5 to 2.5% by weight of the toothpaste. One or more of sodium lauroyl sarcosinate; the binder is sodium carboxymethyl cellulose, carboxyethyl cellulose, xanthan gum, guar gum, cara One or several kinds of gums; the stabilizer is tetrasodium pyrophosphate accounting for 1.5-3.0% by weight of the toothpaste; the balance is deionized water.

[0015] In the pharmaceutical toothpaste containing the active ingredient of notoginseng: the friction agent is calcium hydrogen phosphate dihydrate and / or 20% to 35% hyd...

Embodiment 1

[0027] Prepare materials according to the following proportions (percentage by weight): 0.4% of Panax notoginseng saponins, 0.5% of Panax notoginseng polysaccharide, friction agent is 25% hydrated silica, wetting agent is 15% glycerin and 35% sorbitol, surface active The agent and foaming agent are 2.5% sodium lauryl sulfate, the binder is 1% sodium carboxymethylcellulose and 0.4% xanthan gum, the stabilizer is 3.0% tetrasodium pyrophosphate, and the rest is 17.2% % deionized water. Take the total saponins of notoginseng, notoginseng polysaccharide, tetrasodium pyrophosphate, and deionized water in the preparation materials, put them into the water phase device, fully mix and dissolve for use; put the friction agent, wetting agent, surfactant and foaming agent, Adhesives are added to the mixture respectively, and at the same time, they are continuously stirred with a mixer at a speed of 1000r / min for 40min until fully mixed, ground and degassed to form a paste, and packaged. ...

Embodiment 2

[0029] Prepare materials according to the following ratio (percentage by weight): 0.1% of Panax notoginseng saponins, 0.2% of Panax notoginseng polysaccharide, friction agent is 40% calcium hydrogen phosphate dihydrate and 20% hydrated silica, wetting agent is 10% Glycerin and sorbitol 15%, surfactant and foaming agent 1.5% sodium lauryl sulfate, binder 0.5% sodium carboxymethyl cellulose and 0.3% xanthan gum, stabilizer 1.5 % tetrasodium pyrophosphate, and the rest is 10.9% deionized water. Take the total saponins of notoginseng, notoginseng polysaccharide, tetrasodium pyrophosphate, and deionized water in the preparation materials, put them into the premixing device, fully mix and dissolve for use; put the friction agent, wetting agent, surfactant and foaming agent, Adhesives are added to the mixture respectively, and at the same time, they are continuously stirred with a mixer at a speed of 1000r / min for 25 minutes until fully mixed, ground and degassed to form a paste, and...

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Abstract

The invention discloses panax notoginseng active ingredient-containing medicinal toothpaste and a preparation method and application thereof. The panax notoginseng active ingredient-containing medicinal toothpaste comprises 0.1 to 0.4 weight percent of total panax notoginseng saponins and 0.2 to 0.5 weight percent of panax notoginseng polysaccharide which are panax notoginseng active ingredients,abrasive, a wetting agent, surfactant, a foaming agent, adhesive, a stabilizing agent and deionized water. The preparation method for the toothpaste comprises the following steps of: preparing materials, mixing, grinding, and degassing to obtain a toothpaste body. According to the toothpaste, total panax notoginseng saponins and panax notoginseng polysaccharide are used as the core functional components of the toothpaste, so that the toothpaste has the function of cleaning teeth, and the obvious effects of promoting recovery of dental ulcer, gingivitis and periodontitis, inhibiting swelling and aching of gums, relieving bleeding of gums, and delaying gingival atrophy and aging. The total panax notoginseng saponins and the panax notoginseng polysaccharide which are used as the active ingredients are natural plant extract, so that damage to ecological environment of normal flora in an oral cavity can be avoided, and the panax notoginseng active ingredient-containing medicinal toothpasteis suitable to be used for a long tome and is good in effect.

Description

technical field [0001] The invention relates to an oral cleaning care article, in particular to a medicinal toothpaste containing notoginseng active ingredients, a preparation method and application thereof. Background technique [0002] Radix Notoginseng is the dry root and rhizome of Araliaceae Panax Notoginseng (Burk.) F.H.Chen. Li Shizhen, a famous medical scientist in the Ming Dynasty, praised it as "gold does not change" in "Compendium of Materia Medica", and called it "North Ginseng and Southern Seven", and it is the most precious of traditional Chinese medicine. "Compendium of Materia Medica" says: "Notoginseng stops bleeding, disperses blood, and relieves pain." Modern scientific research shows that Panax notoginseng total saponins (PNS) contain 24 kinds of dammarane-type saponins, and its total saponin content is about 12%. , Panax notoginseng is known as "the king of ginseng". Panax notoginseng saponins include ginsenosides and notoginseng saponins, which are th...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q11/00A61P1/02A61K8/73
Inventor 杨长鑫赵洪李琼肖娜
Owner 云南三七科技药业有限公司
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