Biology source type calcified-layer containing cartilage tissue engineer bracket

A tissue engineering scaffold, bio-derived technology, applied in bone implants, medical science, prostheses, etc., can solve problems such as lack of mechanical function, defective quality of reconstructed tissues, poor integration of grafts and hosts, etc., to achieve enhanced The effect of interface integration and prevention of inter-organizational stratification

Inactive Publication Date: 2009-04-29
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Problems solved by technology

The reconstruction of engineered osteochondral composite tissue has achieved phased results from the preliminary exploration of the construction feasibility to the animal experiment study; the defects in the quality of the reconstructed tissue, th

Method used

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  • Biology source type calcified-layer containing cartilage tissue engineer bracket

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Embodiment 1

[0025] Such as figure 1 As shown, the scaffold of the present invention is composed of superficial cartilage layer 1, deep cartilage layer 2, calcified layer 3 and subchondral bone layer 4 from top to bottom, between cartilage layers 1, 2 and calcified layer 3, calcified layer 4 It is connected with the subchondral bone layer 4 by natural adhesive lines 5 and tide lines 6, and the superficial cartilage layer 1 and the deep cartilage layer 2 are connected by covalent bonds after mechanical stress and cross-linking treatment. The composition material of the cartilage layer 1 is type II collagen (medical use) or a mixture of type II collagen (medical use) and GAG (glucosaminoglycan); the weight ratio of type II collagen is 80% to 90%, and the weight ratio of GAG is 10% to 20% %, type II collagen / GAG is covalently bonded by cross-linking, and commercialized (Swiss Geiger Company) cartilage decellularized matrix slurry can be used. Its main components are: type II collagen and GAG;...

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Abstract

The invention discloses an engineering bracket made of biogenic cartilage tissue containing calcified layer bone. The bracket is a multi-layer structure, with one side of a substrate which contains at least one layer of acellular component and mainly takes II-typed collagen as main, the other side of subchondral bone structure containing at least one layer of acellular component and the middle of a calcified layer structure containing one acellular component. The calcified layer acellular structure removes the cell component structure and has the functions of normal calcified layer structure such as connection, stress decentralization, and separation of micro-environment between cartilage and subchondral bone. The engineering bracket is especially suitable for guiding the regeneration of bone and cartilage tissues and is beneficial for restoring the missing or destroyed bone and cartilage in vivo.

Description

technical field [0001] The invention relates to a medical device, in particular to a biologically derived osteochondral tissue engineering scaffold containing calcified layers. Background technique [0002] At present, osteochondral defects at the end of movable joints caused by trauma, infection, tumor and degeneration are common clinical orthopedic diseases, often manifested as intractable pain, joint movement disorders, severe cases may lose motor function, and cartilage damage will lead to further Cartilage wear and damage to articular surfaces. With the continuous increase of high-energy and high-speed trauma and the aging process of the population, the diseases that cause and accelerate the damage and degeneration of articular cartilage will increase significantly. The increasingly prominent articular cartilage damage has become a severe challenge for multiple disciplines such as trauma surgery, orthopedics, geriatrics, and sports medicine. Because articular cartilag...

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Application Information

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IPC IPC(8): A61L27/40A61F2/28A61L27/26A61L27/36
Inventor 谭洪波杨滨杨柳王富友段小军
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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