Biology source type calcified-layer containing cartilage tissue engineer bracket

Abstract

The invention discloses an engineering bracket made of biogenic cartilage tissue containing calcified layer bone. The bracket is a multi-layer structure, with one side of a substrate which contains at least one layer of acellular component and mainly takes II-typed collagen as main, the other side of subchondral bone structure containing at least one layer of acellular component and the middle of a calcified layer structure containing one acellular component. The calcified layer acellular structure removes the cell component structure and has the functions of normal calcified layer structure such as connection, stress decentralization, and separation of micro-environment between cartilage and subchondral bone. The engineering bracket is especially suitable for guiding the regeneration of bone and cartilage tissues and is beneficial for restoring the missing or destroyed bone and cartilage in vivo.

Description

technical field [0001] The invention relates to a medical device, in particular to a biologically derived osteochondral tissue engineering scaffold containing calcified layers. Background technique [0002] At present, osteochondral defects at the end of movable joints caused by trauma, infection, tumor and degeneration are common clinical orthopedic diseases, often manifested as intractable pain, joint movement disorders, severe cases may lose motor function, and cartilage damage will lead to further Cartilage wear and damage to articular surfaces. With the continuous increase of high-energy and high-speed trauma and the aging process of the population, the diseases that cause and accelerate the damage and degeneration of articular cartilage will increase significantly. The increasingly prominent articular cartilage damage has become a severe challenge for multiple disciplines such as trauma surgery, orthopedics, geriatrics, and sports medicine. Because articular cartilag...

AI Technical Summary

Problems solved by technology

The reconstruction of engineered osteochondral composite tissue has achieved phased results from the preliminary exploration of the construction feasibility to the animal experiment study; the defects in the quality of the reconstructed tissue, the inability to maintain the microenvironment for the growth of chondrocytes, the poor integration of the graft and the host, and the lack of corresponding mechanical functions are key factors. The main bottleneck limiting its clinical application

Images