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Combination of baicalin and atractylodes macrocephala lactone and preparation method thereof

A technique for atractylodes lactone and composition, which is applied in the field of compositions containing baicalin and atractylodes and their preparation, and can solve the problems such as blanks in preparation technology research and related screening, unclear pharmacological effects, etc.

Active Publication Date: 2009-05-06
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] To sum up, there are a lot of preliminary studies on the anti-abortion pharmacology of Scutellaria baicalensis and Atractylodes macrocephala respectively. Although there are reports on the anti-abortion prescriptions of the two combined prescriptions, the ratio of the two medicinal materials and the real pharmacology of the two The action part is not clear, therefore, the present invention has carried out systematic screening and research on the traditional Chinese medicine compound, and prepared the medicinal part with clear anti-abortion effect according to the modern preparation technology. blank

Method used

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  • Combination of baicalin and atractylodes macrocephala lactone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] [Example 1] Preparation of extracts containing Scutellaria baicalensis and Atractylodes Rhizoma

[0040] Take 250 kg each of Chinese medicinal materials Scutellaria baicalensis and Atractylodes Rhizoma, add 1 ton of 50% ethanol, heat under reflux for extraction for 3 hours, filter, and continue to add 1 ton of 5% ethanol to the medicinal residues. Reflux extraction for 2h, filter, and combine the two extracts. Recover the solvent under reduced pressure, at a temperature of 50-60 °C, concentrate to 6 times the volume of the original medicinal material, dilute the concentrate with 3 times of hot water, centrifuge, remove the precipitation, take the supernatant, and load it on a D101 macroporous resin column (in The resin column was pre-treated with acid, alkali, water and alcohol before sample loading), after sample loading, rinsed with 3BV pure water, discarded the aqueous solution, and eluted with 50% ethanol of 3BV instead, and the eluent flow rate was 1.5 BV / h, colle...

Embodiment 2

[0041] [Example 2] Preparation of extracts containing Scutellaria baicalensis and Atractylodes Rhizoma

[0042] Take 250 kg each of Chinese medicinal materials Scutellaria baicalensis and Atractylodes Rhizoma, add 1 ton of 80% ethanol, heat and reflux for extraction for 2 hours, filter, and continue to add 1 ton of 80% ethanol to the medicinal residues. Reflux extraction for 2h, filter, and combine the two extracts. Recover the solvent under reduced pressure, at a temperature of 50-60 °C, concentrate to 10 times the volume of the original medicinal material, dilute the concentrate with 5 times of hot water, centrifuge, remove the precipitation, take the supernatant, and load it on a D101 macroporous resin column (in The resin column was pre-treated with acid, alkali, water and alcohol before sample loading), after sample loading, rinsed with 3BV pure water, discarded the aqueous solution, and eluted with 3BV 80% ethanol instead, and the eluent flow rate was 1.5 BV / h, collect ...

Embodiment 3

[0043] [Example 3] Preparation of extracts containing Scutellaria baicalensis and Atractylodes Rhizoma

[0044] Scutellaria baicalensis and Atractylodes Rhizoma rhizomes are each 1000g, pulverized to a particle size of 70 mesh, dried and put into the extraction axe. The temperature is 50°C, the secondary decompression separation pressure is 7Mpa, the temperature is 45°C, and 80% ethanol is the entrainer. After 5 hours of dynamic operation, the total extract is obtained from the primary decompression separation axe and the secondary decompression separation axe. 6500ml, the extraction rate is 1.5%.

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Abstract

The invention discloses a combination which contains baikal skullcap root and atractylodes and is extracted from drug ingredients of baikal skullcap root and atractylodes. The combination also contains scutelloside and atractylodes lactone (I, II, III), wherein, the mass percent of the baikal skullcap root is 13 to 27 percent while the mass percent of the atractylodes lactone (I, II, III) is 0.5 to 2 percent. The preparation method of the combination can be a method of ethanol water hot reflux extraction added with large-hole resin and can also use a supercritical extraction method. The medical combination can be prepared by taking baikal skullcap root and atractylodes extract as drug action components and adding with pharmaceutic adjuvant acceptable in medical science or a medicine preparation can be prepared by a monomer, which can be used for curing and / or preventing fetal irritability and for protecting fetuses.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing baicalin and atractylide, as well as its preparation method and application in traditional Chinese medicines for child safety and infant protection, in particular to the use of the pharmaceutical composition in the treatment and / or prevention of fetal disturbance and the protection of infants applications in . Background technique [0002] Fetal leakage, restless fetal movement and slippery fetus, that is, threatened abortion and habitual abortion in Western medicine. Habitual abortion belongs to the category of "slippery pregnancy" in traditional Chinese medicine. It refers to the case of abortion or miscarriage occurring more than 3 times in a row, and the embryo spontaneously aborts within 12 weeks of pregnancy, which is called "abortion". Within 12 to 28 weeks of gestation, the fetus is formed and falls naturally, which is called "miscarriage". [0003] Western medicine mostly start...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P15/06A61K31/7048A61K31/365
Inventor 严启新高媛李勇李姿陈萍赵金华冯汉林
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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