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Combination of baicalin and atractylodes macrocephala lactone and preparation method thereof

A composition, the technology of Scutellaria baicalensis, applied in the field of composition containing baicalin and atractylodes lactone and its preparation, can solve the problems of partially unclear pharmacological effects, preparation process research and related screening blanks, etc.

Active Publication Date: 2013-11-13
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] To sum up, there are a lot of preliminary studies on the anti-abortion pharmacology of Scutellaria baicalensis and Atractylodes macrocephala respectively. Although there are reports on the anti-abortion prescriptions of the two combined prescriptions, the ratio of the two medicinal materials and the real pharmacology of the two The action part is not clear, therefore, the present invention has carried out systematic screening and research on the traditional Chinese medicine compound, and prepared the medicinal part with clear anti-abortion effect according to the modern preparation technology. blank

Method used

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  • Combination of baicalin and atractylodes macrocephala lactone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] [Example 1] Preparation of extract containing Scutellaria baicalensis and Atractylodes macrocephala

[0040] Take 250 kg each of Scutellaria baicalensis and Atractylodes macrocephala, add 1 ton of 50% ethanol, heat and reflux for extraction for 3 hours, filter, and add 1 ton of 5% ethanol to the dregs. Reflux for extraction for 2 hours, filter, and combine the two extracts. The solvent is recovered under reduced pressure, the temperature is 50-60 ° C, concentrated to 6 times the volume of the original medicinal material, the concentrated solution is diluted with 3 times hot water, centrifuged, and the precipitate is removed. The supernatant is taken and loaded on a D101 macroporous resin column (in Respectively use acid, alkali, water, alcohol to pre-treat the resin column before sample loading), rinse with 3BV pure water after sample loading, discard the aqueous solution, and use 3BV of 50% ethanol to elute, the flow rate of the eluent is 1.5 BV / h, collect the ethanol...

Embodiment 2

[0041] [Example 2] Preparation of extract containing Scutellaria baicalensis and Atractylodes macrocephala

[0042] Take 250 kg of Chinese medicinal materials Scutellaria baicalensis and Atractylodes macrocephala, add 1 ton of 80% ethanol, heat and reflux for extraction for 2 hours, filter, and add 1 ton of 80% ethanol to the dregs. Reflux for extraction for 2 hours, filter, and combine the two extracts. Recover the solvent under reduced pressure, at a temperature of 50-60°C, concentrate to 10 times the volume of the original medicinal material, dilute the concentrated solution with 5 times hot water, centrifuge, remove the precipitate, take the supernatant, and load it on a D101 macroporous resin column ( Respectively use acid, alkali, water, alcohol to pre-treat the resin column before sample loading), rinse with 3BV pure water after sample loading, discard the aqueous solution, and use 3BV of 80% ethanol to elute instead, and the eluent flow rate is 1.5BV / h, collect the et...

Embodiment 3

[0043] [Example 3] Preparation of extract containing Scutellaria baicalensis and Atractylodes macrocephala

[0044] Scutellaria baicalensis and rhizome of Atractylodes macrocephala each 1000g, pulverized to a particle size of 70 mesh, put into the extraction ax after drying, the extraction conditions are: the extraction pressure is 25Mpa, the temperature is 50°C, the separation conditions are: the first-stage decompression separation pressure is 8Mpa, The temperature is 50°C, the pressure of the secondary decompression separation is 7Mpa, the temperature is 45°C, and 80% ethanol is used as the entrainer. After dynamic operation for 5 hours, the total extract is obtained from the first decompression separation ax and the second decompression separation ax 6500ml, the extraction rate is 1.5%.

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Abstract

The invention discloses a combination which contains baikal skullcap root and atractylodes and is extracted from drug ingredients of baikal skullcap root and atractylodes. The combination also contains scutelloside and atractylodes lactone (I, II, III), wherein, the mass percent of the baikal skullcap root is 13 to 27 percent while the mass percent of the atractylodes lactone (I, II, III) is 0.5 to 2 percent. The preparation method of the combination can be a method of ethanol water hot reflux extraction added with large-hole resin and can also use a supercritical extraction method. The medical combination can be prepared by taking baikal skullcap root and atractylodes extract as drug action components and adding with pharmaceutic adjuvant acceptable in medical science or a medicine preparation can be prepared by a monomer, which can be used for curing and / or preventing fetal irritability and for protecting fetuses.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition containing baicalin and atractylodes lactone, as well as its preparation method and its application in anti-fetal and infant-protecting traditional Chinese medicine, especially relates to the pharmaceutical composition in the treatment and / or prevention of fetal restlessness and its protection of infants in the application. Background technique [0002] Fetal leakage, restless fetal movement and fetal slippage are threatened abortion and habitual abortion in Western medicine. Habitual abortion belongs to the category of "abortion" in traditional Chinese medicine. It refers to those who have abortions or miscarriages for more than 3 times in a row, and those whose embryos are naturally lost within 12 weeks of pregnancy are called "abortions". Within 12 to 28 weeks of gestation, if the fetus has formed and falls naturally, it is called "miscarriage". [0003] Western medicine mostly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539
Inventor 严启新高媛李勇李姿陈萍赵金华冯汉林
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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