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Multifunctional female pelvic cavity biological sticking patch

A biological patch and multifunctional technology, applied in medical science, muscles, ligaments, etc., can solve the problems of easy degradation failure, failure, rejection, etc., and achieve superior histocompatibility, reasonable structural design, and not easy to degrade Effect

Active Publication Date: 2009-05-13
上海冠昊医疗器械有限公司
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, due to the backward treatment technology of cadaver skin, it is only applied after simple decellularization, soaking in alcohol or glutaraldehyde for disinfection and fixation treatment. The stability is poor, and it is easy to degrade and fail after implantation.
The immunogenicity cannot be effectively removed, and rejection often occurs and fails

Method used

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  • Multifunctional female pelvic cavity biological sticking patch
  • Multifunctional female pelvic cavity biological sticking patch

Examples

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Embodiment Construction

[0024] Put the animal membrane tissue into 0.1% bromogeramine solution for disinfection for 30 minutes, take it out, cut off the impurities, soak it in 95% alcohol for 60 minutes, put it into ether for extraction for 4 hours, take it out, put it in a fume hood to air dry, put it in In the decellularization reactor, add protease, enzymolysis for 4 to 12 hours, take it out and wash it, put it into the fixation reactor, and add the fixation reagent shown in the following formula: (here R=C n h 2n+1 -or Here n=0, 1, 2, 3 ... 12), make fixed reaction 8~96 hours, take out and wash, put into the antigen removal reactor, add nucleophilic reagent (such as acid anhydride or acid chloride) earlier and make reaction 8 ~ 24 hours, pour out the reaction liquid, wash the reactor and the membrane material twice with water, and then replace the guanidine compound, and let the reaction last for 4 ~ 16 hours. Take it out, wash it, put it into the mechanical modification reactor, and add the...

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Abstract

The invention discloses a structure and a preparation method of a multifunctional woman pelvic biological repair plate. The biological repair plate takes natural biomembranes as raw material, is processed through a series of biochemical technology, increases the stability greatly, and is made through remachining shaping and activity-modifying. The stability of the material is high, the biocompatibility is good, the ingrowth for autologous nerve structures of a patient can be induced, and the supporting and fixing functions of the autologous nerve structures can be served. The morphological structure of the multifunctional woman pelvic biological repair plate comprises a head, double wings and a bosom body, and likes a tailless mosquito hawk, as shown in an attached drawing. The structure is designed according to years of clinical experience of an inventer, the adaptability is wide, the practicability is strong, and the multifunctional woman pelvic biological repair plate can be used in multiple situations such as posterior vaginal wall prolapse, musculus levator ani laceration, uterosacral ligament slack, rectovaginal diaphragm defect, rectovaginal fistula repair, vaginal contraction, etc.

Description

technical field [0001] The multifunctional female pelvic biological patch of the invention relates to an implantable Class III medical device. Background technique [0002] Female pelvic floor dysfunction is a common disease and frequently-occurring disease in middle-aged and elderly women over 50 years old, which seriously affects the life and health of middle-aged and elderly women. The current treatment method is to use some medical synthetic materials (such as polypropylene, tetrafluoroethylene, etc.) mesh belt or sheet to reconstruct the pelvic floor function through surgery. Due to the poor biocompatibility of synthetic materials, it is easy to cause discomfort and pain caused by foreign body stimulation, coupled with aging, hardening and brittleness, friction, displacement, erosion and other effects in the body, adverse complications such as puncture of the bladder and vagina often occur . In order to overcome these disadvantages, some scholars have tried decellular...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61L27/36
Inventor 徐国风童晓文徐斌
Owner 上海冠昊医疗器械有限公司
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