Chinese medicine granule containing haw thorn extract and preparation method thereof
A technology of hawthorn extract and traditional Chinese medicine granules, which can be applied to medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations without active ingredients, etc. Aesthetics and other issues, to achieve the effect of good physical properties, small specific surface area, and regular particle size distribution
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Embodiment 1
[0049] Take hawthorn and extract 3 times in total. Add 7 times the amount of 70% ethanol for 0.5 hours for the first time, add 6 times the amount of 70% ethanol for 0.5 hours for the second time, add 6 times the amount of 70% for the third time Extract with ethanol for 0.5 hours, let it stand overnight, filter, concentrate the filtrate, recover ethanol, pass the concentrated solution through a macroporous adsorption resin, add an appropriate amount of water to elute, and then elute with 30% ethanol, combine the concentrated solution and polycellulose amine, Washing with water, washing with 50% ethanol, and concentrating to obtain hawthorn extract.
[0050] Preparation of masterbatch: Take dextrin and starch in a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and the starch is added with water to prepare starch slurry (15%) Spray it in as a slurry, and sieve out small particles (180...
Embodiment 2
[0053] Get an appropriate amount of the hawthorn extract obtained according to the method of Example 1;
[0054] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as a base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in to make the particle size of the mother core grow, and the master batch with a particle size of 200μ-300μ is screened out for use.
[0055] Preparation of the product: take 300g of masterbatch, 250g of microcrystalline cellulose (200 mesh...
Embodiment 3
[0057] Get an appropriate amount of the hawthorn extract obtained according to the method of Example 1;
[0058] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200 mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to make the particle size of the mother core grow, and screen out the master batch with a particle size of 300μ-400μ for future use.
[0059] Preparation of the product: Take 450g of masterbatch, 50g of microcrystalline cellulose (200 mesh), polyethylene ...
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