Use of glaucocalyxin X in preparing anti-cancer medicine

An anti-cancer drug, the technology of Indigo calyx, which is applied in the field of medicine, can solve the problems such as the lack of anti-cancer activity of Indigo calyx X

Inactive Publication Date: 2009-06-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far there is no report about the anticancer activity of calyxin X

Method used

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  • Use of glaucocalyxin X in preparing anti-cancer medicine
  • Use of glaucocalyxin X in preparing anti-cancer medicine
  • Use of glaucocalyxin X in preparing anti-cancer medicine

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The present invention will be described in detail below through in vitro anti-tumor experiments.

[0010] In Vitro Antitumor Activity Test of Cerulein X

[0011] 1. Experimental drug:

[0012] The blue calyx X is isolated from the blue calyx, and the preparation method is detailed in [Zhao BaoXiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al.Two new diterpenoids from Rabdosia japonica var. glaucocalyx, Chinese Chemical Letter2008; 19:852-854].

[0013] Control drug: doxycycline (DOX), Shijiazhuang Ruitian Biochemical Co., Ltd.

[0014] 2. Cell line: provided by the Pharmacology Laboratory of Shanghai Institute of Pharmaceutical Industry

[0015] ①A549 (human lung cancer cells); ②LOVO (human intestinal cancer cells); ③6T-CEM (human T-cell leukemia cells); ④HL-60 (human leukemia cells)

[0016] 3. Culture medium: RPMI1640+15%NBS+double antibody

[0017] 4 Other materials

[0018] Fully automatic microplate reader: Model: (WellscanMK-2) Manufacturer: Labsy...

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Abstract

The present invention relates to technical field of medicine, and relates to the use of diterperoid compound glaucocalyxin X in isodon japonica (Burm.f) Hara var.glaucocalyx (Maxim.) Hara in preparing anti-cancer medicine. The invention adopts an MTT method for executing cytotoxicity experiment. The result shows that the glaucocalyxin X equally has remarkable cytotoxicity and therefore can be used for preparing anti-cancer medicine. The invention provides a new source for preparing the anti-cancer medicine.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to the use of indigo-X in the preparation of anticancer drugs. Background technique [0002] Glaucocalyxin X (Glaucocalyxin X) is isolated from the whole plant of Glaucocalyx (Rabdosia japonica (Burm.f.) Hara var. glaucocalyx (Maxim.) Hara) by the present inventors. The obtained new compound [Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (陈海生), et al.Two new diterpenoids from Rabdosiajaponica var. glaucocalyx, Chinese Chemical Letter 2008; 19:852-854]. [0003] The chemical structure of Cerulein X is as follows: [0004] [0005] So far, there is no report about the anticancer activity of calyxin X. Contents of the invention [0006] The invention provides an application of the calyxin for the preparation of anticancer drugs. [0007] The present invention adopts MTT method, with A549 (human lung cancer cells), LOVO (human intestinal cancer cells), 6T-CEM (human T-cell leuk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P35/00
Inventor 陈海生项昭保刘建国金永生赵卫权
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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