Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of detection method of traditional Chinese medicine liquid preparation

A technology for liquid preparations and detection methods is applied in the field of quality control for the method detection of two traditional Chinese medicine ingredients in traditional Chinese medicine preparations, which can solve the problems of time-consuming and laborious, waste of organic solvents, waste of samples and reagents, etc., to save consumables and reagents, reduce Experiment time, inspection effect is good

Active Publication Date: 2012-02-22
BEIJING TONGRENTANG CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing Chinese medicine preparations, especially compound Chinese medicine preparations, when the quality control method is used to identify more than two kinds of Chinese medicine ingredients in the compound preparation, the commonly used method is to use thin-layer chromatography to examine different Chinese medicine ingredients separately. The method is repetitive, cumbersome, and time consuming
Taking the Chinese patent medicine containing Phellodendron Phellodendron and Dipsacus as an example, it is generally necessary to identify Phellodendron Phellodendron and Dipsacus Dipsacus separately, which increases the operation steps, takes a long time, wastes samples and reagents, and also causes excessive waste of organic solvents and increases pollution.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1, the detection method of Phellodendron Phellodendron and Dipsacus in compound eucommia strong waist wine

[0050] Compound eucommia strong waist wine is made from 11 herbs such as Eucommia ulmoides, Sangjisheng, Dipsacus, Achyranthes bidentata, psoraleae, antlers, turtle shell (made with vinegar), angelica, corydalis, woody fragrance, and cortex officinalis Health wine.

[0051] The detection method is:

[0052] 1. To prepare the test solution, first use about 50ml of the sample (i.e. compound Eucommia strong waist wine), concentrate it in a water bath to about 30ml, shake and extract with about 30ml of ether, take the water layer, evaporate to dryness in a water bath, add 15ml of water to the residue to dissolve, and Shake and extract saturated n-butanol for 3 times, 20ml each time, combine the n-butanol solution, wash twice with 1% sodium hydroxide solution, 50ml each time, then wash with 50ml water saturated with n-butanol, and take n-butanol Alcoholic...

Embodiment 2

[0060] Embodiment 2, the detection method of Phellodendron Phellodendron and Dipsacus in Guogong Liquor

[0061] 1. To prepare the test solution, first use about 50ml of the sample (i.e. Guogong wine), concentrate it in a water bath to about 30ml, shake and extract it with about 30ml of diethyl ether, take the water layer, evaporate it to dryness in a water bath, add 12-18ml of water to the residue to dissolve, and use water to dissolve the solution. 50-80ml of saturated n-butanol is shaken and extracted, the n-butanol solution is washed with 50-100ml of 0.5-1.5% sodium hydroxide solution, and then washed with 40-80ml of n-butanol-saturated water, and the n-butanol solution is taken, Evaporate to dryness, add 1-5ml of methanol to the residue to dissolve, and use it as the test solution; the sample is Guogong liquor;

[0062] 2. Prepare the reference solution: as above;

[0063] 3. Adopt thin-layer chromatography to detect:

[0064] 3.1 According to the thin-layer chromatogra...

Embodiment 3

[0069] Embodiment three, the detection method of comparative example

[0070]The comparative example is the compound eucommia ulmoides strong waist wine with Phellodendron Cortex and Dipsacus deleted, which is composed of Eucommia ulmoides, Sangjisheng, Achyranthes bidentata, psoraleae, antlers, turtle shell (made with vinegar), angelica, corydalis, and woody nine medicinal materials according to ten medicinal materials. The control medicinal wine prepared by boiling the above-mentioned component content of the compound Eucommia strong waist wine composed of a single traditional Chinese medicine.

[0071] The detection method is:

[0072] 1. To prepare the test solution, first use about 50ml of the sample (i.e. the reference medicinal wine), concentrate it in a water bath to about 30ml, shake and extract with about 30ml of diethyl ether, take the water layer, evaporate it to dryness in a water bath, add 15ml of water to the residue to dissolve, and water-saturated Shake and e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a detection method of Chinese medicine liquid preparation containing Phellodendron Phellodendri and Dipsacus, comprising: preparing the test solution; preparing three kinds of control solutions, including Dipsacus reference medicinal solution, Dipsacus saponin VI and Berberis hydrochloride Alkaline reference substance solution; using thin-layer chromatography, using the upper layer solution of n-butanol-acetic acid-water as a developer, first detect at an ultraviolet wavelength of 300-400nm, and observe the fluorescent spots displayed on the silica gel G thin-layer plate And spot color; Spray sulfuric acid ethanol solution on this silica gel G thin-layer plate again, heat, observe the spot and the spot color shown on this silica gel G thin-layer plate; Whether contain Phellodendron Phellodendron in the Chinese medicine liquid preparation with the spot situation observed and Dipsacus; the method of the present invention enables simultaneous identification of two kinds of medicinal materials on the same thin-layer board, which not only simplifies operation, reduces experiment time, saves consumables and reagents, but also improves efficiency.

Description

technical field [0001] The invention provides a quality control method, which is a method for detecting a certain Chinese medicine component in a Chinese medicine preparation, in particular, a quality control method for detecting two kinds of Chinese medicine ingredients in a Chinese medicine preparation by using one method. Background technique [0002] Existing Chinese medicine preparations, especially compound Chinese medicine preparations, when the quality control method is used to identify more than two kinds of Chinese medicine ingredients in the compound preparation, the commonly used method is to use thin-layer chromatography to examine different Chinese medicine ingredients separately. The method is repetitive, cumbersome, and Time consuming and laborious. Taking the Chinese patent medicine containing Phellodendron Phellodendron and Dipsacus as an example, usually Phellodendron Phellodendron and Dipsacus are identified separately, which increases the operation steps...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90A61K36/756A61K36/185
Inventor 李银杜菁彭鹏王檀王铭文
Owner BEIJING TONGRENTANG CO LTD