Cordyceps sinensis sustained and controlled release capsule and preparation method thereof

A Cordyceps Suspension and Capsule Technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as adverse overall health level, low dissolution rate, and long dissolution time limit to enhance human immunity. , the effect of reducing toxic and side effects and reducing the frequency of medication

A Cordyceps Suspension and Capsule Technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as adverse overall health level, low dissolution rate, and long dissolution time limit to enhance human immunity. , the effect of reducing toxic and side effects and reducing the frequency of medication

CN101480415AInactive Publication Date: 2009-07-15JILIN UNIV
0 Cites 6 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cordyceps sinensis sustained and controlled release capsule and preparation method thereof
  • Cordyceps sinensis sustained and controlled release capsule and preparation method thereof
  • Cordyceps sinensis sustained and controlled release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Cordyceps sustained-release capsules (specification: 10mg)

[0030] 1 Prescription: (1000 tablets for 10mg)

[0031] (1) Prepare drug-loaded pellets according to the following prescription:

[0032] Cordyceps active extract 80g, polyethylene glycol-4000 15g, polyvinylpyrrolidone 3g, 50% ethanol 10g, magnesium stearate 0.5g.

[0033] Immediate-release pellets were prepared according to the following formulation:

[0034] Drug-loaded pellets 100g, carboxypropylmethylcellulose 2.5g, polyethylene glycol-4000 15g;

[0035] Sustained-release pellets were prepared according to the following prescription:

[0036] Drug-loaded pellets 100g, carboxyethyl cellulose 20g, polyethylene glycol-6000 15g;

[0037] 2 Preparation method:

[0038] (1) Weigh the active extract of Cordyceps sinensis of prescription quantity, put polyethylene glycol-4000, polyvinylpyrrolidone in the mixer and mix evenly, add 50% ethanol to make soft material, sieve through 20-60 mesh, carr...

Embodiment 2

[0044] Preparation of Cordyceps capsules (specification: 10mg)

[0045] 1. Prescription (1000 tablets for 10 mg)

[0046] (1) Prepare drug-loaded pellets according to the following prescription:

[0047] Cordyceps active extract 80g, mannitol 37g, crospovidone 15g, PEG-2000 30g, 50% ethanol 10g, talcum powder 0.5g.

[0048] Immediate-release pellets were prepared according to the following formulation:

[0049] Drug-loaded pellets 100g, croscarmellose sodium 15g, PEG-2000 30g;

[0050] Sustained-release pellets were prepared according to the following prescription:

[0051] Drug-loaded pellets 100g, ethyl cellulose 15g, PEG-2000 30g;

[0052] 2 Preparation method:

[0053] (1) The active extract of Cordyceps sinensis, mannitol, crospovidone, and PEG-4000 are placed in a mixer to mix evenly, and an appropriate amount of 50% ethanol is added to make a soft material, and 20-60 meshes are sieved. Perform wet granulation.

[0054] (2) Dry at 40-60°C, and sieve the granules w...

Embodiment 3

[0059] Preparation of Cordyceps capsules (specification: 10mg)

[0060] 1. Prescription (1000 tablets for 10 mg)

[0061] (1) Prepare drug-loaded pellets according to the following prescription:

[0062] 80 parts of Cordyceps active extract, 15 parts of crospovidone, 15 parts of dextrin, 30 parts of PEG-1000, 5 parts of 50% ethanol, 0.5 parts of talcum powder, 5 parts of dilute alkali;

[0063] Immediate-release pellets were prepared according to the following formulation:

[0064] 100 parts of drug-loaded pellets, 37 parts of microcrystalline cellulose, 30 parts of PEG-1000;

[0065] Sustained-release pellets were prepared according to the following prescription:

[0066] 100 parts of drug-loaded pellets, 15 parts of croscarmellose sodium, 30 parts of PEG-4000;

[0067] 2 Preparation method:

[0068] (1) Take the active extract of Cordyceps sinensis of prescription quantity and place in the mixer with crospovidone, PEG-1000, dextrin and mix evenly, add appropriate amount...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a worm grass slowly controlled release capsule and a preparation method thereof. The capsule comprises 5 parts to 50 parts of quick release pillers and 50 parts to 95 parts of slow release pillers, each quick release piller comprises a core for carrying a pill and a protective layer, each slow release piller comprises a core for carrying a pill and a slowly controlled release coating layer, and the capsule has the dose of 30mg to 100mg. Medicine continuously released by the worm grass slowly controlled release capsule outside a body can reach more than 90 percent in 24 hours, a patient only needs to take medicine once every day, so times for taking medicine every day can be obviously reduced, the toxic side effect of medicine is lowered, the adaptability of the patient is enhanced and the abuse of medicine is not easy to occur.

Description

Technical field: [0001] The invention relates to a cordyceps slow-release and controlled-release capsule and a preparation method thereof, belonging to the technical field of extraction and application of active ingredients of traditional Chinese medicines. technical background: [0002] Cordyceps sinensis, also known as Cordyceps sinensis and Cordyceps sinensis, is a complex of larvae and larval corpses parasitized on the larvae of the larvae of the family Mothidae. Cordyceps sinensis is a traditional precious nourishing Chinese medicinal material, which is listed as the three major nourishing products together with natural ginseng and deer antler. It has mild medicinal properties and can be eaten all year round. It is suitable for the old, young, sick, weak, and weak. It has wider medicinal value than other types of tonics. Under the condition that the supply of Cordyceps sinensis is in short supply, its development and production have developed new sources of nutrition a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
15 Jul 2009
Publication
CN101480415A
IPC
A61K36/068; A61K9/52; A61P3/06; A61P9/10; A61P25/20; A61P29/00; A61P31/04; A61P35/00; A61P39/00
Inventors
滕利荣; 逯家辉