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Three-dimensional photo-stimulation system

A light stimulation, three-dimensional technology, applied in optics, nonlinear optics, medical science, etc., can solve the limitations of three-dimensional stimulation and other problems

Inactive Publication Date: 2009-07-15
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a three-dimensional optical stimulation system aiming at the limitation that the existing optical stimulation method cannot realize three-dimensional stimulation. Realization of writing different phase holograms into spatial light modulator

Method used

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Examples

Experimental program
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Effect test

example 1

[0040] Such as image 3 , the stimulating light source is a 632.8nm He-Ne laser, the spatial light modulator is 512×512, the pixel size is 10μm, and the focal length of the lens is 250mm. When it is necessary to form two stimulation points whose position coordinates are respectively (0.1, 0.1, 50) mm and (-0.1, -0.1, -50) mm, according to formulas (3) to (7), the computer 13 can be input to The phase hologram of the spatial light modulator is shown as Figure 4 , and then put as Figure 4The phase hologram of the phase is input into the spatial light modulator. After the stimulation light passes through the spatial light modulator and the lens, the stimulation points with position coordinates of (0.1, 0.1, 50) and (0.1, 0.1, -50) mm can be formed. . These two stimulation points not only have different horizontal coordinates, but also different axial coordinates.

example 2

[0042] Such as image 3 , the stimulus light source is a 632.8nm He-Ne laser, the spatial light modulator is 512×512, the pixel size is 10μm, and the focal length of the lens is 250mm. When it is necessary to form four stimulus points whose position coordinates are (0.1, 0, 0), (0.2, 0, 0), (0, 0, 50) and (0, 0, 70) mm, according to (3) To (7), the computer 13 can obtain the phase hologram input to the spatial light modulator as Figure 5 , and then put as Figure 5 The phase hologram of the input into the spatial light modulator, after the stimulation light passes through the spatial light modulator and the lens, the position coordinates can be formed respectively (0.1, 0, 0), (0.2, 0, 0), (0, 0, 50) and (0, 0, 70) mm stimulation points. These four points are distributed in different positions in the three-dimensional space.

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Abstract

The invention relates to a three-dimensional light stimulus system comprising a laser, a neutral color filter, a polaroid sheet, a plane mirror, four lenses, a space light modulator, a computer, a dichroscope and an objective lens, the stimulus light transmitted by the laser is incident on the space light modulator through the neutral color filter, the polaroid sheet, the plane mirror and two lenses in order, the computer is connected with the space light modulator and controls the stimulus light generated incident by the space light modulator to generate a bit phase and to modulate into a stimulus light of diffraction pattern, the stimulus light is irradiated by the two lenses, the dichroscope and the objective lens to the nearby area of the sample to form the stimulus pattern of three-dimensional space distribution. The invention has advantages that, a plurality of stimulus points distributed in the three-dimensional space are formed simultaneously, and the position can be changed arbitrarily; the three-dimensional area of any shape can be stimulated. The invention can be applied to the research of the stimulus response, can combine with the biomedical observation system, can provide the means for the biology and medicine researches, and can be extensively used for the researches of chemical and physical and so on a plurality of academic subjects.

Description

technical field [0001] The invention relates to a novel three-dimensional light stimulation system, which can be used in the research of neurobiology and other disciplines in combination with microscopic imaging methods and electrophysiological methods. Background technique [0002] Stimulating nerve cells with light is a common method to study the rules of nerve cell activity. Since the spatial position and time sequence of optical stimulation can be controlled by optical devices, complex physiological activities of nerve cells can be simulated, which provides a basic experimental method for understanding the rules of nerve cell activity. With the development of new optical devices, the ways of light stimulation become diversified, which provides more abundant experimental techniques for studying the rules of nerve cell activity. The development of new photostimulation methods is an urgent need for neurobiological research. [0003] In S.Wang's article "Rapid neurotransmi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02F1/35A61B5/04
Inventor 骆清铭曾绍群杜睿
Owner HUAZHONG UNIV OF SCI & TECH
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