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Composition and application thereof as scurf-eliminating and itch-stopping agent

A composition and a technology for removing dandruff are applied in the application of anti-dandruff and antipruritic agents, in the field of compositions comprising an iodopropynyl compound and a benzamidine compound, which can solve the problems of insignificant anti-dandruff effect and the like, and achieve synergy and synergy. Antidandruff and antipruritic effect, good formula compatibility, excellent antidandruff and antipruritic properties or effects

Active Publication Date: 2009-07-22
南京枫华投资管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a composition comprising an iodopropynyl compound and a benzamidine compound, which has excellent dandruff-relieving and antipruritic properties, and can overcome any combination of compounds used alone under the same conditions. The shortcoming that the anti-dandruff effect is not obvious, produces a synergistic anti-dandruff and antipruritic effect; the composition in the form of a dispersion can also solve the problem of oil-soluble iodopropynyl compounds and water-soluble benzamidine compounds used in the same System difficulties, improve formulation compatibility and ease of use

Method used

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  • Composition and application thereof as scurf-eliminating and itch-stopping agent
  • Composition and application thereof as scurf-eliminating and itch-stopping agent
  • Composition and application thereof as scurf-eliminating and itch-stopping agent

Examples

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Effect test

Embodiment 1

[0045] Preparation of Composition Dispersion of Iodopropynyl Butylcarbamate and Dibromopropionamidine Isethionate

[0046] Add 5 grams of iodopropynyl butyl carbamate, 5 grams of dibromopropionamidine isethionate, 20.0 grams of polyoxyethylene hydrogenated castor oil, 30 grams of propylene glycol, and add water to 100 grams, and heat at 60°C Stir until completely dissolved, continue to stir, and cool to room temperature to obtain a transparent liquid, which is milky white at low temperature.

Embodiment 2

[0048] Preparation of Iodopropynyl Ethylaminobutyrate and Hexamidine Isethionate Composition Dispersion

[0049] Add 6 grams of iodopropynyl ethyl aminobutyrate, 3 grams of hexamidine isethionate, 16.0 grams of fatty alcohol polyoxyethylene ether, 30 grams of propylene glycol, and add water to 100 grams, heat at 60 ° C and stir Continue to stir until completely dissolved, and cool to room temperature to obtain a transparent liquid, which is milky white at low temperature.

Embodiment 3

[0051] Preparation of Composition Dispersion of Iodopropynyl Butylcarbamate and Octoxybenzamidine Isethionate

[0052] Add 5 grams of iodopropynyl butyl carbamate, 0.01 grams of dibromopropionamidine isethionate, 3.0 grams of polyoxyethylene hydrogenated castor oil, 85 grams of propylene glycol, and add water to 100 grams, and heat at 60°C Stir until completely dissolved, continue to stir, and cool to room temperature to obtain a transparent liquid, which is milky white at low temperature.

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Abstract

The invention discloses a composition comprising an iodopropinyl compound (I) and a benzamidine compound (II), and application of the composition as a dandruff-dispelling itch-relieving agent. The composition has excellent performances of dispelling dandruff and relieving itch, wherein the optimum weight ratio of the iodopropinyl compound (I) to the benzamidine compound (II) is between 5:95 (percent) and 95:5 (percent). The composition can form uniform dispersoid which is liquid and stable at room temperature and can be conveniently compatible with formulation so as to simplify a production process. The composition can be applied as the dandruff-dispelling itch-relieving agent to hair-use products, and has the optimum dosage of between 0.001 percent and 5 percent. The composition has good effects of inhibiting and killing pityrosporum orbiculare causing dandruff, and has synergistic dandruff dispelling effect.

Description

technical field [0001] The present invention relates to a composition and its application, in particular to a composition comprising iodopropynyl compound and benzamidine compound, and its application as an antidandruff and antipruritic agent. Background technique [0002] According to statistics, more than 80% of adults suffer from dandruff to varying degrees. Higher than normal levels of Pityrosporum fungus is one of the main causes of dandruff. There are many anti-dandruff active ingredients on the market, mainly including ketoconazole, campanol, pyridine ketone ethanolamine (OCTO) and zinc pyrithione (ZPT). The anti-dandruff mechanism of these active ingredients is mainly derived from the anti-spore fungus activity performance. Among them, ketoconazole has the best effect, but it is expensive and its application is limited. Although zinc pyrithione has a certain anti-dandruff effect, its solubility is poor and the formulation threshold is high. Although the price of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K8/40A61Q5/02A61Q5/12
Inventor 李华山薛虹宇史鲁秋
Owner 南京枫华投资管理有限公司
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