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Use of lithium salt in preparing medicine for treating addict to psychostimulant

A technology of mental excitement and drugs, applied in the direction of drug combinations, pharmaceutical formulas, inorganic active ingredients, etc., can solve the problems of no discovery, achieve good results, and improve the effect of mental dependence

Inactive Publication Date: 2009-07-29
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After searching, there is no report about improving psychostimulant drug addiction by inhibiting GSK-3β activity against lithium salt

Method used

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  • Use of lithium salt in preparing medicine for treating addict to psychostimulant
  • Use of lithium salt in preparing medicine for treating addict to psychostimulant
  • Use of lithium salt in preparing medicine for treating addict to psychostimulant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Lithium chloride inhibits the formation of cocaine sensitization test (behavioral)

[0022] Test grouping: 32 SD rats (purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.) were divided into 4 groups, as follows:

[0023] Group A: 8 rats in the normal saline + normal saline group

[0024] Group B: 8 rats in lithium chloride + saline group

[0025] Group C: 8 rats in the normal saline + cocaine group

[0026] Group D: lithium chloride + cocaine group 8

[0027] Spontaneous activity experiments were used to establish a behavioral sensitization model of cocaine in SD rats.

[0028] (1) Establishment of a model of cocaine behavioral sensitization in rats

[0029] Adaptation stage: On day 1, all 32 rats were acclimatized in a spontaneous activity box (purchased from Shanghai Jiliang Software Technology Co., Ltd.) for 2 hours, and on day 2 and 3, all 32 rats were acclimatized in the box for 2 hours after intraperitoneal injection of normal saline....

Embodiment 2

[0040]Example 2 Detection test of inhibition of GSK-3β activity in central nucleus accumbens by lithium chloride

[0041] The source of the rats in this experiment is the same batch as in Example 1, and the experiment groups are:

[0042] Group A: 8 rats in the normal saline + normal saline group

[0043] Group B: 8 rats in lithium chloride + saline group

[0044] Group C: 8 rats in the normal saline + cocaine group

[0045] Group D: lithium chloride + cocaine group 8

[0046] The operations for the first 14 days of each group A, B, C, and D were the same as the behavioral training experiment of Example 1. Then on the 15th day, all 32 rats were decapitated, and the central nucleus of the nucleus accumbens was taken out. Protein staining technology ((1) Brain tissue preparation: rat decapitation, brain tissue (nucleus accumbens) freezing (-40℃); (2) Brain tissue homogenization, centrifugation, protein quantification; (3) Protein staining Technology (Western blotting); (4) Primary a...

Embodiment 3

[0048] Example 3 Lithium chloride inhibits the expression of behavioral sensitization in rats (behavioral)

[0049] Test groups: (1) 18 rats in the saline group

[0050] (2) 21 cocaine group

[0051] The spontaneous activity experiment was used to establish a behavioral sensitized expression model of cocaine in S-D rats.

[0052] (1) Establishment of a behavioral sensitization expression model in rats

[0053] Adaptation stage: On the first day, all 39 rats were acclimatized in the spontaneous activity box for 2 hours, and on the second and third days, all rats were acclimatized in the box for 2 hours after intraperitoneal injection of normal saline.

[0054] Training phase (behavior sensitization expression phase):

[0055] The 18 rats in group (1) received daily intraperitoneal injection of saline: the concentration was 1 mg / ml, the dose was 1 mg / kg, and the spontaneous activity was tested for 2 hours for 14 consecutive days. After the normal saline injection was stopped for 5 d...

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Abstract

The invention discloses application of lithium salt in preparing a medicine for treating psychostimulant addiction and application of the lithium salt in preparing a medicine for preventing the relapse after psychostimulant detoxication. The invention provides an effective way for treating drug addiction caused by behavioral sensitization of psychostimulants (such as cocaine, and the like); moreover, the invention has good effect and can radically improve the psychological dependence of psychostimulant addicts.

Description

Technical field [0001] The invention belongs to the field of addictive drugs, and specifically relates to the application of lithium salt in the preparation of drugs for treating addiction to psychostimulant drugs. Background technique [0002] Drug addiction is a major public health and social problem that plagues global human health and social development. It severely endangers human health, affects family stability and social development, and causes huge economic losses to society. For example, among the newly infected cases of AIDS in my country in 2007, about 42% of patients were related to drug addiction and abuse. [0003] Drug addiction is a chronic and highly recurring complex brain disease. It is characterized by a progressive development from impulsive drug-seeking caused by initial drug use to compulsive drug-seeking, forming a strong physical and mental dependence. Long-term use of addictive substances can cause dysfunction and histopathological changes in the body, ...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K33/24A61P25/00
Inventor 陆林徐春梅朱维莉
Owner PEKING UNIV
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