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Method for preparing high-purity acamprosate calcium

A kind of calcium acamprosate, high-purity technology, applied in the field of preparation of high-purity calcium acamprosate, can solve problems such as not mentioned, and achieve the effect of economical production

Active Publication Date: 2014-03-12
北京华禧联合科技发展有限公司
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  • Abstract
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Problems solved by technology

In the patent US4355043 and other published reports on the preparation of calcium acamprosate, there is no mention of the use of economical and effective preparation of high-purity calcium acamprosate

Method used

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  • Method for preparing high-purity acamprosate calcium

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Embodiment 1

[0012] The preparation of embodiment 1 high-purity acamprosate calcium

[0013] Add 234.0g of calcium hydroxide and 2360ml of water into a 5L three-necked flask, stir at room temperature and add 380.0g of acetic acid, then add 885.0g of homotaurine, keep the temperature at 25~40℃, add 1.0kg of acetic anhydride, and react at 30~40℃ for 2 Hours, concentrated under reduced pressure to obtain 1240.0 g of off-white solid, yield 95.7%.

[0014] Add 1240.0 g of the crude product to 1250 ml of water to dissolve, add 2.5 L of ethanol dropwise under stirring, a large amount of solids precipitate out, filter to obtain an off-white solid, then add 700 ml of water to dissolve, add 1.4 L of ethanol dropwise under stirring, a large amount of solids precipitate out, filter, and dry. 412.0 g of off-white solid was obtained with a yield of 33.2%.

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Abstract

The invention relates to a preparation method of using mixed solvent of ethanol water to dissolve and devitrify Acamprosate calcium with low purity to obtain Acamprosate calcium with high purity.

Description

Technical field [0001] The invention relates to a preparation method of high-purity calcium acamprosate. Background technique [0002] According to existing literature reports, acamprosate calcium is mainly prepared according to the method described in the patent US4355043: [0003] [0004] Prepared according to this method, the product is a mixture of calcium homotaurate and calcium acetyl homotaurate (calcium acamprosate). Due to the very similar physical and chemical properties of this mixture, purification is very difficult. In the patent US4355043 and other published reports on the preparation of calcium acamprosate, there is no mention of the economical and effective preparation of high-purity calcium acamprosate. [0005] Based on the above reasons, it is necessary to develop a simple, effective, easy-to-operate and economical method for preparing high-purity calcium acamprosate. Contents of the invention [0006] The invention relates to a preparation method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C309/15C07C303/02
Inventor 曹志华
Owner 北京华禧联合科技发展有限公司
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